New Products

Jan 12, 2018

Castle Biosciences DecisionDx-UMSeq Panel

Castle Biosciences has launched the DecisionDx-UMSeq panel, which uses next-generation sequencing to identify somatic mutations in genes relevant to uveal melanoma. The panel will evaluate DNA mutations in seven genes known to be relevant to UM: GNAQ, GNA11, PLCB4, CYSLTR2, SF3B1, exons 1-2 of EIF1AX, and coding exons of BAP1. While no currently available therapies target pathways affected by the gene mutations evaluated in the panel, the genomic information may be useful in the future to inform patient care as UM research and therapeutic options evolve, the company noted. The assay will complement Castle's DecisionDx-UM gene expression profile test for assessing likelihood of metastasis in UM.

Jan 12, 2018

Dovetail Genomics Hi-C Kit

Dovetail Genomics has introduced the Dovetail Hi-C Kit with cloud-based HiRise software for genome assembly, its first commercial kit, enabling researchers to generate chromosome-scale assemblies in house. Dovetail also said that it has lowered the pricing of its scaffolding service, a result of efficiencies achieved by building and delivering hundreds of assemblies over the last few years.

Jan 10, 2018

Thermo Fisher Scientific Ion Torrent Oncomine Pan-Cancer Cell-Free and Tumor Mutation Load Assays

Thermo Fisher Scientific has launched two new Oncomine assays. The Ion Torrent Oncomine Pan-Cancer Cell-Free Assay is designed for the analysis of tumor DNA and RNA for all major classes of mutations. The assay, which targets more than 50 genes across multiple tumor types, including lung, colorectal, breast, pancreatic, and thyroid cancer, requires a single vial of blood and as little as 1 nanogram of nucleic acid input material and can be completed in two days. The Ion Torrent Oncomine Mutation Load Assay sequences 409 genes using as little as 20 nanograms of DNA from formalin-fixed paraffin-embedded tissue. It is designed to improve selection strategies for immunoherapy clinical trials.

Jan 04, 2018

Fluxion ERASE-Seq NGS Liquid Biopsy Analysis Service

Fluxion Biosciences said that its ERASE-Seq bioinformatics solution can now be used for variant calling from a wide range of targeted cancer panels. The analysis tool was previously limited to use on Fluxion's Spotlight 59 cancer panel. Users can now apply ERASE-Seq to Swift Biosciences' Accel Amplicon 56G panel and Illumina's TruSight Tumor 15 panel using bioinformatic analyses that are already cloud accessible. Other custom and commercial panels that customers may be interested in can also be added following validation testing by Fluxion, the company said.

Jan 03, 2018

Mobidiag Novodiag

Mobidiag launched the Novodiag, a fully automated solution for syndromic and targeted testing for infectious disease. Novodiag allows direct analysis of a patient sample in a disposable cartridge and delivers results in a few hours, according to the firm. It also allows for the detection of antibiotic resistance. The PCR and microarray-based instrument is aimed at small- to medium-sized clinical microbiology labs with lower throughput requirements. 

Jan 02, 2018

Quanterix SR-X Ultra-Sensitive Biomarker Detection System

Quanterix has announced the commercial availability of its SR-X Ultra-Sensitive Biomarker Detection system, powered by the firm's Simoa technology. The research-use-only system lets users design assays to detect both proteins and nucleic acids directly from blood, as well as several other complex sample types. The SR-X enables measurement of nucleic acid levels, including miRNA, without using PCR. The platform is designed to detect up to six biomarkers per sample, with low volume requirements, the company said.

Dec 20, 2017

Precipio ICE-COLD PCR Kit for Sanger Sequencing

Precipio has launched a second new version of its ICE-COLD PCR enrichment kit for use in Sanger Sequencing platforms. The multiplex panel allows identification of resistance mutations in the blood of patients with non-small cell lung cancer. Adaptation of the kit for Sanger sequencing is part of a larger effort by Precipio to modify its technology to be platform-agnostic, the company said. At approximately $150 per test, Precipio believes that its technology offers significant savings compared to competing assays for the same liquid biopsy application.

Dec 15, 2017

Olink Mouse Exploratory

Olink Proteomics has launched the Olink Mouse Exploratory panel to measure mouse proteins. The panel is based on the company's proximity extension assay technology, and enables simultaneous analysis of 92 protein biomarkers, consuming just 1 µL of biological sample such as serum or plasma. The proteins assayed in the panel encompass a broad range of biological functions and pathways, making this an ideal tool for exploratory studies aimed at discovering new biomarkers and protein signatures in mouse studies, the company said.

Dec 15, 2017

JN Medsys Clarity Plus+

JN Medsys has launched the next generation of its digital PCR system, featuring more than 40,000 partitions and 4- to 6- colour detection channels.
The new system offers better specifications over the firm's Clarity system, featuring improved consumables providing at least 4 times more partitions and employing ultra-high density chips that can generate more than 40,000 partitions per reaction to provide greater dynamic range and better accuracy. 
The increase in partitions is also designed around the same footprint as the original system, such that the new tube-strips still fit conventional thermal cyclers to allow up to 96 reactions per run. The new system also comes with a more powerful reader equipped with a 4- to 6-colour detection system to increase detection throughput in digital PCR. It can now detect up to 384 or 576 different targets per run.
Dec 14, 2017

Paradigm Diagnostics PCDx Tests

Paradigm Diagnostics said that all of its Paradigm Cancer Diagnostic (PCDx) tests ordered for lung cancer patients now also include 17 fusions, as well as EGFR and MET skipping events. The fusions include: ALK, AXL, BRAF, CCND1, FGFR1, FGFR2, FGFR3, MET, NGR1, NTRK1, NTRK2, NTRK3, PPARG, RAF1, RET, ROS1 and THADA. The fusion panel may also be ordered as an add-on for any PCDx patients and will be delivered within in the company's standard five-day turnaround time. The assay uses anchored PCR technology on RNA to detect known and novel fusions with high sensitivity with a tissue requirement of 4 percent or greater tumor content in a single core needle biopsy or fine needle aspirate.

Dec 14, 2017

OmniTier CompStor Assembly

OmniTier has introduced CompStor Assembly for de novo DNA assembly and reference alignment. Designed for short-read next-generation sequencing data, CompStor Assembly reduces assembly times and improves assembly quality on low-cost hardware compared to currently available assemblers, the company said. Using CompStor Assembly and eight CompStor Assembly server nodes, de novo assembly of a human genome can be achieved in about eight minutes. This performance equals the assembly time previously achieved with the NERSC's Cray XC30 advanced supercomputer, using 15,360 processor cores and DRAM-based algorithm implementations, OmniTier noted. By contrast, CompStor Assembly nodes are standard servers based on low-cost x86 Intel processors and tiered DRAM and NVMe SSDs.

Dec 14, 2017

Synthego CRISPRevolution Gene Knockout Kit

Synthego has launched its new CRISPRevolution Gene Knockout Kit (GKO) for all CRISPR researchers, including those developing emerging therapeutic modalities with increasing genome engineering demands such as CAR-T immunotherapy and treatment of monogenic diseases. The CRISPRevolution GKO includes four top-scoring guides from Synthego's CRISPR Design Tool, provided as high efficiency chemically modified synthetic sgRNAs, SpCas9 protein, and control reagents to optimize transfection protocols. This kit has an easy-to-use experimental workflow, and comes with a money-back guarantee on 50 percent or better editing in any human cell type for research use.

Dec 12, 2017

Trovagene NextCollect Kit

Trovagene has announced that its NextCollect urine collection and DNA preservation kit is now available, for research use only, to clinical research laboratories and pharmaceutical customers. The kit is a high-volume urine specimen collection and stabilization tool, and is available for both existing contracted clients and to new customers through an online web portal, the company said. 

Additionally, Trovagene said that it plans to make DNA Isolation Buffer Kits that complement NextCollect available in early 2018, using methods developed as part of the firm's Trovera ctDNA tests.

Dec 12, 2017

Biomatters' Geneious Biologics SAAS

Biomatters has released a new version of Geneious Biologics, an enterprise software-as-a-service solution for commercial antibody screening and discovery. The new release features a capability that will allow developers of biological drugs to analyze millions of raw antibody sequences in minutes, accelerating the identification of therapeutic antibody candidates. The software enables users to preview, annotate, and compare NGS sequnces with no manual intervention, the company noted.

Dec 08, 2017

Thermo Fisher Scientific Ion Torrent Oncomine Myeloid Research Assay

Thermo Fisher Scientific has introduced the Ion Torrent Oncomine Myeloid Research Assay, a targeted next-generation sequencing research panel for simultaneous analysis of 74 relevant genes. The panel is designed to interrogate DNA mutations, RNA fusion transcripts, and gene expression levels associated with myeloid cancers in a single run yielding results in two to three days. The Ion Chef System is used for library preparation, reducing total hands-on time to under 45 minutes. In addition, access to the Oncomine Knowledge Reporter will allow users to link variants to relevant labels, guidelines, and global clinical trials. The assay is also fully compatible with the Ion PGM and Ion S5 systems, Thermo Fisher said.

Dec 08, 2017

Promega Maxwell RSC PureFood Pathogen Kit

Promega's new Maxwell RSC PureFood Pathogen Kit provides food safety labs with an automated DNA purification methods for PCR-based testing of food pathogens. The kit does not require enzymatic pretreatment and, when used in combination with the Maxwell RSC Instrument, can effectively purify DNA from one to 16 food matrix samples in 40 minutes, the company said.

Dec 06, 2017

Sygnis TruePrime Apoptotic Cell-Free DNA Amplification Kit

Sygnis has launched the TruePrime apoptotic cell-free DNA amplification kit under the Expedeon brand. The kit enables accurate DNA amplification using cell-free DNA from plasma, serum, urine, cerebrospinal fluid, and other bodily fluids. The kit uses a multiple displacement amplification method to overcome common limitations of cell-free DNA analysis of such fluids, Sygnis said, adding it provides users with "excellent sensitivity, error-free amplification in hih yields, and a streamlined workflow for reduced hands-on time." 

Dec 05, 2017

Horizon Discovery EGFR Multiplex cfDNA Reference Standard

Horizon Discovery has launched a new cell line-derived EGFR Multiplex cell-free DNA reference standard, which allows labs and assay developers to optimize, validate and routinely monitor performance of PCR assays, NGS tests, and other novel liquid biopsy tests designed to detect EGFR mutations in cfDNA.

The new referene standard covers ten of the most clinically relevant mutations that predict responsiveness to EGFR tyrosine kinase inhibitors, including T790M, L858R, C797S and E746-A750del. Additionally, variants have been carefully selected to represent a mix of different mutation types that can be challenging for laboratories to detect.

Dec 05, 2017

Thermo Fisher Scientific RapidFinder Salmonella Multiplex System

Thermo Fisher Scientific has launched its RapidFinder Salmonella Multiplex PCR Detection Workflow for simultaneous and multiplexed detection of Salmonella typhimurum and Salmonella enteriditis. The real-time PCR workflow features easy sample preparation and results in as few as 16 hours from raw and cooked poultry and pork, in addition to production environment samples. Thermo's workflow offers simple sample enrichment and PCR preparation protocols, as well as TaqMan-based PCR probe technology for improved sensitivity, specificity, and reliability. The workflow runs on the Applied Biosystems Food Safety 7500 Fast System and Food Safety QuantStudio 5 System. In addition, the workflow has received AOAC-RI PTM certificaton as part of an extensive validation progrma to address salmonella testing needs at all stages of the poultry and pork production process.   

Dec 04, 2017

Google AI DeepVariant

Google AI has released DeepVariant, a deep-learning technology for improving the accuracy of genome sequencing, as an open-source product. Google said that this version is more accurate than the the original version of DeepVariant, which won a PrecisionFDA Truth Challenge award for highest SNP accuracy. This release also helps outside researchers identify gene variants.

Dec 01, 2017

Cyclica Ligand Express

Toronto-based company Cyclica has launched a cloud-based proteome screening platform called Ligand Express. The platform provides users access to the company's AI-assisted, structure-based molecular simulation technology. Users can submit small molecules of interest to rapidly generate unique polypharmacology profiles. These profiles consist of on- and off-target interactions that may be expected, as well as those that are unanticipated, to aid decision making. Off-target interactions can be viewed using the platform's interactive, analytical tools that enable exploration and facilitate deep insights that cannot be gained through traditional target-based approaches.

Dec 01, 2017

OncoDNA's OncoSelect

Belgian biotech firm OncoDNA has launched OncoSelect, an assay for circulating tumor DNA in blood samples from non-small cell lung cancer, colon cancer, or breast cancer (ER+ or HER2+) patients. OncoSelect assays for more than 100 mutatioons of resistance and sensitivity to targeted therapies. To monitor progression of cancer, the test should ideally be performed midway through treatment and two weeks after the last does, the company said. Turnaround time from receipt of sample to issuance of a full report to the treating oncologist is seven working days.

Nov 30, 2017

Horizon Discovery 5-Fusion Multiplex FFPE RNA Reference Standard

The 5-Fusion Multiplex FFPE RNA Reference Standard from Horizon Discovery is a highly characterized, biologically relevant quality control material used to assess the performance of targeted NGS, RT-PCR, and RT-qPCR assays for gene fusions. Each FFPE curl is composed of a formalin-fixed, paraffin-embedded cell line verified to contain EML4-ALK, CCDC6-RET, SLC34A2-ROS1, TPM3-NTRK1, and ETV6-NTRK3 fusions. Using the reference standard it is possible to evaluate workflow integrity from pre-analytical RNA extraction to fusion detection. Extractable RNA is at least 100 ng, the company noted.

Nov 30, 2017

Avacta Anti di-Ubiquitin K6 and K33 Affimers

Avacta has released Anti di-Ubiquitin K6 and K33 Affimers. Affimer binders are produced entirely in vitro and are therefore not restricted by the host immune system. The technology is suited for difficult targets such as K6 and K33, the exact function of which is largely unknown due to the limited tools available. The Anti di-Ubiquitin Affimer range is human-specific and includes a variety of tagged binders displaying high affinities for poly-ubiquitin chains formed by K6 or K33 linkages, in protein expression studies.

Nov 30, 2017

Edico Dragen Complete Suite

Edico Genome has introduced Dragen Complete Suite on AWS Marketplace, providing Amazon Web Services users with one-click access to all Dragen next-generation sequencing data analysis applications. The Dragen CS package includes version 2 of both the germline and somatic pipelines. Dragen CS contains tools for all pipeline steps, including mapping/aligning, position sorting, duplicate marking, and variant calling. The application accepts sequencing data inputs in BCL, FASTQ, and BAM/CRAM formats, and features BCL conversion, download and upload streaming, and compressed hash tables for a more streamlined and efficient workflow.


Magdalena Skipper, the incoming editor-in-chief of Nature, speaks with NPR's Weekend Edition Sunday.

Genetic genealogy has led to an arrest in another cold case, dating back to 1987.

In PLOS this week: mutation in second gene widens clinical symptoms of people with ADD3 mutations, comparative genomic analysis of Pseudovibrio, and more.

Wired reports that 23andMe is trying to bolster its outside collaborations.