New Products

Nov 27, 2017

Roche HyperCap Target Enrichment Portfolio

Roche has launched its HyperCap Target Enrichment Portfolio, for streamlined and fully integrated next-generation sequencing sample preparation. HyperCap integrates KAPA DNA Library Prep with the SeqCap EZ target enrichment portfolio, and is a further expansion of the HyperCap v1.0 workflow. As part of the new launch, Roche is also introducing Universal Blocking Oligos, which prevent cross-hybridization between adapter sequences in capture experiments.

Nov 27, 2017

Thermo Fisher Scientific Expanded Invitrogen TrueEdit Tool Kit

Thermo Fisher Scientific has expanded its Invitrogen TrueEdit tool kit. The portfolio now includes the Invitrogen TrueCut Cas9 Protein v2, a recombinant Streptococcus pyogenes Cas9 protein for genome editing with CRISPR technology. This CRISPR-Cas9 protein is designed to deliver consistently high editing efficiency in all cell lines including standard, immune, primary, and stem.
 
In addition, the firm's new product line of ready-to-transfect Invitrogen TrueGuide Synthetic gRNAs offers researchers a range of selections, from economical options for routine editing tasks to high-performance choices for editing in challenging cell types such as primary cells, immune cells, and stem cells. Thermo Fisher also offers predesigned synthetic gRNAs for the entire human and mouse genome, selected for maximum knockout efficiency and specificity.
Nov 17, 2017

Covaris 96 OneTUBE-10 Adaptive Focused Acoustics Plate

Covaris has released the 96 OneTUBE-10 AFA Plate, which uses the company's Adaptive Focused Acoustics technology to eliminate mechanical DNA shearing in the next-generation sequencing library prep workflow through end repair, A-tailing, ligation, and SPRI cleanup. OneTUBE-10 is specifically designed for use with Covaris' AFA technology for DNA shearing at volumes of 10 to 50 µL; is compatible with standard heat blocks, magnets, and thermocyclers; and can be used on any liquid-handling platform, the company said.

Nov 17, 2017

Canon BioMedical Novallele Copy Number Assays for SMA Research

Canon BioMedical has launched Novallele copy number assays for spinal muscular atrophy research. The PCR-based method only requires a thermocycler capable of high-resolution melting (HRM) and a single sample replicate. The assays are optimized to work with multiple HRM-capable thermocyclers and numerous DNA extraction methods. With some thermocyclers, results can be generated in under an hour, Canon said.

Nov 16, 2017

Edico Dragen Clinical Genomics Information System

Edico Genome has introduced the Dragen Clinical Genomics Information System, software designed to help clinical laboratories develop sequencing-based tests. Dragen CGIS is meant to integrate Edico's various somatic, germline, joint genotyping, and RNA gene fusion pipelines with various other systems Edico has partnered with, including Fabric Genomics' Opal Clinical genome interpretation software.

Nov 16, 2017

True Health Respiratory Pathogen Screening

True Health launched the respiratory pathogen screening, a single test that targets 21 viral and bacterial pathogens to help clinicians determine the correct treatment for respiratory illnesses during cold and flu season. True Health's program is built to identify the specific cause of the infection so clinicians can prescribe an effective treatment. The 21-pathogen screen has a one day turn around from receipt of the specimen at the lab to delivering the results. The screen is conducted using multiplex PCR.

Nov 15, 2017

Circulogene Microsatellite Instability Biomarker Testing

Circulogene announced the availability of microsatellite instability biomarker testing for multiple cancer types. The test is immediately available to oncologists and pathologists, enabling them to identify patients eligible for treatment with Keytruda (pembrolizumab) across multiple cancer types, or Opdivo (nivolumab) for colorectal cancer. With the new assay, Circulogene now provides circulating DNA, RNA, and MSI cancer immunotherapy testing from a single tube of blood with a three-day turnaround time out of it CLIA-certified laboratory.

Nov 15, 2017

Promega Maxwell Modular Automated Nucleic Acid Prep System

Promega has launched a modular automated liquid-handling and purification system for its Maxwell nucleic acid preparation platform. The configurable system works with existing Promega Maxwell RSC instruments with a software upgrade. The Promega Portal Software allows the new and existing Maxwell RSC and Maxprep instruments to work together to transfer sample tracking information. Data can also be imported into a laboratory information management system. The Maxwell RSC 48 and Maxprep Liquid Handler are supplied with preprogrammed methods that allow the system to be used by anyone in the lab regardless of prior instrumentation experience, Promega said.

Nov 14, 2017

InSource Diagnostic ToxLok

InSource Diagnostic launched ToxLok for the verification of urine-based drug tests. ToxLok uses a buccal swab along with the urine sample, and DNA markers from the swab and urine are matched. The test can identify synthetic urine and samples that may be from a friend or relative. ToxLok uses 52 genetic markers to identify each patient and urine sample. Analysis is done by qPCR and MALDI-TOF mass spectrometry. 

Nov 14, 2017

IQuity IsolateIBS-IBD

IQuity launched its IsolateIBS-IBD blood-based test for the identification of irritable bowel syndrom or inflammatory bowel disease. The Nashville, Tennessee-based company said the test can determine IBS and IBD earlier than is possible with other tests and has accuracy greater than 90 percent. It can determine whether a person's RNA profile indicates the presence of IBS or IBD, and within IBD it provides information to differentiate between Crohn's disease and ulcerative colitis. 

Nov 14, 2017

Horizon Discovery Edit-R CRISPRa Reagent Platform for Genome-Wide CRISPR Activation

Horizon Discovery has launched its reagent platform for CRISPR activation as the latest addition to the company's Edit-R portfolio for CRISPR-Cas9 genome engineering. The new Edit-R CRISPRa offering provides researchers interested in gain-of-function studies with a two-component system for drug discovery, disease modeling, or pathway analysis. The system is available in lentiviral and synthetic formats and is well-suited for robust overexpression in virtually any cell system, Horizon said. This format is also suitable for arrayed studies for high-throughput, complex phenotypic analysis.

The Edit-R CRISPRa portfolio includes genome-wide, pre-designed guide RNAs for human and mouse, as either a lentiviral expression plasmid, lentiviral particles, or a two-part synthetic guide RNA. The system further utilizes nuclease-deactivated Cas9 fused to three activation domains provided as lentiviral particles or purified plasmids.

Nov 13, 2017

Canopy Biosciences CRISPR Complete Gene Editing Kits

Canopy Biosciences has launched its CRISPR Complete Gene Editing Kits, which include everything a researcher needs to perform a gene editing experiment with the CRISPR-Cas9 system. Pricing for the kits start at $990 for a gene knockout kit. Kits are available for knockouts, knock-ins, point mutations, and many other project types, and include both design and synthesis of crRNAs, tracrRNA, Cas9 protein, genotyping primers, and donor (for knock-ins and point mutations).

Nov 10, 2017

TwistDx TwistAmp Liquid Kits

TwistDx recently launched TwistAmp Liquid kits, a range of liquid format recombinase polymerase amplification kits ideal for rapid testing applications and high-throughput laboratory use. RPA is an isothermal DNA/RNA amplification technology that the company says offers the same specificity as PCR but with much faster results – typically within three to 10 minutes.

The new kits are designed to simplify integration of RPA technology into existing laboratory workflows. The liquid format also simplifies the development of miniaturized or custom assay configurations and the creation of bulk master mixes, TwistDx said.

Nov 09, 2017

BioDiscovery NxClinical 4.0

BioDiscovery recently launched NxClinical 4.0, software for the interrogation of copy number, sequence variants, and allelic changes obtained from a single next-generation sequencing assay. The software incorporates all these genomic variations into a single database where a compound heterozygous event can easily be detected with interactive browser view and advanced filtering schemas that quickly narrow down the list of potential causal variants, the company said.

Nov 09, 2017

MedReleaf ReleafDx

Canadian medical cannabis firm MedReleaf is launching in that country ReleafDx, a genetic test to help physicians in the prescription of cannabis. Based on a cheek swab, the test analyzes a patient's DNA and health conditions, providing information that a doctor can use to determine what cannabis product will work best for an individual, and the proper dosage. Dynacare, a Laboratory Corporation of America company, will manage the sample analysis and results reporting. The cheek swab can be done in doctors' offices or at a Dynacare Laboratory and Health Services Centre. The samples are then sent to Dynacare for analysis. Results are returned to the doctor with recommendations on the proper dosage of medReleaf's products. The test will be available in Canada starting in January.

Nov 08, 2017

3dbiosurfaces, Stratec Consumables 3D NS-NC slide

3dbiosurfaces and Stratec Consumables have launched the 3D NS-NC slide, a microarray substrate based on 3dbiosurfaces' technology. Stratec Consumables is a wholly owned subsidiary of Stratec. The slide offers increased signal intensity, more uniform spots, and other benefits over other microarray substrates, the firms said in a statement, adding it is especially attractive for protein applications as the surfaces allow proteins to maintain their shape and function.

Nov 08, 2017

New England Biolabs NEBNext Ultra II FS DNA Library Prep Kit

New England Biolabs has launched the NEBNext Ultra II FS Library Prep Kit for enzyme-based DNA fragmentation and library preparation for next-generation sequencing. The kit combines fragmentation, end repair, and dA-tailing in a single tube. Input DNA amounts can range from 100 picograms to 0.5 micrograms and library preparation can be completed in 2.5 hours, with less than 15 minutes of hands-on time. The kit is also available with SPRISelect beads for size selection and cleanup steps.

Nov 08, 2017

SeraCare's Seraseq Myeloid Mutation DNA Mix and Myeloid RNA Fusion Mix

SeraCare Life Sciences has launched next-generation sequencing reference material for hematologic malignancies. The Seraseq Myeloid Mutation DNA Mix and Myeloid RNA Fusion Mix include mutation types from SNVs to gene fusions. The products contain 23 DNA mutations and nine fusion RNAs that are present against a well-characterized genomic background at clinically relevant allele frequencies. The products are designed to help clinical labs that perform NGS-based testing of myeloid malignancies to characterize their assays.

Nov 08, 2017

Invivoscribe LymphoTrack TRB Assay

Invivoscribe has released the research use-only version of its LymphoTrack TRB Assay for the Illumina MiSeq sequencing platform. The assay dentifies clonal TRB (VDJ) rearrangements, the associated VDJ region DNA sequences, and provides the frequency distribution of V, D, and J region segment utilization using the included LymphoTrack bioinformatics software. This software allows researchers and pharmaceutical companies conducting clinical trials to identify amd track clonal populations by performing minimal residual disease testing of subsequent samples.

Nov 08, 2017

Dolomite Bio Nadia Single-Cell RNA Sequencing Platform

Dolomite Bio has launched its Nadia single-cell platform for single-cell RNA sequencing. It is a droplet-based microfluidic instrument that can generate up to 6,000 single-cell libraries per sample in around 15 minutes. Researchers can run one, two, four, or eight samples in parallel. 

Nov 07, 2017

Definiens IO-Panel

Definiens now offers its Immuno-Oncology Panel (IO-Panel) as part of its "Insights" services portfolio. The IO-Panel is designed to enable pharmaceutical immuno-oncology researchers to advance tissue-biomarker-dependent drug development and speed up clinical research. It combines Definiens' digital image analysis capabilites, powered by Tissue-Phenomics technology, which quantifies relevant spatial relations of different immuno and tumor cells within the context of the complete tissue architecture and tumor heterogeneity, the company said.

Nov 02, 2017

Thermo Fisher Scientific MagMax DNA Multi-Sample Ultra 2.0

Thermo Fisher Scientific has released MagMax DNA Multi-Sample Ultra 2.0 reagents for DNA extraction from blood, saliva, buffy coat, and buccal swabs. With Thermo Scientific KingFisher instruments, customers can use the reagents to purify DNA from 96 samples in 45 minutes, with five minutes of hands-on time, using a protocol for either small-volume or large-volume samples. 

Oct 31, 2017

MGI Tech MGISEQ-2000, MGISEQ-200 Sequencers; MGIFLP Modular NGS Workstation; MGIUS-R3 Robotic Ultrasound System

MGI Tech, a subsidiary of BGI, has launched two next-generation sequencing platforms, MGISEQ-2000 and MGISEQ-200; a modular NGS workstation, MGIFLP; and a robotic ultrasound system, MGIUS-R3.

The MGISEQ-200 and -2000 instruments are upgrades to the BGISEQ-50 and -500 platforms, respectively. Improvements include changes in design and an optimized chemistry that allows customers to run the sequencers at a lower cost. Both instruments can run with at least four different read lengths and can complete a run with 100-base paired-end reads in less than 48 hours. The platforms can be ordered starting December 25 and will start shipping February 14, initially in China.

Oct 31, 2017

Admera Health PGxOnco and LiquidGx Tests

Admera Health has launched two new tests: PGxOnco for cancer supportive care, and LiquidGx, a suite of liquid biopsy-based tests for tumor profiling and drug resistance monitoring. The PGxOnco test includes 50 genes and about 200 variants, and provides recommendations for over 300 drugs via next-generation sequencing. LiquidGx represents a menu of both qPCR and a NGS tests that analyze tumor DNA in blood samples. PCR assays allows for the genotyping of ALK, BRAF, EGFR, and KRAS either individually or together. The NGS panel, aimed specifically at lung cancer, includes AKT1, BRAF, ERBB2, MET, RET, ALK, EGFR, KRAS, PIK3CA,and ROS1.

Oct 30, 2017

Cancer Genetics AntigenID

Cancer Genetics has launched a neoantigen discovery service it calls AntigenID designed to identify neoantigens and neoantigen signatures that can accelerate immuno-oncology drug discovery, predict patient-specific immune therapy response, and help create personalized immuno-vaccines. AntigenID incorporates genomic and transcriptomic profiles, HLA typing, and bioinformatic strategies, the company said.

Pages

A phylogenetic analysis indicates two venomous Australian spiders are more closely related than thought, the International Business Times reports.

Technology Review reports that 2017 was the year of consumer genetic testing and that it could spur new analysis companies.

In Science this week: CRISPR-based approach for recording cellular events, and more.

A new company says it will analyze customers' genes to find them a suitable date, though Smithsonian magazine says the science behind it might be shaky.