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Nov 07, 2019

Qiagen QiaSeq Multimodal Panels

Qiagen has launched a new workflow, called QiaSeq Multimodal Panels, for the simultaneous preparation of DNA and RNA libraries for next-generation sequencing. The panels require an input as low as 10 nanograms of total nucleic acid and the workflow takes about nine hours. Both libraries are generated from the same sample and allow for the analysis of DNA variants, RNA fusions, and gene expression levels.

Nov 07, 2019

Lifebit Biotech CloudOS

Lifebit Biotech has introduced Lifebit CloudOS, a cloud-native, federated genomics operating system that supersedes the beta-release Lifebit Deploit from 2017. CloudOS works as a managed service of individual clouds or high-performance computing centers to support analysis of bioinformatics data across sites and institutions. The company said that this system automates analysis and the application of machine learning, removing a major barrier to precision medicine, population, genomics, drug discovery, and direct-to-consumer genetics progress. 

Nov 06, 2019

Genomenon Mastermind 2.0

Genomenon has introduced version 2.0 of its Mastermind genomic search engine. The new release features the ability to search genomic literature by phenotype to help with the diagnosis of rare and hereditary diseases. Genomenon said that this addition was the most requested improvement to the product from children's hospitals and genetic testing laboratories alike. 

Nov 05, 2019

Agena Bioscience VeriDose CYP2D6 CNV Panel

Agena Bioscience has launched the VeriDose CYP2D6 CNV panel to provide PGx testing programs with a more accurate and efficient way to analyze CYP2D6 copy number. The research-use-only panel quantifies CYP2D6 copy number even in the presence of CYP2D6/CYP2D7 hybrid alleles, which cannot be detected by commonly used PGx technologies, the company said. The panel can also be run alongside Agena's PGX genotyping panels.

Nov 05, 2019

Paragon Genomics CleanPlex CFTR Panel

Paragon Genomics this week introduced the CleanPlex CFTR Panel for cystic fibrosis testing. The panel uses the company's CleanPlex target enrichment technology for a multiplex PCR-based targeted sequencing assay to evaluate somatic and germline variants in the CFTR gene. It covers all exons of the gene and includes mutations recommended by the American College of Medical Genetics and Genomics.

Nov 05, 2019

Loop Genomics: Long Read Microbiome Sequencing Service

Loop Genomics has launched a new service for linked read microbiome sequencing for studies with large cohorts. For labs running at least 200 to 1,000 samples, Loop is offering 16S sequencing at a price between $38 and $20 per sample, depending on volume. Loop generates long reads using Illumina's short-read sequencing platform. The firm said it can deliver 40-fold lower error rates and can eliminate false positives, delivering species- and sometimes strain- level taxonomy.

Nov 01, 2019

Genome Medical's Genome Care Delivery

Genome Medical, a telegenomics technology and services company, has launched Genome Care Delivery, a cloud-based platform that provides hospitals, health systems, and employers virtual access to a nationwide network of clinical genetics specialists in order to expedite and facilitate the delivery of genetic expertise. The platform is initially focused on oncology and reproductive health, and is intended to deliver education, engagement, and access to genetic experts for virtual visits and provider-to-provider consults, as well as genetic wellness assessment and screening for population health management, the company said. Features include curated content, adaptive videos, webinars, online assessment tools, virtual care visits with genetic specialists, personalized recommendations regarding genetic testing, and clinical action plans based on genetic test results and medical management guidelines.

Oct 31, 2019

SeraCare SeraSeq TMB gDNA and FFPE Reference Materials

SeraCare Life Sciences has released what it says are the first available genomic DNA and formalin-fixed paraffin-embedded reference materials for tumor mutational burden measurement by next-generation sequencing assays. The company created the new materials as part of its work with the Friends of Cancer Research TMB harmonization working group and the International Quality Network for Pathology's TMB EQA Pilot Program.

Data generated from using the reference samples was presented by FOCR at the 2019 American Society of Clinical Oncology Meeting, and by IQN Path at the 2019 European Congress of Pathology, demonstrating their utility in harmonizing and standardizing measurements of TMB by different NGS assays.

In addition to the new SeraSeq TMB gDNA and FFPE materials available now, SeraCare said it can also create custom tissue and blood-based TMB reference materials through its VariantFlex custom reference material development platform.

Oct 31, 2019

Becton Dickinson Rhapsody Whole-Transcriptome Analysis Amplification Kit

Becton Dickinson has released a new solution for combined whole-transcriptome and protein analysis in single cells.

The BD Rhapsody Whole Transcriptome Analysis Amplification Kit enables unbiased 3'-based capture, amplification, and detection and is designed to work with BD's Rhapsody single-cell analysis system and AbSeq reagents. It is also optimized to work with BD's Single-Cell Multiplexing kit to improve efficiency.

The research-use-only kit is validated for use with a wide range of cell inputs.

Oct 31, 2019

Thermo Fisher Scientific Oncomine Comprehensive Assay Plus

Thermo Fisher Scientific has launched the Oncomine Comprehensive Assay Plus for the detection of targeted and immuno-oncology biomarkers. The assay, designed for solid tumors, covers more than 500 genes and enables analysis of both DNA and RNA in a single workflow. It detects single nucleotide variants, indels, copy number variants, gene fusions, and splice variants and is suitable for microsatellite instability (MSI) and tumor mutational burden (TMB) assessment. The assay requires 1 ng DNA/RNA input and fits seamlessly into existing Thermo Fisher Ion Chef and Ion GeneStudio system workflows.

Oct 31, 2019

Yourgene Flex Analysis Software

Yourgene of Manchester, UK, has launched the Yourgene Flex Analysis Software to support the company's plans to develop next-generation sequencing-based in vitro diagnostic products with partners and research collaborators in industry. The software platform builds on the company's Iona software and will also be deployed internally to support Yourgene's internal product development pipeline in reproductive health and oncology. Its components allow for sequence data to be read, filtered, and analyzed, and to generate bespoke clinical test reports. All elements of the software are developed to standard ISO/IEC 62304, which supports in vitro diagnostic regulatory submissions.

Oct 30, 2019

RareCyte Prostate Cancer RarePlex Staining Kit

RareCyte has launched a new RarePlex Staining Kit for evaluating prostate cancer specific expression of ARv7 on circulating tumor cells. When combined with the firm's CTC analysis platform, the RarePlex ARv7 CTC Panel kit allows researchers to perform first blood-to-result prostate-specific CTC assay in their laboratories. RareCyte said the kit contains CTC detection markers in addition to ARv7 and can be performed on an automated slide staining system. 

Oct 30, 2019

ATCC Cell-Specific Exosomes

ATCC has launched a portfolio of human-derived exosomes to serve as reference materials or standards for a variety of research applications. The firm's first two exosomes available are dervied from the A549 non-small cell lung cancer (NSCLC) cell line and hTERT-immortalized mesenchymal stem cells. 

Oct 29, 2019

DxTerity Diagnostics IFN-1 Test

DxTerity Diagnostics has launched the IFN-1 Test for determining a systemic lupus erythematosus patient's type 1 interferon status and the risk of progressing to lupus nephritis. The firm launched the test after releasing results of a longitudinal clinical study with the Oklahoma Medical Research Foundation, to be presented on Nov. 11 at the American College of Rheumatology annual meeting in Atlanta. The test, DxTerity said, is currently being used to select and monitor patients for SLE clinical trials. While therapies targeting IFN-1 have shown promise in Phase II clinical studies, they have had disappointing results in Phase III randomized trials. The ability to select patients who overexpress IFN-1, based on RNA profiling, is seen as crucial for the future success of clinical trials, DxTerity said. The IFN-1 assay a gene expression module contained within the company's Modular Immune Profile assay, which was developed to measure the relative gene expression of immune system-related genes.

Oct 29, 2019

New England Biolabs NEBNext RNA Depletion Kits

New England Biolabs has launched two new RNA depletion products to support next-generation RNA sequencing.

The NEBNext Globin & rRNA Depletion Kit (human/mouse/rat) depletes adult, fetal, and embryonic globin mRNA (HBA1/2, HBB, HBD, HBM, HBG1/2, HBE1, HBQ1 and HBZ), as well as cytoplasmic rRNA (5S, 5.8S, 18S, 28S, ITS and ETS) and mitochondrial rRNA (12S and 16S).

The NEBNext rRNA Depletion Kit (bacteria) removes the abundant bacterial rRNAs (5S, 16S, and 23S) resulting in the enrichment of bacterial mRNAs and non-coding RNAs of interest. This method is targeted to both gram-positive and gram-negative organisms, and is effective with RNA from monocultures or mixed bacterial species, such as those used in metatranscriptome studies, NEB said.

The new kits complement the NEBNext products for RNA library preparation, including the Ultra II Directional RNA Library Prep Kit for Illumina and the NEBNext Library Quant Kit for Illumina, as well as the Monarch Total RNA Miniprep Kit, the company said.

Oct 25, 2019

NYU Langone Health Perlmutter Cancer Center Clinical Whole-Genome DNA Methylation Profiling for Brain Tumors

NYU Langone Health's Perlmutter Cancer Center has launched clinical whole-genome DNA methylation profiling for patients with brain tumors. This molecular assay utilizes DNA epigenetic signatures and artificial intelligence with machine learning to identify and subtype brain tumors.

The test received New York State Department of Health approval on April 3.  

Oct 25, 2019

Biocartis Idylla ctEGFR Mutation Assay

Biocartis has globally launched its Idylla ctEGFR Mutation Assay. The firm noted that the research-use-only tool is the liquid biopsy version of its solid biopsy Idylla EGFR Mutation Test. Running on the Idylla platform, the assay allows users to detect 49 EGFR mutations directly from 2 ml of blood plasma and provides resutls within 160 minutes, Biocartis said.

Oct 23, 2019

Synthego High-Throughput Induced Pluripotent Stem Cell Genome Engineering

Synthego has launched a genome engineering service for induced pluripotent stem (iPS) cells. The new offering expands on Synthego's automated cell editing technology to achieve high editing efficiency of iPS cells at an industrial scale. Synthego said its cell-editing platform makes editing, cloning, and maintaining high pluripotency in clinically relevant iPS cells easier, with editing rates as high as 90 percent prior to cloning and 100 percent in clones. The new offering of iPS cells includes modifications by gene knockout, single-nucleotide variation, protein tagging, and other knock-ins.

Oct 20, 2019

Sophia Genetics Whole Exome Solution

Sophia Genetics has released a new version of Sophia Whole Exome Solution, which the company said reduces turnaround time for analysis of whole-exome sequences. The updated Sophia WES now features detection of copy-number variations at a resolution of two to five exons without the need for a reference sample. The product also supports analysis of variants in familial trios to filter variants based on different inheritance modes. 

Oct 17, 2019

Illumina Infinium Global Diversity Array

Illumina has launched the Infinium Global Diversity Array, the commercial version of the array designed for use in the National Institutes of Health All of Us research program. The array features about 1.9 million variants, including imputation-optimized tag SNPs and up-to-date clinical research content from public databases such as ClinVar, the National Human Genome Research Institute-EBI database, and Pharmacogenomics Knowledgebase (PharmGKB). The array has broad utility for a variety of large-scale screening and association studies, with content relevant for polygenic risk scoring, common-disease association studies, and inherited risk screening, Illumina said. In addition, the array offers extremely high genomic coverage and imputation performance across 26 diverse populations. It comes in an eight-sample format chip that has room to add up to 175,000 custom beadtypes, the company said.

Oct 17, 2019

Integrated DNA Technologies NGS Discovery Pools

Integrated DNA Technologies this week launched its NGS Discovery Pools, individually synthesized, 5'-biotinylated oligo pools designed to enable researchers to rapidly build custom panels at a fraction of the cost compared to conventional panels. According to the firm, the NGS Discovery Pools offer the quality of individual synthesis at a speed and scale needed for discovery in precision medicine. It also noted that the new pools will enable its customers to use its "high-quality capture technology for smaller projects and in earlier stages where content may still be changing, allowing for a smooth transition to Lockdown Probes as projects are scaled up and validated for clinical use." The firm's xGen Lockdown Probes are already commercially available for target capture in clinical sequencing applications.

Oct 17, 2019

Living DNA Genealogy and Wellbeing Kits

Living DNA has launched two new kits to provide customers with genealogy and wellbeing information. The company's $49 or £49 Starter DNA Kit is designed for individuals who are interested in DNA testing but are unsure about what type of test to take, the company said. Using a mouth swab sample, it provides a high-level global view of a customer's ancestry, the ability to find DNA matches with others worldwide, and wellbeing reports focused on supporting diet and exercise. The company's $129 or £129 Wellbeing Kit, meantime, provides detailed reports including lifestyle-related advice on vitamin levels and deficiencies, metabolism, response to food components such as glucose and lactose, and fitness and exercise response. The new offerings join Living DNA's existing $99/£99 Ancestry Kit.

Oct 17, 2019

Thermo Fisher Scientific Acrometrix BCR-ABL panel

Thermo Fisher Scientific has launched its Acrometrix BCR-ABL Panel. According to Thermo Fisher, the panel is intended to be used as an external control panel for analytical validation of BCR-ABL test methods. The firm said that the research-use-only panel can monitor assay performance at every clinical stage due to its expanded dynamic range.

Oct 16, 2019

iGenomX Riptide High-Throughput Rapid Library Preparation Workflow

iGenomX has launched its Next Generation Genotyping (NGG) application for population-scale research, including its Riptide High-Throughput Rapid Library Preparation (HT-RLP) system. The firm said that NGG allows researchers to analyze more than 10 times the number of genetic variants for a fraction of the cost per sample. Specifically, iGenomX's HT-RLP will allow scientists to perform sequence-based genotyping across more than 37 million genetic markers for less than $80 per sample, including sequencing and analysis. 

Oct 16, 2019

Nonacus ExomeCG Exome Capture Kit

Nonacus of Birmingham, UK, has launched ExomeCG, a "clinically enhanced" exome capture kit that is designed to enable whole-exome sequencing and targeted copy number analysis in a single assay. According to the company's website, the kit provides CNV detection at loci known to have both gene- and exon-level rearrangements, which enables researchers to replace array- and MLPA-based CNV analyses. Codeveloped with bioinformatics firm Congenica, ExomeCG can be used in combination with that company's clinical decision support platform to interpret next-generation sequencing data for clinical decision making, Nonacus said.

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The Los Angeles Times reports that a case of the novel coronavirus making people ill in China has been reported in the US. 

A bipartisan group of senators has introduced a bill seeking increased funding for certain fields, including synthetic biology, ScienceInsider reports. 

Discover magazine writes that paleoproteomics is increasing being used in archaeology, paleoanthropology, and paleontology, including a recent study of a 6,000-year-old ring. 

In Nucleic Acids Research this week: mutagenic effects of ultraviolet "A" light, post-transcription effects of synonymous mutations, and more.