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Sep 17, 2019

Biognosys Spectronaut 13.7

Biognosys of Switzerland has released a new version of its Spectronaut 13 mass spectrometry analysis software. The update, version 13.7, includes beta support for the parallel accumulation-serial fragmentation (PASEF) and diaPASEF methods, which are available on Bruker's timsTOF Pro instrument.

Sep 12, 2019

Euformatics OmnomicsQ Ion Torrent Suite Plugin

Euformatics has launched the OmnomicsQ Ion Torrent Suite plugin. The software can be fully integrated with Thermo Fisher Scientific Ion Torrent sequencers to enable users to access quality control metrics and graphics as part of their workflows without the need for manual external program integration. The plugin gives Ion Torrent Suite users quality information for every sample run as part of their standard run procedure, helping to eliminate errors and flagging any issues with data quality before it affects patients, Helsinki-based Euformatics noted. In addition, the plugin enables users to perform clinical test validation of their next-generation sequencing pipelines with the OmnomicsV validation and verification software.

Sep 09, 2019

Sphere Fluidics Cyto-Cellect Human IgGk Detection Kit

Sphere Fluidics has launched its Cyto-Cellect Human IgGk Detection Kit to measure antibody class and productivity for cell line development. The FRET-based assay detects the presence of human IgG from encapsulated cells in picodroplets with kappa light chain after secretion, characterizing and measuring antibody production. According to the firm, users can combine the kit with with the Cyto-Mine Single Cell Analysis System.  

Sep 09, 2019

Fluidigm Advanta RNA-Seq NGS Library Prep Kit

Fluidigm has launched its Advanta RNA-Seq NGS Library Prep Kit, which runs on the firm's Juno microfluidic system. According to the firm, the next-generation sequencing kit allows researchers to reduce their costs for full-length stranded libraries by up to 50 percent. Fluidigm noted that the automated workflow can also reduce the number of operator interventions and total hands-on time to about two hours. The kit allows researchers to simultaneously process up to 48 samples using a integrated microfluidic circuit (IFC). By integrating solid-phase sample enrichment with sequential enzymatic reaction on the IFC, the workflow automates multiple reaction steps to product up to 48 libraries for sequencing on Illumina systems. 

Sep 06, 2019

Fluidigm Maxpar Imaging Mass Cytometry Kits; CyTOF Software

Fluidigm this week launched three new imaging mass cytometry kits and new CyTOF software at the 2019 World Molecular Imaging Congress.

Fluidigm's Maxpar Human Immuno-Oncology Panel Kits are designed for immune-oncology research. Developed using pathologist-verified antibodies, the panels can be mixed and matched to profile tumor-infiltrating lymphocytes, immune cell activation states, and tissue architecture. By combining them as a single 18-marker panel, researchers can broadly profile activated tumor-infiltrating lymphocytes for single-cell analysis of tumor architecture from a single tissue scan, Fluidigm said.

Fluidigm's CyTOF software, meantime, is designed to be used with the Hyperion Imaging System for cellular biomarker identification. According to the firm, the software streamlines the selection and acquisition of multiple regions of interest (ROI) from each slide. Researchers can remotely annotate those ROIs using brightfield reference images to guide automated batch acquisition of highly multiplexed images at 1-micron resolution. During image acquisition, researchers can visualize multiplexed images in real time across all detection channels to ensure data quality, Fluidigm said.

Sep 05, 2019

Swift Biosciences RNA Library Kits

Swift Biosciences has launched its RNA Library Kits. With patented Adaptase technology, the kits allow direct conversion of first-strand complementary DNA, reverse transcribed from RNA, into libraries for Illumina sequencing.

The firm is offering two kits: the Swift RNA Library Kit, which supports a broad input range from as little as 10 nanograms of total RNA or 100 picograms of poly(A)-enriched messenger RNA or ribosomal RNA-depleted RNA, and the Swift Rapid RNA Library Kit, which is faster and lower-priced. Both kits are available in 24- or 96-reaction kits.

The products include an RNA fragmentation module, a reverse transcription module, library prep reagents, polymerase, and several indexing primer kit options for single, combinatorial, and unique dual indexing.

Sep 04, 2019

Xifin LIS 6

Xifin has introduced a new version of its laboratory information system, Xifin LIS 6. The latest iteration of the software-as-a-service platform includes several features resulting from recently formed partnerships. Notably, Xifin LIS 6 includes artificial intellegence-driven genomic data interpretation, thanks to a partnership with Fabric Genomics. The new release supports fast, scaleable analysis of next-generation sequencing to produce "physician-ready" clinical reports, the company said.  

Other upgrades in LIS 6 include support for digital pathology workflows via a collaboration with Proscia, integration of Glidian's automated prior authorization technology, and access to test utilization support from the Medical Database LDS laborator decsion system.

Aug 16, 2019

Integrated DNA Technologies oPools Oligo Pools

Integrated DNA Technologies has launched its oPools Oligo Pools, ready-to-use pools of high-quality DNA oligonucleotides. According to the Coralville, Iowa-based firm, the pools contain customized, single-stranded DNA sequences between 40 and 350 nucleotides in length. Because the pools are delivered in picomoles, researchers do not need to perform any pre-amplification or other pre-work before using the pool. IDT said that oPools' low error rate of less than 1 in 2,000 nucleotides, coupled with high per-oligo yields, allow researchers to immediately proceed into their downstream workflows including CRIPSR library construction, protein screening, and gene assembly.   

Aug 15, 2019

Loop Genomics LoopSeq Bacterial Genome Sequencing Kit and Services

Loop Genomics has launched a new sample preparation kit and service for de novo bacterial genome assembly using synthetic long reads on Illumina sequencers.

The LoopSeq Bacterial Genome Sequencing kit leverages the firm's chemistry and computational pipeline to create reads thousands of base pairs long, providing high-quality assemblies with fewer total contigs, higher N50 values, and fewer misassemblies.

San Jose, California-based Loop Genomics said the kit is plug-and-play and can easily replace existing sample preparation kits for bacterial genome sequencing experiments, using Loop's software for data analysis.

Aug 13, 2019

Dovetail Genomics Omni-C Assay

Dovetail Genomics has launched the Omni-C, a new assay based on the Hi-C method for chromosome conformation capture.

Scotts Valley, California-based Dovetail said it designed the assay for ease of use and improved reproducibility. The firm claims the assay offers better coverage compared to standard Hi-C approaches, by using an endonuclease, rather than restriction enzymes, to digest cross-linked chromatin.

Traditional restriction enzyme-based Hi-C approaches generate data only near the restriction enzyme sites, resulting in gaps of information. By using an endonuclease, Omni-C enables coverage of a significant portion of the genome that does not contain these restriction sites, estimated to be around 20 percent in human genomes. 

Applications for Omni-C include structural genetic variant detection and generating genome assemblies. 

Aug 09, 2019

Streck ARM-D Kits; RNA Complete BCT

Streck this week launched three new real-time PCR antibiotic resistance kits for research use only. The kits cover MCR, expanded OXA, and TEM/SHV/GES to detect variants of resistance genes considered by the US Centers for Disease Control.

Streck also introduced RNA Complete BCT, a direct-draw whole-blood collection tube containing a specially designed reagent which maintains the draw-time concentration of extracellular vesicles such as exosomes for up to 7 days at room temperature storage.

Aug 08, 2019

Novogene NovoPM 2.0 Cancer Panel

Chula Vista, California-based Novogene has launched its NovoPM 2.0 Cancer Panel, a next-generation sequencing panel that analyzes 484 solid tumor-related genes and introns in 43 genes. According to the firm, the test can detect four types of genomic abnormalities (single nucleotide variation, insertions/deletions, copy number variation, and fusions), and features bioinformatics software including three algorithms specific for guiding cancer immunotherapy decision making.

Aug 08, 2019

ChunLab TrueBac ID

Korean bioinformatics firm ChunLab has launched TrueBac ID, a cloud-based platform that combines proprietary algorithms and a manually curated reference database for bacterial identification targeting more than 12,000 species. The system can provide a full identification report within 30 minutes after a user uploads a genome assembly or raw shotgun sequencing data as a FASTQ file. The report provides fully resolved taxonomic classification, antimicrobial resistance genes, and virulence genes to facilitate correct diagnosis and appropriate therapy. In a recently published study, TrueBac ID was able to accurately identify 34 of 36 clinical isolates (94.4 percent) that were not identified using three commercially available MALDI-TOF MS systems. ChunLab said that it is providing the service for free to all users until the end of 2019 with certain restrictions. In 2020, the company plans to add functions such as strain typing to the platform.

Aug 02, 2019

Twist Bioscience Long Oligonucleotides

San Francisco-based Twist Bioscience has launched its long oligonucleotides product line. According to the firm, the synthetic nucleotides can be upto 300 bases and will increase the success and productivity of biological research. While adding bases normally introduces the risk of error, Twist said it has developed a proprietary way to make oligos with an error rate as low as 1:1500 nucleotides.

Jul 31, 2019

Mesa Biotech RSV

San Diego, California-based molecular diagnostics developer Mesa Biotech has launched a respiratory syncytial virus test on its sample-to-answer point-of-care PCR system, the Acula. The RSV test is the second test on the system, which also runs an influenza A/B test and is exclusively marketed in the US by Sekisui under the Silaris brand. It was cleared by the US Food and Drug Administration and CLIA-waived last year for diagnostic use in both children and adults.

Jul 29, 2019

GridIon Mk1

Oxford Nanopore Technologies has launched GridIon Mk1, an upgrade to the GridIon X5 sequencing platform that will start shipping this week. It contains more powerful GPU technology, specifically a Nvidia Volta GV100 card, so basecalling now only requires 10 percent of the GPU resource. In addition, power requirements have been simplified, which increases the stability of the platform.

Jul 23, 2019

BioDot Rainmaker

Irvine, California-based BioDot has launched its Rainmaker picoliter volume printing platform. According to the liquid handling company, Rainmaker allows researchers to use up to 24 independent tips to dispense volumes ranging from 20 pL to several nLs at high speed. BioDot said the tool's programmable drop size and precision controls allow users to shrink assays to improve performance and reduce costs, while optimizing for rheology or surface characteristics. 

Jul 22, 2019

Clear Labs Clear Safety Listeria, Environmental Mapping Testing

Menlo Park, California-based Clear Labs has launched new Listeria testing and environmental mapping capabilities on its Clear Safety next generation sequencing platform.

According to Clear Labs, Clear Safety now catalogs the genetic "fingerprint" of a Listeria sample and compares it to the fingerprints of Listeria previously encountered within a company. The platform can now detect, speciate, and characterize up to seven Listeria species ( monocytogenes, grayi, innocua, ivanovii marthii, seeligeri, and welshimeri) in a single analysis.

Clear Labs also noted that researchers can use the platform's similarity analysis to distinguish resident from transient subtypes of Listeria in the food manufacturing environment, which groups samples containing Listeria with matching fingerprints and tags them with metadata including location, date, and time. The firm's environmental mapping tool then overlays Listeria contamination on a facility map, allowing the team to track the flow of particular subtypes of Listeria through a facility over time. 

Jul 18, 2019

Menarini Silicon Biosystems VRNxT Volume Reduction Tool

Italy-based Menarini Silicon Biosystems has launched its new VRNxT automated volume reduction instrument, which removes manual sample reduction steps in cellular biology workflows. The sample prep firm said that the instrument reduces pipetting steps by using rotational motion to reduce hands-on time up to 90 percent and eliminate operator variability. The system can simultaneously process up to four samples and reduces sample volume to about 12.5 μL in 25 seconds and approximately 2 μL in about eight seconds. Menarini claims the tool will add precision and accuracy to rare-cell and single-cell analysis, minimizing the loss of samples and increasing workflow throughput. While the system has been developed to standardize Menarini's DEPArray's workflow, the firm said that researchers can use the tool for broader applications in volume reduction.

Jul 17, 2019

3M STEC Tests

3M has introduced two genetic assays for food safety testing that detect Shiga toxin-producing E. coli. The assays are compatible with the St. Paul, Minnesota-based firm's loop-mediated isothermal amplification (LAMP) instrument, the 3M Molecular Detection System.

The 3M Molecular Detection Assay 2 - STEC Gene Screen (stx and eae) detects the genes for Shiga toxin types 1 and 2, in addition to the intimin gene that allows the bacteria to attach to intestinal cells. The firm's 3M Molecular Detection Assay 2 - STEC Gene Screen (stx) specifically detects Shiga toxin genes.

Jul 15, 2019

NanoString Alzheimer’s Disease Research Panels

Seattle-based NanoString Technologies has developed a set of new nCounter gene expression panels for use in Alzheimer's disease research, which it created and tested in collaboration with the MODEL-AD consortium. The two panels — one for use in mouse studies and another for human studies — measure the expression of 770 genes covering 30 modules discovered in a recent study of human brain tissue. The firm noted that both panels are available for purchase through its website.

Jul 12, 2019

HTG Molecular EdgeSeq Data Analytics Software Version 1.2

HTG Molecular Diagnostics has released an updated version of its HTG EdgeSeq Reveal data analytics software. According to the firm, the software allows customers to streamline sample analysis processed on the HTG EdgeSeq platform. The version 1.2 update contains improved functionality, offering data analysis from the firm's HTG EdgeSeq Precision Immuno-Oncology Panel, the HTG EdgeSeq Oncology Biomarker Panel, and the HTG EdgeSeq Mouse mRNA Tumor Response Panel.

Jul 11, 2019

Co-Diagnostics Vector Smart NAM Test

Co-Diagnostics has launched its Vector Smart NAM test, which the firm said can be used to identify the presence of West Nile virus, St. Louis encephalitis, and western equine encephalitis in mosquito populations. According to Co-Diagnostics, the assay uses multiplex PCR to help centers identify locations of the diseases. 

Jul 11, 2019

Circulomics Short Read Eliminator XS, XL

Circulomics has launched two new versions of its Short Read Eliminator kit for the depletion of short DNA fragments from high molecular weight DNA samples. The Short Read Eliminator XS kit depletes DNA up to 10 kb in size and the Short Read Eliminator XL kit DNA up to 40 kb. While Circulomics designed the kits for use with its Nanobind DNA extraction kits, researchers can also use them with other DNA extraction methods.

Jul 11, 2019

Bio-Techne RNAscope HiPlex Assay

Bio-Techne released its multiplex in situ hybridization RNAscope HiPlex Assay for tissues. It enables researchers to gain insights into cellular mechanisms and functions by combining a simplistic workflow with the capability of simultaneously detecting up to twelve RNA targets, the firm said.

The research-use-only assay is an expansion of the Advanced Cell Diagnostics RNAscope platform, an advanced in situ hybridization system that enables visualization of single-molecule gene expression with single-cell resolution directly in intact tissues.

Pages

GenomeWeb reports that Veritas Genetics is suspending its US operations.

A Brazilian-led team of researchers reports it has generated a sugarcane genome assembly that encompasses more than 99 percent of its genome.

Certain plasma proteins could be used to gauge a person's age and whether they are aging well, according to HealthDay News.

In Science this week: approach to measure microRNA targeting efficiency, strategy to conduct high-throughput chemical screens at single-cell resolution, and more.