New Products

Jul 18, 2017

Empirical Bioscience 2X qPCR Probe Master Mix

Empirical Bioscience has released 2X qPCR Probe Master Mix for probe-based quantitative PCR applications. This new product is for real-time evaluation of DNA using fluorescent probe-based detection. It contains FlashTaq HotStart DNA polymerase, a chemically modified Taq DNA polymerase that remains inactive at room temperature but becomes activated after 2 minutes at 95° C. The master mix also contains dNTPs, MgCL2, and optimized buffer for fast, efficient qPCR. It has been optimized for use with hydrolysis-based probes such as TaqMan, but is also suitable with other probe-based detection systems. The mix is available in multiple versions for various applications including bulk and custom volumes for commercial and biotech.
Jul 18, 2017

Seraseq Circulating Tumor DNA v2 Reference Materials

SeraCare Life Sciences has launched a new set of ctDNA reference materials to aid development and validation of liquid biopsy assays. The new Seraseq Circulating Tumor DNA v2 reference materials were produced using a unique technology that produces a DNA fragment size-distribution which closely mimics native cfDNA, while decreasing DNA damage relative to ultrasonicated material, the company said.

The new product requires no special workflow considerations to generate informative data, and contains 40 somatic mutations, including important targets like BRAF V600E, KRAS G12D, and various EGFR alterations. Variants are present against a single well-characterized genomic background across a range of allele frequencies down to 0.125 percent, which ensures utility for assays with different limits of detection.

Jul 14, 2017

UCSF mNGS Test

The University of California, San Francisco's Center for Next-Gen Precision Diagnostics has launched a metagenomic next-generation sequencing test for neurological infections. Physicians can order the test for patients with idiopathic meningitis or encephalitis with unknown etiology. Testing is performed on cerebrospinal fluid. The testing process takes around 72 hours and results are reported back within one to two weeks. Charles Chiu, director of UCSF's Viral Diagnostics and Discovery Center, most recently described the test at a conference in February.

Jul 14, 2017

Biocept Progesterone Receptor Liquid Biopsy Test

Biocept has announced the commercial availability of its liquid biopsy test for progesterone receptor (PR), which can be used for the detection and monitoring of a key biomarker in the blood of patients with breast cancer. The company noted that the ability to detect PR expression in circulating tumor cells complements its existing ER and HER2 assays for biomarker analysis in breast cancer. Biocept's Target Selector PR expression test is performed on circulating tumor cells using fluorescently labeled antibodies. The company's liquid biopsy tests are performed in its CLIA-certified, CAP-accredited laboratory in San Diego.

Jul 12, 2017

Norgen Small RNA Library Prep Kit and Sequencing Services

Norgen Biotek, based in Ontario, has launched a Small RNA Library Prep Kit for Illumina sequencing instruments as well as sequencing services on Illumina instruments. The Small RNA Library Prep Kit needs between 0.5 nanograms and 1 nanogram of input RNA and can process samples from plasma, serum, blood, cerebral spinal fluid, urine, and exosomes, according to the company. Turnaround time is less than five hours. Norgen also offers complementary products, including NGS-compatible cel-miR-39 spike-in and an NGS library quantification kit. The services Norgen launched include isolation, library prep, sequencing, and bioinformatics. Sequencing can be performed on Illumina's MiSeq or NextSeq 500 instruments and includes small RNA-seq, RNA-seq, 16S metagenomics, targeted DNA or RNA sequencing, exome sequencing, and whole-genome sequencing.  

Jul 12, 2017

Exact Diagnostics Verification Panels

Exact Diagnostics launched its verification panels for IVD use. The panels include adenovirus; BKV; CMV; EBV; HBV; HCV; HHV-6A; HHV-6B; HIV-1; HSV-1; HSV-2; VZV; and Zika. They can be used to establish reference points to measure various analytes in molecular assays, the firm said. 

Jul 07, 2017

LGC High-Throughput Liquid Handling for PCR

LGC has launched the Meridian2 liquid dispensing system, a non-contact, on-the-fly dispenser suited to a wide range of dispensing applications, including reagents for genotyping and standard PCR. The Meridian2 features two plate positions for enhanced efficiency, integrated barcode reading, and automated assay mixing. It integrates into laboratories with existing SNPline automation or other Meridian instruments. The platform accurately dispenses 1-μL volumes into a 1,536-well plates in less than 45 seconds, with a CV of less than 5 percent, and the vacuum-based aspiration system allows multi-plate dispense for increased efficiency.

Jul 07, 2017

Li-Cor Biosciences D-DiGit Gel Scanner

Li-Cor Biosciences has launched the LED-based D-DiGit Gel Scanner, designed to help researchers eliminate the risk of ethidium bromide exposure and workspace contamination from their nucleic acid gel analysis experiments. The new system enables safe and convenient detection of DNA and RNA samples stained with fluorescent safe stains, like SYBR Safe, which are sensitive and environmentally friendly alternatives to ethidium bromide. Added either during gel preparation, or as a post-electrophoresis stain, safe stains eliminate the need for hazardous disposal and hassles associated with ethidium bromide. The D-DiGit improves protocol efficiency by consolidating nucleic acid analysis on a single system dedicated to high-sensitivity gel imaging. The scanner provides a large scan area to visualize most medium and larger format gels. Nucleic acid band extraction and imaging can be performed directly on the scan surface, the company said.

Jul 06, 2017

MDxHealth AssureMDx for Bladder Cancer Liquid Biopsy Test

MDxHealth has launched its AssureMDx for Bladder Cancer liquid biopsy test in the US as a laboratory-developed test. AssureMDx is a non-invasive, urine-based test. It searches for methylation and mutation biomarkers in order to assess the risk of bladder cancer for patients diagnosed with hematuria. The test's 93 percent sensitivity and 85 percent specificity can help doctors identify patients at increased risk for bladder cancer, who may benefit from cystoscopy, the company said. Testing will be conducted at MDxHealth's CAP- and CLIA-accredited lab in Irvine, California.

Jun 29, 2017

HTG Molecular Diagnostics GEP Assay

HTG Molecular Diagnostics launched the EdgeSeq Path Assay in the US and Europe. The assay is designed for retrospective gene expression profiling to complement immunohistochemistry testing. It allows investigators to assess mRNA expression of large numbers of biomarkers when there's limited availability of formalin-fixed, paraffin-embedded samples.

Jun 28, 2017

Canopy Biosciences Gene Expression Analysis Service

Canopy Biosciences has launched a service for high-throughput gene-expression analysis. Based on the NanoString nCounter platform, the service works with a large array of sample types, including formalin-fixed paraffin-embedded tissue. Canopy has paired this service with genome editing capabilities enabled by its recent licensing of TUNR flexible gene editing technology from Washington University in St. Louis and Johns Hopkins University. The new service features a web-based ordering tool, through which researchers can choose one of NanoString's pre-made gene panels or design their own custom panel. Each panel enables the simultaneous measurement of over 700 genes, Canopy said.

Jun 28, 2017

Roche Harmony NIPT 22q11.2 Deletion

Roche has added 22q11.2 deletion testing to the Harmony Prenatal Test menu, allowing laboratories and physicians using the test to screen for 22q11.2 deletion syndrome, which is associated with heart defects, poor immune system function, cleft palate, and delayed development. The 22q11.2 deletion is estimated to occur in one out of every 2,000 to 4,000 live births.

Jun 28, 2017

Bioarray PGS+PGD Single Biopsy Kit

Bioarray has launched its PGS+PGD Single Biopsy kit which screens aneuploidies and identifies embryos with pathological mutation from a single biopsy sample. The kit uses next-generation sequencing technology and bioinformatics analysis to determine whether an embryo carries aneuploidies, such as trisomy of chromosome 21, and allow for users to reject embryos affected by the mutation and/or select those not affected. Users can expect results to be processed within three to five days.

Jun 27, 2017

DNANexus Mosaic Microbiome Research Platform

Working with the Janssen Human Microbiome Institute, DNANexus has introduced Mosaic, a cloud-based informatics platform to support collaboration on research into the human microbiome. DNANexus is positioning Mosaic as a "virtual ecosystem and innovation accelerator" for academic medical centers, biotech and pharmaceutical companies, technology vendors, and government regulators.

Jun 27, 2017

SeraCare iQ NGS QC Management v2

SeraCare Life Sciences has launched version two of its iQ NGS QC Management software. The software supports laboratories' workflows from sample preparation to variant calling enabling lab managers to review and assess run performance, determine run pass or fail status, and identify potential sources of assay drift that could cause problems, according to the company. The software also generates a report that can be used for audits or inspections. The software integrates with existing data systems like Illumina BaseSpace and LIMS.

Jun 26, 2017

Oxford Nanopore PCR-cDNA and Direct cDNA Sequencing Kits

Oxford Nanopore Technologies has launched a PCR-cDNA Sequencing kit and a Direct cDNA Sequencing kit to prepare cDNA for nanopore sequencing. The PCR-cDNA kit requires a minimum input of 50 nanograms of RNA and the Direct cDNA kit requires at least 250 nanograms of RNA. Both kits can be used on any RNA with a polyA tail, and both are compatible with barcoding kits to multiplex samples.

Jun 26, 2017

Premaitha Health Updated Iona Test

Premaitha Health has updated its Iona noninvasive prenatal test, which now includes the first trimester combined test risk score as an option in its software. The company said that it completed a validation study to show that the Iona test in combination with the first trimester combined screen was as accurate as estimating prior risk using maternal age.

Jun 26, 2017

BloodCenter of Wisconsin's Diagnostic Laboratories hematology test panels

BloodCenter of Wisconsin's Diagnostic Laboratories launched seven hematology genetics test panels. The new panels include nonmalignant hematology disorders, such as platelet function disorders, inherited thrombocytopenia, and congenital neutropenias.  

Jun 22, 2017

Bio-Rad Droplet Digital PCR-Based Assays

Bio-Rad Laboratories has launched droplet digital PCR Genome Edit Detection assays, which can characterize edits generated by CRISPR-Cas9 or other genome editing tools. The assays use ddPCR technology which increases the signal-to-noise ratio, allowing users to quantify extremely rare edits, even those with frequencies of 0.5 percent and from as little as 5 nanograms of genomic DNA. Users can expect to obtain results within one day.

Jun 21, 2017

Children's Hospital Los Angeles OncoKids

Children's Hospital Los Angeles has launched OncoKids, a next-generation sequencing-based panel that detects mutations, gene amplification, and gene fusions for a full range of pediatric cancers including leukemias, bone and soft tissue tumors, and brain tumors. It only requires a small amount of DNA and RNA (20ng) isolated from fresh, frozen, or formalin-fixed paraffin-embedded tissue. The test was developed in collaboration with Thermo Fisher Scientific and uses the Ion Torrent S5 sequencing platform and Ion AmpliSeq technology.

Jun 19, 2017

Thermo Fisher Scientific ISQ EC Single Quadrupole Mass Spectrometer, MabPac RP 1mm Columns

Thermo Fisher Scientific has launched a new mass spectrometer and new chromatography columns. The ISQ EC Single Quadrupole mass spectrometer integrates with existing ion chromatography and HPLC systems, and the Chromeleon Chromatography Data Software has instrument control for the new mass spec embedded. The MabPac RP 1mm columns are designed for analyzing monoclonal antibodies, fragments, variants, antibody drug conjugates, and proteins using high-performance reversed-phase chromatography. They can operate with small sample volumes at low flow rates for direct injection into a mass spectrometer.

Jun 16, 2017

Premaitha Sage Prenatal Screening Solution

Premaitha Health has launched Sage, a noninvasive prenatal testing solution. The test uses the latest technology to detect placental DNA in maternal blood sample, and uses the company's cloud-based bioinformatics analysis to allow laboratories to upload sequencing data files to the cloud for remote analysis. The panel includes full chromosome analysis. The testing will be available through Yourgene Bioscience Singapore, which was acquired by Premaitha in March.

Jun 15, 2017

TATAA Biocenter GrandPeformance Assays

TATAA Biocenter has launched GrandPerformance assays for expression profiling single circulating tumor cells. The assays' workflow is based on preamplification allowing precise measurements of 96 specific expression markers per cell. They are also optimized for single-cell sensitivity.

Jun 15, 2017

Integrated DNA RhAmp SNP Genotyping Solution

Integrated DNA Technologies has launched its rhAmp SNP Genotyping system to enable researchers to make quick, confident, and cost-effective SNP calls. The system is a single-tube assay that uses a unique RNase H2/DNA polymerase two-enzyme system coupled with RNA-DNA hybrid primers to eliminate non-specific amplification. It also uses primer dimer formation, can be fully automated, and is designed to work on all leading commercially available qPCR platforms.

Jun 14, 2017

Bio-Rad CFX Maestro Software

Bio-Rad Laboratories has launched CFX Maestro Software for CFX Real-Time instruments. It is a complete workflow solution for real-time PCR data collection and analysis that enables researchers to set up and run qPCR experiments with ease, the company said. The software includes tools to support reference gene selection, efficiency-corrected relative normalization, data visualization, statistics, and multiplate analysis.

Pages

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.

A former Synthetic Genomics attorney alleges that the firm discriminated against her and other female employees, according to the San Diego Union-Tribune.

Due to privacy and lab certification questions, the planned giveaway of Orig3n testing kits at a Baltimore Ravens game was suspended.