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Oct 01, 2019

ATCC Genome Portal

ATCC has launched its ATCC Genome Portal, a publicly available database of reference-quality genome sequences that are matched to authenticated ATCC biological materials. Integrating low-passaged materials, standardized next-generation sequencing, and a hybrid assembly approach, the tool produces complete reference-quality genomes by combining highly accurate short reads with ultra-long reads. ATCC said that it has launched the portal with an initial 250 genome sequences of widely used bacterial strains.

Sep 30, 2019

T2 Biosystems T2Resistance Panel

The T2 Biosystems T2Resistance Panel for genotypic antibiotic resistance marker testing is now available as a research use only test in the US. The panel uses the firm's T2Dx instrument and identifies 13 genes conferring resistance to common empiric antibiotic therapies, such as carbapenems, vancomycin, and penicillin, directly from whole blood within three to five hours. The panel received breakthrough device designation from the US Food and Drug Administration earlier this year and is on track to receive CE mark by the end of 2019.

Sep 27, 2019

nRichDx: Revolution System

nRichDx has launched its high-yield sample prep Revolution System. The Irvine, California firm designed the in vitro diagnostic system to increase liquid biopsy-based test sensitivity by delivering more target input for molecular assays. Researchers can currently use the platform to extract cell-free DNA from plasma and urine, followed by eventual applications for circulating tumor cells, exosomes, and total cell-free nucleic acid in the development pipeline. 

Sep 27, 2019

Sysmex Inostics SafeSeq Breast Cancer and Head and Neck Panels, SafeSeq Rapid Custom Development Program

Sysmex Inostics has launched its SafeSeq Breast Cancer and Head and Neck Cancer Panels, which both run on the firm's next-generation sequencing SafeSeq platform. The SafeSeq Breast Cancer Panel tests for mutations affecting the PIK3CA, ESR1, TP53, ERBB2, AKT1, and KRAS genes in ER-positive HER2-negative breast cancer samples, the firm noted. The SafeSEQ Breast cancer panel offers sensitive detection of mutant ctDNA, which Sysmex believes is well suited for disease monitoring to assess treatment response, minimal residual disease, and molecular relapse. Sysmex's SafeSeq Head and Neck Cancer panel tests for mutations in the genes PIK3CA, CDKN2A, HRAS, and TP53. 

In addition to the cancer panels, Sysmex now offers its SafeSeq Rapid Custom Development program for circulating tumor DNA (ctDNA) analysis. The firm said that users can assemble targeted genes and mutations into highly sensitive fit-for-purpose assays with customer-selected levels of analytical and clinical validation.

Sep 26, 2019

Almac Diagnostics Services ClaraT Total mRNA Report

Almac Diagnostic Services of Craigavon, Northern Ireland, is launching the complete version of its ClaraT Total mRNA Report at the European Society for Medical Oncology meeting in Barcelona this weekend. The report content has expanded from an initial version launched a year ago, Almac said, and now includes 92 gene expression signatures, 100 single-gene drug targets, and more than 7,000 additional biology-linked genes categorized by 10 hallmarks of cancer. The research-use-only product uses RNA sequencing alongside proprietary bioinformatics to provide investigators with an interactive report that facilitates visualization of novel molecular subgroups within a sample cohort and key discriminating biology in individual tumor samples, the company said.

Sep 25, 2019

Fluidigm Cadmium Metal Labeling Kits for Mass Cytometry

Fluidigm has releases seven new Maxpar cadmium metal labeling kits for use with mass cytometry: 106Cd, 110Cd, 111Cd, 112Cd, 113Cd, and 116Cd. Fluidigm said that the kits will enable researchers to easily expand mass cytometry panels as demand grows for larger panels to interrogate the immunome, cancer, and other complex diseases. When the labels are used with existing panels comprising more than 20 parameters, researchers can simultaneously profile more than 50 cell surface and intracellular parameters in a single run. Researchers can also use the kits to customize Fluidigm pre-designed panels, including the Maxpar Direct Immune Profiling Assay, Fluidigm said.

Sep 25, 2019

Roche Cobas EBV, BKV Tests

Roche has launched the Cobas EBV and BKV tests for Epstein-Barr virus and BK virus in countries accepting the CE mark. The tests are for use with Roche's Cobas 6800/8800 Systems. The real-time PCR tests leverages dual target technology help clinicians manage the risk of infection for severely immunocompromised transplant patients and assess if these patients are at risk of of developing disease, which can contribute to organ rejection, the company said. 

Sep 23, 2019

Era7 V4V6 Taxonomic Profiling Service

Spanish-based Era7 has launched its V4V6 taxonomic profiling service for amplicon analysis. According to the firm, the approach uses optimal primers located in 16S regions highly conserved in bacteria and archaea. Using 300-cycle Illumina reagents, the approach sequences V4 and V6 variable regions and their flanking sequences. Era7 said that it has designed the primers to cover all sequences included in its 16SDB7 database. 

Sep 23, 2019

Streck: RNA Complete BCT

Streck has commercially launched its RNA Complete Blood Collection Tube (BCT). According to the firm, the tool maintains draw time cell-free RNA concentration while limiting the release of extracellular vesicles from blood cells. The BCT maintains the targets for up to seven days at room temperature. 

Sep 20, 2019

Toyobo RNA Analysis Kit

Toyobo of Japan is releasing RNA Analysis Kit for full-length sequencing of total RNA from a single cell. The kit is based on a method called RamDA-seq that was developed by researchers at the Laboratory for Bioinformatics Research at the Riken Center for Biosystems Dynamics Research in Japan. The method enables RNA amplification with low bias and the comprehensive identification of RNA varieties and their amounts in a single cell. The kit will officially be launched on Sept. 30.

Sep 18, 2019

Yourgene Elucigene DPYD

UK-based Yourgene has launched the Elucigene DPYD assay, a CE-marked chemotoxicity diagnostic test that uses genotyping to identify cancer patients with dihydropyrimidine dehydrogenase (DPD) deficiency. The deficiency causes several and sometimes lethal side effects in patients treated with 5-fluorouracil (5-FU), which is metabolized by the DPD enzyme, encoded by the DPYD gene. Elucigene DPYD, which tests for six common genetic variations, conforms with Clinical Pharmacogenetics Consortium guidelines, which recommend testing for four clinically relevant mutations.

Sep 17, 2019

Biognosys Spectronaut 13.7

Biognosys of Switzerland has released a new version of its Spectronaut 13 mass spectrometry analysis software. The update, version 13.7, includes beta support for the parallel accumulation-serial fragmentation (PASEF) and diaPASEF methods, which are available on Bruker's timsTOF Pro instrument.

Sep 12, 2019

Euformatics OmnomicsQ Ion Torrent Suite Plugin

Euformatics has launched the OmnomicsQ Ion Torrent Suite plugin. The software can be fully integrated with Thermo Fisher Scientific Ion Torrent sequencers to enable users to access quality control metrics and graphics as part of their workflows without the need for manual external program integration. The plugin gives Ion Torrent Suite users quality information for every sample run as part of their standard run procedure, helping to eliminate errors and flagging any issues with data quality before it affects patients, Helsinki-based Euformatics noted. In addition, the plugin enables users to perform clinical test validation of their next-generation sequencing pipelines with the OmnomicsV validation and verification software.

Sep 09, 2019

Sphere Fluidics Cyto-Cellect Human IgGk Detection Kit

Sphere Fluidics has launched its Cyto-Cellect Human IgGk Detection Kit to measure antibody class and productivity for cell line development. The FRET-based assay detects the presence of human IgG from encapsulated cells in picodroplets with kappa light chain after secretion, characterizing and measuring antibody production. According to the firm, users can combine the kit with with the Cyto-Mine Single Cell Analysis System.  

Sep 09, 2019

Fluidigm Advanta RNA-Seq NGS Library Prep Kit

Fluidigm has launched its Advanta RNA-Seq NGS Library Prep Kit, which runs on the firm's Juno microfluidic system. According to the firm, the next-generation sequencing kit allows researchers to reduce their costs for full-length stranded libraries by up to 50 percent. Fluidigm noted that the automated workflow can also reduce the number of operator interventions and total hands-on time to about two hours. The kit allows researchers to simultaneously process up to 48 samples using a integrated microfluidic circuit (IFC). By integrating solid-phase sample enrichment with sequential enzymatic reaction on the IFC, the workflow automates multiple reaction steps to product up to 48 libraries for sequencing on Illumina systems. 

Sep 06, 2019

Fluidigm Maxpar Imaging Mass Cytometry Kits; CyTOF Software

Fluidigm this week launched three new imaging mass cytometry kits and new CyTOF software at the 2019 World Molecular Imaging Congress.

Fluidigm's Maxpar Human Immuno-Oncology Panel Kits are designed for immune-oncology research. Developed using pathologist-verified antibodies, the panels can be mixed and matched to profile tumor-infiltrating lymphocytes, immune cell activation states, and tissue architecture. By combining them as a single 18-marker panel, researchers can broadly profile activated tumor-infiltrating lymphocytes for single-cell analysis of tumor architecture from a single tissue scan, Fluidigm said.

Fluidigm's CyTOF software, meantime, is designed to be used with the Hyperion Imaging System for cellular biomarker identification. According to the firm, the software streamlines the selection and acquisition of multiple regions of interest (ROI) from each slide. Researchers can remotely annotate those ROIs using brightfield reference images to guide automated batch acquisition of highly multiplexed images at 1-micron resolution. During image acquisition, researchers can visualize multiplexed images in real time across all detection channels to ensure data quality, Fluidigm said.

Sep 05, 2019

Swift Biosciences RNA Library Kits

Swift Biosciences has launched its RNA Library Kits. With patented Adaptase technology, the kits allow direct conversion of first-strand complementary DNA, reverse transcribed from RNA, into libraries for Illumina sequencing.

The firm is offering two kits: the Swift RNA Library Kit, which supports a broad input range from as little as 10 nanograms of total RNA or 100 picograms of poly(A)-enriched messenger RNA or ribosomal RNA-depleted RNA, and the Swift Rapid RNA Library Kit, which is faster and lower-priced. Both kits are available in 24- or 96-reaction kits.

The products include an RNA fragmentation module, a reverse transcription module, library prep reagents, polymerase, and several indexing primer kit options for single, combinatorial, and unique dual indexing.

Sep 04, 2019

Xifin LIS 6

Xifin has introduced a new version of its laboratory information system, Xifin LIS 6. The latest iteration of the software-as-a-service platform includes several features resulting from recently formed partnerships. Notably, Xifin LIS 6 includes artificial intellegence-driven genomic data interpretation, thanks to a partnership with Fabric Genomics. The new release supports fast, scaleable analysis of next-generation sequencing to produce "physician-ready" clinical reports, the company said.  

Other upgrades in LIS 6 include support for digital pathology workflows via a collaboration with Proscia, integration of Glidian's automated prior authorization technology, and access to test utilization support from the Medical Database LDS laborator decsion system.

Aug 16, 2019

Integrated DNA Technologies oPools Oligo Pools

Integrated DNA Technologies has launched its oPools Oligo Pools, ready-to-use pools of high-quality DNA oligonucleotides. According to the Coralville, Iowa-based firm, the pools contain customized, single-stranded DNA sequences between 40 and 350 nucleotides in length. Because the pools are delivered in picomoles, researchers do not need to perform any pre-amplification or other pre-work before using the pool. IDT said that oPools' low error rate of less than 1 in 2,000 nucleotides, coupled with high per-oligo yields, allow researchers to immediately proceed into their downstream workflows including CRIPSR library construction, protein screening, and gene assembly.   

Aug 15, 2019

Loop Genomics LoopSeq Bacterial Genome Sequencing Kit and Services

Loop Genomics has launched a new sample preparation kit and service for de novo bacterial genome assembly using synthetic long reads on Illumina sequencers.

The LoopSeq Bacterial Genome Sequencing kit leverages the firm's chemistry and computational pipeline to create reads thousands of base pairs long, providing high-quality assemblies with fewer total contigs, higher N50 values, and fewer misassemblies.

San Jose, California-based Loop Genomics said the kit is plug-and-play and can easily replace existing sample preparation kits for bacterial genome sequencing experiments, using Loop's software for data analysis.

Aug 13, 2019

Dovetail Genomics Omni-C Assay

Dovetail Genomics has launched the Omni-C, a new assay based on the Hi-C method for chromosome conformation capture.

Scotts Valley, California-based Dovetail said it designed the assay for ease of use and improved reproducibility. The firm claims the assay offers better coverage compared to standard Hi-C approaches, by using an endonuclease, rather than restriction enzymes, to digest cross-linked chromatin.

Traditional restriction enzyme-based Hi-C approaches generate data only near the restriction enzyme sites, resulting in gaps of information. By using an endonuclease, Omni-C enables coverage of a significant portion of the genome that does not contain these restriction sites, estimated to be around 20 percent in human genomes. 

Applications for Omni-C include structural genetic variant detection and generating genome assemblies. 

Aug 09, 2019

Streck ARM-D Kits; RNA Complete BCT

Streck this week launched three new real-time PCR antibiotic resistance kits for research use only. The kits cover MCR, expanded OXA, and TEM/SHV/GES to detect variants of resistance genes considered by the US Centers for Disease Control.

Streck also introduced RNA Complete BCT, a direct-draw whole-blood collection tube containing a specially designed reagent which maintains the draw-time concentration of extracellular vesicles such as exosomes for up to 7 days at room temperature storage.

Aug 08, 2019

Novogene NovoPM 2.0 Cancer Panel

Chula Vista, California-based Novogene has launched its NovoPM 2.0 Cancer Panel, a next-generation sequencing panel that analyzes 484 solid tumor-related genes and introns in 43 genes. According to the firm, the test can detect four types of genomic abnormalities (single nucleotide variation, insertions/deletions, copy number variation, and fusions), and features bioinformatics software including three algorithms specific for guiding cancer immunotherapy decision making.

Aug 08, 2019

ChunLab TrueBac ID

Korean bioinformatics firm ChunLab has launched TrueBac ID, a cloud-based platform that combines proprietary algorithms and a manually curated reference database for bacterial identification targeting more than 12,000 species. The system can provide a full identification report within 30 minutes after a user uploads a genome assembly or raw shotgun sequencing data as a FASTQ file. The report provides fully resolved taxonomic classification, antimicrobial resistance genes, and virulence genes to facilitate correct diagnosis and appropriate therapy. In a recently published study, TrueBac ID was able to accurately identify 34 of 36 clinical isolates (94.4 percent) that were not identified using three commercially available MALDI-TOF MS systems. ChunLab said that it is providing the service for free to all users until the end of 2019 with certain restrictions. In 2020, the company plans to add functions such as strain typing to the platform.

Aug 02, 2019

Twist Bioscience Long Oligonucleotides

San Francisco-based Twist Bioscience has launched its long oligonucleotides product line. According to the firm, the synthetic nucleotides can be upto 300 bases and will increase the success and productivity of biological research. While adding bases normally introduces the risk of error, Twist said it has developed a proprietary way to make oligos with an error rate as low as 1:1500 nucleotides.

Pages

New research shows that scientists need to do a better job of including a wider diversity of African genomes in their analyses, STAT says.

A new paper in Science shows that men are still winning a large majority of the most sought-after NIH grants.

Nature Research and the Estée Lauder Companies are awarding efforts to encourage girls to pursue careers in the STEM fields.

In Science this week: beneficial genetic variants inherited from archaic Neanderthal and Denisovan hominins, and more.