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Feb 19, 2020

Covaris Viral RNA Extraction Kits

Covaris has launched two new kits for viral RNA extraction from nasal or throat swab sample collection devices. The truXTRAC Viral RNA Extraction kit uses Puritan swabs and contains all components for the firm's adaptive focused acoustics-based extraction as well as magnetic bead-based purification of high-quality RNA from synthetic swabs. The truXTRAC-PCR Direct Viral RNA Extraction kit can be used directly in real time RT-PCR assays without prior purification, provided an internal control is included.

Feb 19, 2020

Integrated DNA Technologies xGen Prism DNA Library Prep Kit

Integrated DNA Technologies (IDT), a Danaher company, has launched the xGen Prism DNA Library Prep Kit, which is designed for challenging and low-quality samples. The kit can convert cell-free DNA and DNA from formalin-fixed paraffin-embedded tissue into high-quality next-gen sequencing libraries. It greatly reduces adapter dimers and uses unique molecular identifiers (UMIs) for enhanced error correction.

Feb 18, 2020

Thermo Fisher Scientific Applied Biosystems PowerTrack SYBR Green PCR Master Mix

Thermo Fisher Scientific has released the Applied Biosystems PowerTrack SYBR Green PCR Master Mix. It is designed for real-time PCR workflows and is compatible with all qPCR instruments. It contains a two-color tracking dye system to help researchers keep track of where they have pipetted. The mix uses an antibody-mediated hot-start mechanism to control activation of the Taq enzyme. It also includes UNG and dUTP enzymes to prevents previously amplified PCR products from contaminating subsequent qPCR reactions. The mix provides results ranging from 0.1 pg to 100 ng of complementary DNA per reaction and can be used in standard or fast cycling mode.

Feb 18, 2020

Nebula Genomics 30X Whole-Genome Sequencing Service

Nebula Genomics has launched a new, direct-to-consumer whole-genome sequencing service. Performed with MGI DNBSEQ T-Series instruments in BGI's global network of sequencing centers, Nebula's service offers 30X coverage for $299.

Individuals who sequence their genome through Nebula will retain full control of their genomic data, the firm added in a statement.

Feb 13, 2020

PerkinElmer Sciclone G3 NGSx HT Workstation

PerkinElmer has launched the Sciclone G3 NGSx HT Workstation for automated next-generation sequencing library preparation. The instrument comes with a 384-plex low-volume pipetting head, on-deck thermal elements, a shaker, a thermal cycler, and a robotic pipette tip loader. It can automate cDNA synthesis from RNA or single cells as well as library construction from cDNA or gDNA. DNA-seq libraries can be prepared using the Nextflex Rapid XP DNA-seq kit.

Feb 11, 2020

Living DNA African Ancestry DNA Test Report

Living DNA, a direct-to-consumer genealogy DNA service, has launched an African ancestry DNA test report that covers 72 regions in Africa. Living DNA said that its report offer five times the African ancestry coverage of any other test, and has been specially designed for African Americans and African Europeans who are researching their roots. The test combines recent ancestry breakdown (last 1,000 years) with deep direct maternal and paternal histories, as well as rich information about the regions from which customers' ancestors originate, covering geography, languages, traditions, and culture. All existing customers with African ancestry can log into their results platform and choose to update their results free of charge, the company said. New customers can purchase a test on offer for Black History Month for $79.

Feb 07, 2020

CDI Labs HuScan and VirScan

CDI Laboratories' Antygen Division, which provides contract research for R&D in the therapeutic and diagnostic space, has launched two biomarker discovery assays, HuScan and VirScan. HuScan detects antibodies against the entire human proteome via long peptides on the surface of bacteriophages, antibody pulldown, and sequencing readouts. VirScan detect antibodies against the proteomes of every viral strain known to infect humans in the same manner. Both assays represent the first commercial use of PhIP-seq technology, the company said.

Feb 06, 2020

CeGaT Exome Xtra

CeGaT has launched the CeGaT Exome Xtra test, which the firm says increases the diagnostic yield compared to a standard exome test. Besides coding sequences, it includes all medically relevant regions throughout the genome, such as pathogenic and likely pathogenic intronic variants, disease-associated transcripts, cryptic exons, as well as the mitochondrial genome. In addition, the data analysis considers variants in genes with reduced penetrance, variable expressivity, imprinting effects, and SNV/CNV combinations.

Feb 06, 2020

Thermo Fisher Scientific Ion Torrent CarrierSeq ECS Kit

Thermo Fisher Scientific has introduced the Ion Torrent CarrierSeq ECS Kit for expanded carrier screening. The AmpliSeq-based panel, which runs on the Ion GeneStudio S5 sequencer, covers 420 genes, including difficult-to-sequence ones like SMN1 and SMN2 for spinal muscular atrophy, GBA for Gaucher disease, CYP21A2 for 21-hydroxylase deficient congenital adrenal hyperplasia, and HBA1 and HBA2 for alpha thalassemia. It detects more than 28,000 non-benign ClinVar variants, including single nucleotide variants and copy number variants, and comes with customizable Carrier Reporter software.

Feb 05, 2020

Hologic Panther Scalable Solutions

Hologic launched new products in the US and Europe within its Panther Scalable Solutions portfolio, in which the firm's molecular diagnostic Panther system functions as the foundation for optional add-ons. The add-on components include Panther Fusion, which launched in 2016 and provides additional IVD menu and an Open Access functionality; Panther Plus and Panther Link, which are now available; and Panther Trax, which is in development.

With Panther Plus, labs can load more consumables directly on the instrument, allowing up to 13.5 consecutive hours of walk-away time. Panther Link is a software solution that provides additional efficiencies by creating a virtual connection that allows multiple Panther instruments to communicate with one another and function within a singular, streamlined workflow. Panther Trax is being developed to physically and electronically link multiple Panther instruments into a single workcell.

Feb 05, 2020

Bio-Techne Next-Generation ELISA Kits

Bio-Techne has launched its Quantikine QuicKit next-generation ELISA product line, which expands the capabilities of its legacy Quantikine ELISA kits. According to Bio-Techne, the kit enables researchers to accomplish more in their day without compromising quality. It enables quantitation of proteins in serum, plasma, and cell supernates in 90 minutes.

Jan 29, 2020

NIPD Genetics Veragene

NIPD Genetics has expanded its Veragene noninvasive prenatal test. The new version of the assay, which covers aneuploidies, microdeletions, and monogenic diseases, is able to identify 2,000 mutations in 99 genes involved in 100 monogenic autosomal recessive and X-linked disorders.  

Jan 27, 2020

Swift Biosciences, Opentrons Labworks Automated 2S Turbo DNA Library Preparation

Swift Biosciences and Opentrons Labworks have launched pre-scripted, automated protocols for the Swift 2S Turbo DNA library preparation kit on the Opentrons OT-2 liquid handler. The protocol can be combined with the Swift Deceleration Module to obtain longer fragments of 550 bp, control fragmentation time on automation platforms, or adjust sample elution buffer.

Jan 27, 2020

Agilent SureSelect XT HS2 DNA Kit

Agilent Technologies has launched its SureSelect XT HS2 DNA kit, which it said will offer researchers a complete solution to choose workflow options. The firm said the kit allows users to multiplex hundreds of samples in one sequencing run, remove sample contamination by indexing from reads, and improve error correction to detect variants with low allele frequencies. 

Jan 27, 2020

Qiagen QCI Precision Insights

Qiagen has launched Qiagen QCI Precision Insights in Europe. QCI Precision Insights is a clinical interpretation service provided by a team of molecular biologists and oncologists who translate patient-specific molecular data into clinical insights and therapeutic options. The new offering includes European Society for Medical Oncology (ESMO) guidelines and the European Medicines Agency (EMA)-approved oncology drugs catalog. Qiagen said that the service enables molecular pathologists and oncologists in Europe to confidently match complex genomic test data to relevant, geographically matched treatment options in minutes for evidence-based, individualized treatment recommendations.

Jan 23, 2020

Integrated DNA Technologies xGen Exome Research Panel v2

Integrated DNA Technologies has launched the xGen Exome Research Panel v2. The next-generation sequencing panel offers improved on-target rates and uniformityincreased sample coverage, updated content, and enhanced performance. The retail price is $8 per sample, which IDT said is a reduction of more than 50 percent compared to the previous version. Each of the panel's 415,115 probes are individually synthesized on IDT's newest platform, Gemini, and manufactured for one large synthesis lot to ensure reproducible results and avoid lot-to-lot revalidations. Potential applications for the assays include population studies, rare disease research, and oncology, IDT said.

Jan 23, 2020

Meridian Bioscience High-Specificity Pfu HS Mix

Meridian Bioscience launched a High-Specificity Pfu Hs Mix to provide high-fidelity amplification for companion diagnostic and clinical testing. The solution cuts down on the possibility of uneven amplification of diverse types of sequences. Meridian said the mix has "market-leading" properties in terms of inhibitor resistance, multiplexing, and low GC bias and can be used in next-generation sequencing and PCR applications. 

Jan 21, 2020

OptraHealth GeneFax Pro

OptraHealth has introduced a version of GeneFax Pro on the Microsoft Azure Marketplace. GeneFax Pro is a conversational chatbot program featuring natural-language processing and artificial intelligence to educate patients about genetic testing, gauge interest in specific tests, and automate pre-test counseling and patient consent. 

Jan 17, 2020

MGI Tech DNBSEQ-G400 FAST

MGI Tech has launched the DNBSEQ-G400 FAST next-generation sequencer in China and Japan. The G400 is also known as MGISEQ-2000 in China and some other markets.

The G400 FAST is a mid-throughput instrument offering maximum output of 330 gigabases for applications including targeted NGS, single-cell sequencing, and whole-genome and -exome sequencing.

The instrument offers two lanes with 550 million effective reads per flow cell. The average run time is between 12 and 37 hours.  Maximum read length is PE150.

Jan 17, 2020

MGI One Million Genomes Total Solution

MGI has released One Million Genomes Total Solution, a software and hardware solution for large-scale population genome sequencing projects that combines sample preparation, high-throughput sequencing, and data analysis. The package consists of a whole-blood pretreatment system that has an annual output of up to 600,000 samples, an automated library preparation system with an annual output of up to 500,000 samples, and MGI's ultra-high-throughput DNBSEQ-T7 sequencer that can sequence 600,000 to 800,000 samples per year. It also includes a data processing platform with computing and storage capabilities that can analyze 100,000 to 1 million samples per year. In addition, the solution integrates a laboratory management system. It uses blockchain technology for data security and privacy.

Jan 17, 2020

Oxford Nanopore Technologies R10.3 Nanopore Chemistry

Oxford Nanopore Technologies has released flow cells using the R10.3 nanopore chemistry. It is currently available for MinIon and PromethIon sequencers and will be available for Flongle flow cells at a later time. The R10.3 chemistry, which is suitable for use with the LSK109 kit at launch, improves on the R10. Like the R10, it uses a pore with a longer barrel and a dual reader head, which improves resolution of homopolymers and consensus accuracy. Compared to the R10, it has increased throughput and capture, is compatible with PromethIon flow cells, has input amounts closer to the R9.4.1 chemistry, and has improved raw accuracy to match the R9.4.1 and to support enhanced variant calling.

Jan 14, 2020

Congenica Neuro

Congenica has introduced Congenica Neuro, a module for the company's clinical decision support platform to help physicians characterize epilepsy and neurodevelopmental disorders. The technology automates prioritization of genetic variants and helps accelerate the identification, review, and reporting of de novo variants by comparing test results to curated gene panels and preconfigured filters, the company said. 

Jan 14, 2020

Biocept Target Selector for CSF

Biocept's Target Selector liquid biopsy assays are now available to physicians to evaluate patients' cerebrospinal fluid for the presence of circulating tumor cells and biomarkers for patients with breast or lung cancer suspected of brain or central nervous system metastases. The presences of such cells may indicate brain metastases. Biocept said that up to 30 percent of patients with breast cancer and up to 36 percent of patients with lung cancer will develop brain metastases.  

Jan 14, 2020

Oxford Gene Technology SureSeq CLL + CNV Panel

Oxford Gene Technology has launched the SureSeq CLL + CNV Panel for cancer research. The next-generation sequencing assay has been designed in collaboration with cancer experts to detect 12 key genes and five chromosomal regions implicated in chronic lymphocytic leukemia (CLL) progression.

The panel alleviates the burden of running multiple assays and delivers a comprehensive genomic profile for each CLL sample using a single workflow. It can identify loss of heterozygosity, copy number variation with a size range of a single exon to the whole gene, loss of chromosomal arms, and whole chromosome gains in trisomy 12. It comes with complimentary data analysis software.

Jan 14, 2020

Genome Diagnostics NGSengine

Genome Diagnostics has released a new version of its NGSengine human leukocyte antigen typing software. The updated NGSengine is now capable of exporting HLA typing results of individual samples directly to the Predicted Indirectly Recognizable HLA Epitopes (PIRCHE) matching-services website, thanks to a recent partnership between Netherlands-based GenDx and German firm PIRCHE. This, the company said, will give laboratories the ability to predict indirectly recognizable HLA epitopes for either hematopoietic stem cells or solid organs.

Pages

New analyses indicate female researchers are publishing less during the coronavirus pandemic than male researchers, according to Nature News.

A study suggests people with the ApoE e4 genotype may be more likely to have severe COVID-19 than those with other genotypes, the Guardian says.

Direct-to-consumer genetic testing companies are searching for a genetic reason for why some people, but not others, become gravely ill with COVID-19, the Detroit Free Press reports.

In PNAS this week: forward genetics-base analysis of retinal development, interactions of T cell receptors with neoantigens in colorectal cancer, and more.