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Oct 15, 2019

Magbio Genomics HighPrep Total RNA Plus Kit

Magbio Genomics has successfully developed the HighPrep Total RNA Plus Kit, a RNA purification chemistry for Mawi DNA Technologies' iSwab-RNA-V2 collection tool. According to Mawi, researchers isolating RNA from iSwab-RNA-v2 using HighPrep will have high-quality RNA yield in the range of 1-4 µg per sample. In addition, Mawi said that both tools can be fully automated on industry platforms including the Hamilton MicroLabStar. 

Oct 15, 2019

Paragon CleanPlex Hereditary Cancer Panel V2

Paragon Genomics has launched its CleanPlex Hereditary Cancer Panel V2. The Haywood, California-based firm said that updated version of the platform halves the number of required primer pools, reducing the required DNA sample size and further increasing ease of use. 

Oct 15, 2019

Qiagen QIAseq FastSelect RNA Removal Products

Qiagen has launched the QIAseq FastSelect -rRNA and -Globin HMR Kits, which are designed to remove more than 97 percent of ribosomal RNA and globin messenger RNA from human, mouse, and rat samples to optimize RNA sequencing.

Qiagen also launched the QIAseq FastSelect 5S/16S/24S Kit to remove abundant bacterial 5S/16S/24S rRNA from RNAseq libraries prepared from complex microbial communities in soil, water, stool, and sludge samples.

The company noted that its QIAseq FastSelect kits remove unwanted RNA with a single 10-second pipetting step and 14 minutes of incubation.

Oct 15, 2019

Loop Genomics Transcriptomics Service

Loop Genomics has launched a targeted, long-read, single-cell transcriptomics service that couples Illumina sequencing instruments with probe capture and cDNA from single cells to generate long-read data. The service includes Loop's computational pipeline that reconstructs the long-read transcripts from clouds of barcoded short reads and provides researchers with actionable reports, the company said.

Oct 14, 2019

PercayAI CompBio

PercayAI, a recently launched spinout of the Genome Technology Access Center at the McDonnell Genome Institute at Washington University School of Medicine in St. Louis, has introduced its first product, CompBio. Featuring augmented intelligence technology, CompBio is meant to help identify relationships within multi-omic datasets to inform drug discovery. The new company said that the software harnesses neural networks, deep learning, and heuristics so that the machine learns from humans as humans learn from the machine. 

Oct 14, 2019

Claret Bioscience SRSLY NGS Library Prep Kit

Claret Bioscience of Santa Cruz, California has launched a directional NGS library preparation kit called SRSLY (Single Reaction Single-stranded LibrarY). SRSLY is a single-stranded approach to library preparation, and can be fine-tuned based on user preference to capture a substantial fraction of short DNA fragments. By foregoing end-polishing, the method also retains the native 5' and 3' ends of each template molecule, providing a precise snapshot of fragmentation products, the company said. The kit's main applications are to help cell-free DNA researchers analyze nucleosome positioning and to aid investigators in producing higher-quality sequencing libraries from degraded DNA sources such as FFPE samples.

Oct 14, 2019

Predictive Laboratories FertilityDX

Predictive Laboratories launched FertilityDX, a genetic testing service that allows physicians to tailor fertility treatments. The test provides information in three areas, the firm said — causes of infertility, risks of pregnancy complications, and risks for serious genetic conditions in the offspring. As part of the service patients are provided pretest counseling, and physicians received an easy-to-understand final report, as well as access to genetic consultants. 

Oct 14, 2019

PerkinElmer PG-Seq Rapid Non-Invasive Preimplantation Genetic Testing Kit

PerkinElmer launched the PG-Seq Rapid Non-Invasive Preimplantation Genetic Testing for Anueploidy kit, which tests spent embryo culture media for chromosomal abnormalities during in vitro treatment. Preimplantation genetic testing for aneuploidiy is used to identify viable embryos and has typically involved a biopsy by creating an opening in the outer coating prior to removal and testing a few cells. Recent studies have demonstrated, however, that an embryo releases small amounts of DNA into the culture media in which it is growing, allowing for the surrounding fluid to be genetically tested. PerkinElmer's kit tests the spent embryo culture to detect aneuploidies and structural rearrangements, including unbalanced translocations and segmental errors.

Oct 11, 2019

Sema4 Expanded Carrier Screening

Sema4 has launched a larger Expanded Carrier Screen for family planning with personalized residual risk.

The test analyzes 502 genes associated with clinically relevant conditions, up from 283 genes, to cover more rare diseases. The test detects more high-risk pregnancies and identifies up to 30 times more carrier couples, Sema4 CEO Eric Schadt said in a statement. It also incorporates low-pass genome analysis to detect ancestry markers that to refine the accuracy of results.

Oct 11, 2019

Dante Labs Whole Genome, Whole GenomeZ Sequencing Service

Dante Labs has launched its Whole Genome and WholeGenomeZ sequencing test services. The firm said that the service — located at its Illumina-backed, Italy-based automated sequencing center — offers reports and raw data for users with a two-week turnaround time. According to Dante Labs, the Premium Whole Genome costs €899 (or $949) for the fastest turnaround time versus €599 (or $649) for the standard turnaround time. The price for the Super Premium Whole GenomeZ is €1,399 (or $1,499) for the fast turnaround time, and €899 (or $999) for the standard turnaround time. 

Oct 10, 2019

Predictive Laboratories ARTguide Test

Salt Lake City, Utah-based Predictive Laboratories has commercially launched its ARTguide DNA-based blood test, which examines the risk for endometriosis and other genetic causes of infertility in women. According to the firm, the test identifies hundreds of genetic markers of endometriosis and 80 other additional mutations causing conditions that may impact fertility.  

Oct 10, 2019

Co-Diagnostics Vector Smart ZDC Test

Co-Diagnostics has commercially launched its Vector Smart ZDC test, which is used to identify the presence of Zika, dengue, and chikungunya in mosquito populations. The firm said that its line of Vector Smart PCR products are validated using extractions from mosquito samples to reduce the possibility of a false negative result due to improper extraction. 

Oct 01, 2019

NanoString nCounter Human Organ Transplant Panel

NanoString Technologies has launched its nCounter Human Organ Transplant panel, a new gene expression panel for evaluating the immune response following organ transplantation. The firm said that it created the assay in collaboration with the Banff Foundation for Allograft Pathology. The panel covers 770 genes and is customizable. It is designed for use with the predominant transplant organs including kidney, heart, lung, and liver. Genes included on the panel are involved in 37 pathways that are components of the immune response, tissue injury, and mechanisms of action for immunosuppressive drugs. The panel also includes probes to detect common viral infections that can cause issues with transplants, including BK polyomavirus, cytomegalovirus, and Epstein-Barr virus.

Oct 01, 2019

Ambry Genetics +RNAinsight

Ambry Genetics has launched +RNAinsight, a combined DNA and RNA genetic test for hereditary cancer syndromes that is designed to return more certain results to patients by using RNA sequencing to definitively classify otherwise ambiguous genetic alterations. While the RNA aspect of the test does not include all known cancer risk genes, it does focus on a subset that includes BRCA1 and 2, TP53, PTEN, and PALB2, among others. Ambry said that the turnaround time for the combined test matches the company's DNA-only hereditary cancer panel.

Oct 01, 2019

ATCC Genome Portal

ATCC has launched its ATCC Genome Portal, a publicly available database of reference-quality genome sequences that are matched to authenticated ATCC biological materials. Integrating low-passaged materials, standardized next-generation sequencing, and a hybrid assembly approach, the tool produces complete reference-quality genomes by combining highly accurate short reads with ultra-long reads. ATCC said that it has launched the portal with an initial 250 genome sequences of widely used bacterial strains.

Sep 30, 2019

T2 Biosystems T2Resistance Panel

The T2 Biosystems T2Resistance Panel for genotypic antibiotic resistance marker testing is now available as a research use only test in the US. The panel uses the firm's T2Dx instrument and identifies 13 genes conferring resistance to common empiric antibiotic therapies, such as carbapenems, vancomycin, and penicillin, directly from whole blood within three to five hours. The panel received breakthrough device designation from the US Food and Drug Administration earlier this year and is on track to receive CE mark by the end of 2019.

Sep 27, 2019

nRichDx: Revolution System

nRichDx has launched its high-yield sample prep Revolution System. The Irvine, California firm designed the in vitro diagnostic system to increase liquid biopsy-based test sensitivity by delivering more target input for molecular assays. Researchers can currently use the platform to extract cell-free DNA from plasma and urine, followed by eventual applications for circulating tumor cells, exosomes, and total cell-free nucleic acid in the development pipeline. 

Sep 27, 2019

Sysmex Inostics SafeSeq Breast Cancer and Head and Neck Panels, SafeSeq Rapid Custom Development Program

Sysmex Inostics has launched its SafeSeq Breast Cancer and Head and Neck Cancer Panels, which both run on the firm's next-generation sequencing SafeSeq platform. The SafeSeq Breast Cancer Panel tests for mutations affecting the PIK3CA, ESR1, TP53, ERBB2, AKT1, and KRAS genes in ER-positive HER2-negative breast cancer samples, the firm noted. The SafeSEQ Breast cancer panel offers sensitive detection of mutant ctDNA, which Sysmex believes is well suited for disease monitoring to assess treatment response, minimal residual disease, and molecular relapse. Sysmex's SafeSeq Head and Neck Cancer panel tests for mutations in the genes PIK3CA, CDKN2A, HRAS, and TP53. 

In addition to the cancer panels, Sysmex now offers its SafeSeq Rapid Custom Development program for circulating tumor DNA (ctDNA) analysis. The firm said that users can assemble targeted genes and mutations into highly sensitive fit-for-purpose assays with customer-selected levels of analytical and clinical validation.

Sep 26, 2019

Almac Diagnostics Services ClaraT Total mRNA Report

Almac Diagnostic Services of Craigavon, Northern Ireland, is launching the complete version of its ClaraT Total mRNA Report at the European Society for Medical Oncology meeting in Barcelona this weekend. The report content has expanded from an initial version launched a year ago, Almac said, and now includes 92 gene expression signatures, 100 single-gene drug targets, and more than 7,000 additional biology-linked genes categorized by 10 hallmarks of cancer. The research-use-only product uses RNA sequencing alongside proprietary bioinformatics to provide investigators with an interactive report that facilitates visualization of novel molecular subgroups within a sample cohort and key discriminating biology in individual tumor samples, the company said.

Sep 25, 2019

Fluidigm Cadmium Metal Labeling Kits for Mass Cytometry

Fluidigm has releases seven new Maxpar cadmium metal labeling kits for use with mass cytometry: 106Cd, 110Cd, 111Cd, 112Cd, 113Cd, and 116Cd. Fluidigm said that the kits will enable researchers to easily expand mass cytometry panels as demand grows for larger panels to interrogate the immunome, cancer, and other complex diseases. When the labels are used with existing panels comprising more than 20 parameters, researchers can simultaneously profile more than 50 cell surface and intracellular parameters in a single run. Researchers can also use the kits to customize Fluidigm pre-designed panels, including the Maxpar Direct Immune Profiling Assay, Fluidigm said.

Sep 25, 2019

Roche Cobas EBV, BKV Tests

Roche has launched the Cobas EBV and BKV tests for Epstein-Barr virus and BK virus in countries accepting the CE mark. The tests are for use with Roche's Cobas 6800/8800 Systems. The real-time PCR tests leverages dual target technology help clinicians manage the risk of infection for severely immunocompromised transplant patients and assess if these patients are at risk of of developing disease, which can contribute to organ rejection, the company said. 

Sep 23, 2019

Era7 V4V6 Taxonomic Profiling Service

Spanish-based Era7 has launched its V4V6 taxonomic profiling service for amplicon analysis. According to the firm, the approach uses optimal primers located in 16S regions highly conserved in bacteria and archaea. Using 300-cycle Illumina reagents, the approach sequences V4 and V6 variable regions and their flanking sequences. Era7 said that it has designed the primers to cover all sequences included in its 16SDB7 database. 

Sep 23, 2019

Streck: RNA Complete BCT

Streck has commercially launched its RNA Complete Blood Collection Tube (BCT). According to the firm, the tool maintains draw time cell-free RNA concentration while limiting the release of extracellular vesicles from blood cells. The BCT maintains the targets for up to seven days at room temperature. 

Sep 20, 2019

Toyobo RNA Analysis Kit

Toyobo of Japan is releasing RNA Analysis Kit for full-length sequencing of total RNA from a single cell. The kit is based on a method called RamDA-seq that was developed by researchers at the Laboratory for Bioinformatics Research at the Riken Center for Biosystems Dynamics Research in Japan. The method enables RNA amplification with low bias and the comprehensive identification of RNA varieties and their amounts in a single cell. The kit will officially be launched on Sept. 30.

Sep 18, 2019

Yourgene Elucigene DPYD

UK-based Yourgene has launched the Elucigene DPYD assay, a CE-marked chemotoxicity diagnostic test that uses genotyping to identify cancer patients with dihydropyrimidine dehydrogenase (DPD) deficiency. The deficiency causes several and sometimes lethal side effects in patients treated with 5-fluorouracil (5-FU), which is metabolized by the DPD enzyme, encoded by the DPYD gene. Elucigene DPYD, which tests for six common genetic variations, conforms with Clinical Pharmacogenetics Consortium guidelines, which recommend testing for four clinically relevant mutations.

Pages

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