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Mar 07, 2019

BioIVT Xpressway Profile Safety Package

BioIVT has launched the Xpressway Profile Safety Package, a compendium of 46 expression profiles for genes known to play pivotal roles in drug safety assessments. These genes are included in the initial screening panel used by pharmaceutical companies to evaluate new chemical entities for potential off-target interactions and toxic effects. Once these entities have been screened against the 46 target genes, the Xpressway Profile Safety Package allows the resulting binding data to be compared with the corresponding human target expression profiles and interpreted further to assess potential safety risk, the company said. When NCEs bind to the targets, the tissue distribution of those targets can inform decision making about the compounds and chemical series. BioIVT said that it employed a rigorous, highly controlled qRT-PCR method to develop the Xpressway Profile Safety Package's gene expression data.

Mar 06, 2019

IDT rhAmpSeq Targeted Sequencing System

Integrated DNA Technologies (IDT) has launched the rhAmpSeq targeted sequencing system. The proprietary rhAmpSeq chemistry enables highly multiplexed target amplification for sequencing on Illumina platforms with high on-target rates and uniform coverage. Its applications include human disease research, sample tracking and analysis, CRISPR genome editing analysis, and agricultural biotechnology. The system makes use of IDT's RNase H2 PCR technology, employing an RNase H2/DNA polymerase enzyme system coupled with RNA-DNA hybrid primers. It has been optimized for panel sizes from tens to thousands of amplicons in a single reaction.

Mar 06, 2019

Beckman Coulter Apostle Minimax High Efficiency Cell-Free DNA Isolation Kit

Beckman Coulter has launched the Apostle MiniMax High Efficiency Cell-Free DNA Isolation Kit through an exclusive partnership with liquid biopsy firm Apostle. The tool is a magnetic nanoparticle-based kit that extracts cfDNA from plasma using manual or automated workflows. According to the firm, the kit performs reliably across a range of volume inputs while consistently recovering high quantities of cfDNA and effectively removing contaminants. 

Mar 05, 2019

Loop Genomics mRNA Transcript Counting and Phasing

Loop Genomics has launched a kit and service for mRNA transcript counting and phasing using its synthetic long-read technology that works in conjunction with next-generation sequencing on Illumina instruments. The kit costs $70 per sample and the service $299 per sample. The San Jose, California-based startup, uses unique molecular identifiers and enzymes to attach the same barcode at multiple positions along one long molecule.

Mar 01, 2019

Twist Bioscience Target Enrichment Products

Twist Bioscience has launched several new products for its Twist Human Core Exome Kit and Twist Custom Panels NGS target enrichment workflows. The products include Twist Fast Hybridization and Wash Kit, Twist Universal Blockers that allow flexible blocking and improved on-target capture, the Twist Universal Adapter System that maximizes performance for library preparation, and the Twist Mechanical Fragmentation Library Prep Kit for highly-degraded samples. According to the firm, the products will accelerate hybridization to about 15 minutes and will seamlessly integrate into any automation workflow.

Mar 01, 2019

Lexogen Corall Whole Transcriptome Library Kit

Lexogen has launched its Corall Total RNA-Seq Library Prep Kit. The firm said that researchers can use the kit for all whole-transcriptome analysis applications, including differential expression, isoform quantification, and single nucleotide polymorphism and mutation detection. Lexogen highlighted that Corall can use as little as 1 nanogram and up to 1 microgram of total RNA. The kit integrates unique molecular identifiers that facilitate the identification and removal of PCR duplicates, while ensuring high strand specificity. The kits include up to 96 i7 indices for sample multiplexing. Researchers can also add i5 indices for a total of 9,216 indexing combinations. The firm offers the kits in in 24 and 96 prep sizes, as a standalone library preparation kit, or in combination with with the RiboCop rRNA Depletion Kit.

Mar 01, 2019

Furukawa Electric Single Cell Hunter

Furukawa Electric has launched the Single Cell Hunter, a microchip-based automated live cell high-throughput screening system. Single Cell Hunter analyzes live cells on a microchip within a temperature-adjustable chamber to catch the responses of stimulated cells under near-physiological conditions and identify them in a time-lapse mode, which enables accurate evaluation of the real potential of each cell. The system features standard, pre-coated microchips for dynamic identification and recovery of fluorescence-labeled cells, or for fluorescence-linked immunosorbent assays for the identification of the cells that have an ability to secrete antibodies or specific antigen proteins. The platform also features multi-color screening, and AI-based high-precision cell-friendly pick-up and drop-off technology, which enables recovery of even a single yeast cell as small as 3 μm in diameter from a 10-μm microwell.

Mar 01, 2019

Bionano Genomics Saphyr Chip, Sample Prep, Data Analysis

Bionano Genomics this week released new products related to its Saphyr platform for structural variation detection in genome analysis. First, the company launched a new version of the Saphyr Chip with three independent flowcells. When running on the two-chip Saphyr platform models that ship in 2019, the 3 X 1300 Saphyr Chip allows customers to map up to 42 whole human genomes per week or collect 1,300 Gbp (400x) coverage in less than 48 hours for samples in each of three flowcells.

The company also released a new kit for DNA isolation from blood and cells called Bionano Prep SP (solution phase). According to the company this kit dramatically reduces the time and effort needed to obtain extremely long, ultra-high molecular weight DNA by eliminating steps like plug-lysis and drop dialysis. Bionano Prep SP enables users to manually process up to six patient samples in less than three hours or up to 12 patient samples per day, which reflects a savings of a full day from the workflow compared to the current plug-lysis approach, Bionano said. The new kit also costs less on a per-sample basis, the protocol is automatable, and the high purity of resulting DNA enables faster run times on the instrument and higher data quality, the company noted.

Bionano also announced the upcoming release of the latest version of Bionano Solve, its suite of data-analysis tools, which for the first time will be available in a cloud-based implementation called Bionano Compute On-Demand. The pipeline analyzes single molecules for structural variation detection at low-allele fractions, and is particularly suited for analysis of complex, heterogeneous cancer samples and samples with germline mosaicism, the company said. All major types of structural variation can be detected with more than 80 percent sensitivity when present in just 5 percent allele fraction, while translocations and inversions can be detected with more than 90 percent sensitivity at this low frequency.

Feb 28, 2019

Agilent Magnis NGS Prep System

Agilent has launched the Magnis NGS Prep System, a fully automated next-generation sequencing library preparation system. The firm has designed the platform to help researchers easily assay multiple genes and complex genetic aberrations from genomic DNA, including degraded samples such as formalin-fixed, paraffin-embedded specimens, Agilent said. The system comes with pre-aliquoted reagents and pre-set protocols, and is fully compatible with Agilent's SureSelect [XT HS] library prep workflow. The system can provide reproducible results with a one-day turnaround time, Agilent noted.

Feb 27, 2019

Dolomite Bio scRNA-Seq Reagent Kit

Dolomite Bio has launched its new scRNA-Seq Reagent Kit, which the firm said will expand the Nadia instrument portfolio. Dolomite said it has designed the kit to allow reliable and robust generation of PCR-amplified cDNA libraries on its Nadia instrument, allowing researchers to achieve reproducible datasets at low sequencing costs. The firm said that the set up also allows users to adjust the number of single cell cDNA libraries prior to sequencing, which it believes will ensure cost-efficient single cell analysis.

Feb 22, 2019

Stratec Molecular InviMag FFPE DNA Kit

Stratec Molecular has launched its InviMag FFPE DNA kit, which the firm said allows efficient, fully automated purification of pure and PCR inhibitor-free DNA from formalin-fixed, paraffin-embedded tissue samples on its InviGenius PLUS platform. The instrument uses a robotic system for a magnetic bead-based isolation of nucleic acids from 12 samples in parallel. Stratec said the method reduces hands-on time, with only 15 minutes of preparation time for loading the instrument and protocol selection. The firm believes the kit will help increase productivity and efficiency to obtain reliable test results in molecular pathology analysis.

Feb 19, 2019

Clear Labs Clear Safety NGS Platform

Clear Labs has released a software update for its Clear Safety NGS platform, which now includes Salmonella serotyping. According to the firm, food safety professionals can now detect up to 40 unique Salmonella serotypes in an enriched sample in about 24 hours. With the update, Clear Labs said that the platform allows food manufacturers and service labs to test for the presence or absence of pathogens and serotypes at the same time. In addition, the firm noted that customers can now choose if they want to test for the disease at the genus level, species level, or the serotype level. 

Feb 12, 2019

Arrow Diagnostics ArrowforNGS Microbiota Solution A/B

Arrow Diagnostics has launched two library preparation kits for bacterial 16S rRNA gene sequencing, called ArrowforNGS Microbiota Solution A/B. The kits come with dedicated analysis software. Microbiota Solution A amplifies 16S hypervariable regions V1-V2-V3 and Microbiota Solution B amplifies 16S hypervariable regions V3-V4-V6. Both kits are compatible with the Illumina MiSeq sequencing platform.

Feb 12, 2019

Varigen Biosciences Biosynthetic Gene Cluster Custom Cloning Service

Varigen Biosciences has launched custom cloning of bacterial or fungal biosynthetic gene clusters of up to 100 kb in length. The company said that its DNAtrap technology enables it to deliver intact gene cluster clones from microbes in 10 days. Varigen has cloned 32 PKS, NRPS, and other pathways of interest with high fidelity from dozens of bacterial and fungal strains. In addition, for already-cloned pathways the firm offers shuttling to its new heterologous BGC expression vector.

Feb 12, 2019

Bode Technology Forensic Genealogy Service

Bode Technology has launched a new forensic genealogy service to law enforcement investigators and crime laboratories. The service provides forensic accredited DNA services for sample handling, extraction, and confirmation testing. The tool integrates advanced DNA testing and genealogy to develop ancestral relationships between the samples and deliver leads to the firm's clients. By using its forensic laboratory, clinical testing laboratory, and experienced genealogists, Bode said it has developed a high-quality, turn-key solution for clients from sample submission through confirmation testing. 

Feb 12, 2019

Promega Maxwell RSC miRNA Plasma, Serum Kit

Promega has launched its Maxwell RSC miRNA Plasma and Serum kit. The firm said that the kit offers oncology and translational researchers a simple and automated protocol to purify circulating RNA — including miRNA — from plasma, serum, and enriched exosomes for techniques such as next-generation sequencing or droplet digital PCR. Researchers can use the kit with Promega's Maxwell RSC and RSC 48 instruments, which the firm said will reduce hands-on time for researchers and provide consistent, high-quality, and amplifiable miRNA. 

Feb 12, 2019

Myriad Genetics Prequel

Myriad Genetics commercially launched an enhanced version of the Prequel Prenatal Screen. The enhanced noninvasive prenatal screen analyzes 23 chromosome pairs instead of the standard five chromosomes (13, 18, 21, X and Y) it previously gauged. According to the company, the ability to assess additional chromosomes enhances the test's clinical utility by improving aneuploidy detection by 30 percent. Myriad is combining the NIPS Prequel tests with its Foresight Carrier Screen and is marketing them to all female patients, including women who have a high body mass index, are an ovum donor, or have a twin pregnancy. The expanded offering will be available for doctors to order on Feb. 19. 

Feb 12, 2019

Invitae NIPS

Invitae has added non-invasive prenatal screening (NIPS) to its offerings and integrated it as part of the firm's carrier screening test. The NIPS test analyzes cell-free DNA to assess whether a pregnancy is at heightened risk for three common chromosomal disorders, including trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). There is no additional charge for adding microdeletion and sex chromosome analysis. The carrier screen sequences 301 genes linked to serious genetic disorders, and now the same specimen collection kit will also enable NIPS. Invitae will begin accepting NIPS test orders next week.

Feb 08, 2019

MGI Automated Sample Prep Workstations

MGI, a subsidiary of BGI, has introduced its MGISP series of automated sample preparation workstations worldwide. The portfolio includes the MGISP-960, a workstation with options for built-in thermocycler for PCR, isotherm stage, shaker, magnetic racks, and on-deck functions that prepare up to 96 samples simultaneously. According to the firm, the tool covers several applications, including genomics, cell biology, drug discovery, and protein science. In addition, MGI has introduced the MGISP-100, a 16 sample automated workstation that it said is optimized for NGS applications. 

Feb 07, 2019

ArcticZymes T4 DNA Ligase

ArcticZymes, a Biotec Pharmacon subsidiary, has released a T4 DNA ligase, its first commercial ligase enzyme. T4 DNA ligase is the most widely used enzyme in the ligase family, and works by joining DNA fragments together. It is used in the development of kits and products for in vitro diagnostics and molecular research. The ligase is produced under strict ISO 13485 guidelines, and can be used by customers either in combination with their own enzymes or alongside other ArcticZymes enzymes.

Feb 06, 2019

Illumina NovaSeq 6000 S Prime Reagent Kits

Illumina has launched its S Prime Reagent Kits for the NovaSeq 6000 next-generation sequencing instrument. The kits, which are available in 100-, 300-, and 500-Cycle configurations, enable paired-end reads as long as 250 bases. They require run times of 13 hours for 50-base paired end reads and up to 38 hours for 250-base paired end reads. Illumina said that total throughput is between 65 and 400 gigabases, depending on the read length.

Feb 06, 2019

OncoDNA NTRK Gene Fusion Assay

OncoDNA has released its OncoNTRK assay for solid or liquid biopsies analysis of tumors with potential NTRK gene fusions. According to the firm, the assay is the first commercial kit available for NTRK 1, 2, and 3 gene fusion profiling based on RNA-sequencing. OncoDNA said that the assay is particulary interesting for use in non-small cell lung cancer, pediatric glioblastoma, and thyroid cancer.

Feb 05, 2019

Baylor Genetics Clinical Whole-Genome Sequencing for Genetic Disorders

Baylor Genetics has launched clinical whole-genome sequencing for the diagnosis of rare genetic and inherited disorders. The test covers various mutation types throughout the genome, including single-nucleotide variants, indels, copy number variants, structural variants, regions of absence of heterozygosity, and repeat expansion variants. It requires a sample from patient and parents and has a turnaround time of 8 to 10 weeks.

Feb 05, 2019

Caris Life Sciences MI Transcriptome

Caris Life Sciences has launched a whole-transcriptome assay, MI Transcriptome, to sequence the transcriptome of patients' tumors. The assay generates on average 60 million reads per patient to enable detection of fusions, splice variants, and gene expression. The company plans to submit the assay to the US Food and Drug Administration for pre-market approval review in the first half of the year.

Feb 05, 2019

Tecan NGS DreamPrep

Tecan has launched NGS DreamPrep, an automated next-generation sequencing library prep instrument. NGS DreamPrep combines Tecan's Fluent liquid handler, Infinite plate reader, and Celero DNA-Seq and Universal Plus mRNA-Seq library prep kits.

Pages

New US Department of Commerce rules will affect supercomputing in China, according to the Wall Street Journal.

A new analysis finds that it will be more than a century until female computer scientists publish at the same rate as their male counterparts, ScienceInsider reports.

Broad Institute researchers describe an approach they've dubbed "DNA microscopy."

In PLOS this week: epigenetic changes following hepatitis C virus treatment, metagenomic analysis of Ugandan children with febrile illness, and more.