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May 29, 2019

Fluidigm Advanta Solid Tumor NGS Library Prep Assay

Fluidigm has launched the Advanta Solid Tumor NGS Library Prep Assay for the simultaneous detection of somatic variants across 53 solid tumor genes using a microfluidic library prep workflow. The assay was developed for use with the company's Juno system which automates the target enrichment of single-nucleotide variations, indels, and copy number variations for subsequent analysis on Illumina sequencing platforms. The assay comes with a new Juno LP 8.8.6 microfluidic cartridge that enables users to easily process up to six different panels simultaneously with 10-fold lower sample input. Users can also add new cancer markers to the Advanta panel using Fluidigm D3 assay design services, the company said.

May 24, 2019

PreOmics PreON

PreOmics has launched its PreON protein sample preparation platform. According to the company's website, PreON processes 4 to 12 samples in less than three hours and uses a plug-and-play method selection that streamlines protein sample processing for mass spectrometry-based protein analysis. The benchtop system also features an onboard heated shaker, automated swing-out centrifuge, and automated pipetting, and is designed to eliminate both manual processing steps and errors.

May 23, 2019

Philip Morris International GladiaTox

Philip Morris International (PMI) has launched GladiaTox, an open-source informatics product for high-content screening data in biomedical research. According to PMI, GladiaTox allows "robust and efficient storage, processing, and reporting of HCS data, in line with the landmark 21st Century Toxicology program." The firm's platform is an evolution of the ToxCast Pipeline created for the US Environmental Protection Agency. The solution can analyze disparate types of HCS data in an integrated fashion and supports the "3S" approach to biological understanding – "systematic, systemic, and systems," which looks at organisms in their entirety rather than specific organs in isolation. PMI developed GladiaTox in collaboration with Filer Consulting.

May 23, 2019

MGI Single-Cell RNA Sequencing Solution

BGI subsidiary MGI has begun marketing a product solution that allows users of BGI and MGI sequencing platforms to perform single-cell RNA sequencing (scRNA-seq) with 10x Genomics' technology. The solution includes the MGIEasy Universal Library Conversion Kit, a new product, as well as the 10x Genomics Chromium Controller and Single-Cell RNA Solutions. Researchers from the UK and Australia recently tested BGI's sequencing technology for scRNA-seq with 10x Genomics' platform.

May 17, 2019

New England Biolabs Monarch Genomic DNA Purification Kit

New England Biolabs has launched the Monarch Genomic DNA Purification Kit for high-yield purification of high-molecular-weight DNA fragments (peak size greater than 50 kb), making it ideal for use upstream of long-read sequencing platforms. The inclusion of RNase A, optimized protocols, and buffer chemistry enable researchers to prevent RNA contamination (RNA levels are generally less than 1 percent) and address a wide variety of sample types without having to purchase any specialized kits, NEB said.

May 14, 2019

Primerdesign Genesig q32

Primerdesign, the molecular business of Novacyt, has launched a next-generation molecular testing instrument called Genesig q32. The new qPCR instrument is larger than the firm's Genesig q16 instrument and provides customers with a faster, higher throughput solution for using Novacyt's genesig real-time PCR kits. The q32 provides test results within 60 minutes using Genesig kits, processing up to 32 patient samples in tube or strip format with fluorescence detection technologies.

May 10, 2019

IDT Custom NGS Adapters, Lotus DNA Library Prep Kit

Integrated DNA Technologies has launched custom NGS adapters, which customers can order in three configurations using the company's Custom Adapter Configuration online ecommerce tool: TruSeq-compatible full-length adapters, TruSeq-compatible stubby adapters and indexing primers, and Nextera-compatible indexing primers.

In addition, IDT has released the Lotus DNA Library Prep kit, an enzymatic library preparation solution for whole-genome sequencing and hybridization capture applications. The kit is optimized for use with IDT's custom adapters and xGen capture products and has a 2-hour workflow. It is compatible with TA-ligation adaptors and can be tailored to different applications when combined with the new adapters.

May 06, 2019

The Sequencing Center Human WGS Service

The Sequencing Center of Fort Collins, Colorado has launched a human whole-genome sequencing service for medical research. It includes data analysis as well as data management services. Customers can also request DNA extraction to be performed at no additional cost. According to the firm's website, sequencing projects take 10 to 15 business days to complete.

May 01, 2019

Arc Bio Galileo Pathogen Solution, GPS-Transplant

Arc Bio has launched the Galileo Pathogen Solution product line and first product, GPS-Transplant, a research-use-only next-generation sequencing test to aid in monitoring post-transplant patients for viral infections. GPS-Transplant detects the most common viral infections among transplant patients, including cytomegalovirus, Epstein–Barr virus, BK virus, and human adenovirus. The test also detects different variances and genotypes of the viruses, as well as more rare infections. GPS-Transplant also offers the ability to detect antiviral resistance mutations, and performs simultaneous quantitative detection of more than 350 viral strains. It is a sample-to-report solution built around the Illumina NGS platform that consists of reagents, built-in assay controls, and Galileo Analytics, a cloud-based proprietary software that provides quick and reliable results, an intuitive user interface, and detailed, actionable reports. The analytics software leverages Arc Bio's curated pathogen database called ArcIve, and also incorporates AMR resistance prediction technology which Arc Bio launched last year.

Apr 30, 2019

Thermo Fisher Scientific MagMax Nucleic Acid Isolation Kits

Thermo Fisher Scientific has launched several new MagMax nucleic acid isolation kits. The kits, which uses MagMax magnetic bead technology, are optimized for Thermo Fisher KingFisher Flex and Duo Prime instruments. The MagMax Microbiome Ultra Nucleic Acid Isolation Kit is designed to isolate RNA and DNA from microbiome samples such as stool and soil samples; the MagMax Viral/Pathogen Ultra Nucleic Acid Isolation Kit is made for recovering RNA and DNA from difficult-to-lyse microorganisms, including gram-positive bacteria, yeast, and fungi; and the MagMax Viral/Pathogen Nucleic Acid Isolation Kit is for isolating RNA and DNA from viral particles and gram-negative bacteria found in samples such as blood, swabs, urine, and viral transport media.

Apr 30, 2019

New England Biolabs NEBNext Enzymatic Methyl-seq

New England Biolabs has launched NEBNext Enzymatic Methyl-seq (EM-seq), an enzyme-based method for methylation sequencing that is an alternative to bisulfite sequencing. The EM-seq kit involves a two-step enzymatic conversion that first protects 5-methyl cytosine and 5-hydroxymethyl cytosine from deamination using TET2 and an oxidation enhancer, and then deaminates unmethylated cytosines, converting them to uracil. Because the process does not rely on chemical treatment, as with bisulfite conversion, the DNA is not damaged, according to the company. The kit includes the required reagents for EM-seq conversion and library preparation for sequencing on Illumina instruments.

Apr 24, 2019

Human Diagnostics Worldwide, Eiken Chemical, FIND Malaria-LAMP

Human Diagnostics Worldwide, Eiken Chemical, and the Foundation for Innovative New Diagnostics launched Malaria-LAMP for the detection of malaria caused by Plasmodium vivax parasites. The group said that it is the first commercially available molecular test for P. vivax-associated malaria. The assay uses loop-mediated isothermal amplification developed by Eiken and is exclusively distributed by Human Diagnostics. FIND and the Hospital for Tropical Diseases evaluated the prototype test and coordinated in-country clinical performance studies in Columbia and Peru. The test can differentiate between Plasmodium pan species, P. falciparum, and P. vivax, and has a sensitivity of 84 percent to 94 percent and a specificity of greater than 92 percent. According to the group, the assay's limit of detection is one to two parasites per microliter.

Apr 24, 2019

Pacific Biosciences Sequel II System

Pacific Biosciences has launched it Sequel II single-molecule sequencing instrument. The new system runs SMRT chips that contain 8 million wells, or zero-mode waveguides (ZMWs). The system delivers around eight times greater data output than the firm's original Sequel instrument, which had 1 million ZMWs. According to the company, its HiFi reads, which make use of PacBio's circular consensus sequencing (CCS) protocol, have greater than 99.9 percent accuracy. As of last month, five early access customers had run 58 SMRT cells, obtaining average yields per SMRT cell for the CCS protocol of 250.4 gigabases and average per-cell yields for its continuous long read protocol of 67.4 gigabases.

Apr 23, 2019

Cell Microsystems AIR Software Update, HexaQuad Array

Cell Microsystems has released new software for its AIR system, which automates cloning workflows using brightfield imaging to eliminate the need for fluorescent markers for sorting and confluency measurement. In addition, another new feature automates cell-sorting based on fluorescent signal intensities to characterize complex phenotypes.

Cell Microsystems has also launched the HexaQuad array, which it has designed to simultaneously run 24 distinct experiments on a single consumable. The firm said that the array is suited for labs who perform high-throughput CRISPR editing in single guide or guide pools, which allows for scaling of hundreds of clones per week and reducing a two-month workflow. Combined with the new software, the array provides a five-day workflow for researchers.

Apr 22, 2019

MycoDART MycoDART-PCR

MycoDART has launched MycoDART-PCR, a dual amplification real-time PCR DNA test for the rapid detection of Candida aurus. Pending approval by the US Food and Drug Administration, the test can be ordered currently only through RealTime Laboratories and only with a doctor's order. The launch comes amid reports that C. auris, which is highly resistant to antifungal medications, is spreading throughout the US. C. auris is 1 of 6 Candida species that MycoDART-PCR can detect. It offers a specificity and sensitivity of 95 percent and has been validated for blood, body fluids, and tissue MycoDART said. It can also be run to detect for the presence of C. auris on environmental sufraces. For such purposes, a doctor's order is not needed for the test. 

Apr 18, 2019

Altos, Wasai Accelerated Genome Sequencing Solution

Acer subsidiary Altos Computing and WASAI Technology have globally launched an accelerated sequencing genome solution that will focus on human genome sequencing. The group said the development will integrate Altos' BrainSphere AI computing platform with WASAI's software to create a tool that is faster for genome sequencing without sacrificing accuracy. The joint solution will allow researchers to complete germline analyiss within eight hours. According to the firms, the tool will also help facilities accelerate native algorithms for resutls that are as precise and consistent as the original software. 

Apr 15, 2019

Thermo Fisher Scientific Applied Biosystems QuantStudio 6 and 7 Pro Real-Time PCR Systems

Thermo Fisher Scientific has launched the Applied Biosystems QuantStudio 6 and 7 Pro Real-Time PCR systems. They include smart features such as facial authentication, voice commands, radio-frequency identification (RFID)-enabled plate scanning, and single-touch access to service and support.

Apr 12, 2019

Ares Genetics AresUPA NGS Service

Curetis subsidiary Ares Genetics announced today that it will launch a next-generation sequencing service in mid-2019 using its AresUPA Universal Pathogenome Assay, which can be used to sequence bacterial strains isolated from clinical specimens. According to the firm, AresUPA identifies the bacterial strain and detects antimicrobial resistance based on the genetic profile in the clinical isolate. The assay integrates NGS with data analysis and interpretation powered by ARESdb, the firm's AI-powered reference database on antimicrobial resistance genetics. Ares will offer the assay out of its NGS service laboratory currently being set up in Vienna, Austria. 

Apr 12, 2019

Centogene CentoMetabolic Panel

Centogene has launched its CentoMetabolic panel, a first-line test for a range of rare genetic metabolic diseases. According to Centogene, the panel combines genetic and biochemical testing, allowing immediate confirmation of and better understanding of a disease's course, enhanced treatment monitoring, and tailored treatment guidance. The panel includes as many as 166 genes and was developed for patients suspected to have a metabolic disorder or presenting complex, overlapping symptoms, a metabolic crisis, or neurological conditions of unknown etiology. The firm said that the panel provides short turnaround times, targets critically ill patients, includes enzyme-activity testing and a continually updating set of biomarkers. 

Apr 11, 2019

PetaSuite Protect

PetaGene has introduced PetaSuite Protect, an encryption and access-management system for genomic data. The new product system features Advanced Encryption Standard 256-bit (AES-256) encryption and is compliant with the Federal Information Processing Standard (FIPS) Publication 140-2, a security standard used by the US government. PetaSuite Protect also offers data managers the ability to grant access to specific regions of genomic data files, rather than opening up whole files to all users.

Apr 11, 2019

Enpicom ImmunoGenomiX

Enpicom has introduced ImmunoGenomiX, an immune sequencing data analysis platform. Known as IGX, the platform will help researchers manage, store, analyze, visualize, and interpret immune repertoire sequencing data from T-cell and B-cell receptors. The Netherlands-based company unveiled IGX at the Sixth Immunotherapy of Cancer Conference in Vienna, Austria. 

Apr 09, 2019

Quantabio Qscript lyo 1-step

Quantabio has launched its Qscript lyo 1-step, a lyophilized single-reaction reagent for highly sensitive and reproducible RT-qPCR RNA applications. The firm said that the freeze-dried master mix can be shipped and stored at ambient temperature, which removes the need for cold chain, cuts the carbon footprint, reduces overall costs. Users can store the master mix up to nine months at ambient temperature, or two years at 4 degrees Celsius from the manufacture date. According to the firm, Qscript allows researchers to routinely detect down to 0.5 picograms of RNA. The kit contains a hot-start thermostable polymerase, a genetically engineered reverse transcriptase, as well as other components that the firm said will ensure higher performance detection while multiplexing up to five targets with maximum sensitivity and specificity. The reagent offers high-performance across a range of inputs from 0.5-500 picograms. 

Apr 05, 2019

Fabric Genomics Hereditary Panels With ACE

Fabric Genomics has launched Fabric Hereditary Panels with ACE (AI Classification Engine) software for variant interpretation and clinical reporting. ACE is an artificial intelligence inference engine that leverages deep gene and variant annotation, resulting in highly accurate American College of Medical Genetics variant classification. The software is embedded within the Fabric Enterprise platform for genomic analysis and reporting that delivers a complete sequence-to-clinical report workflow. ACE enhances the Fabric Enterprise platform, making ACMG classification even faster and easier, the company said. The new software is now available for many common genetic tests such as inherited cancer risk including BRCA1 and BRCA2, newborn screening, and CDC-Tier 1 and ACMG incidental findings testing.

Apr 04, 2019

Emedgene Automated Evidence Retrieval

Emedgene has added automated evidence retrieval to its genetic interpretation platform. The new feature relies on natural-language processing to extract knowledge and medical evidence from unstructured text in medical literature. By combining NLP with machine learning, the Emedgene platform can provide actionable insights instead of just search results, the company said.

Apr 02, 2019

Progenity Resura Prenatal Test for Monogenic Disease; Innatal Prenatal Screen

Progenity has launched the Resura prenatal test for monogenic disease, a customizable, noninvasive prenatal test (NIPT) for single-gene disorders. The test is available to families with known risk for monogenic disease such as cystic fibrosis, sickle cell anemia, and Tay-Sachs disease. The test, which was developed using droplet digital PCR, uses fetal cell-free DNA extracted from a sample of the mother's blood, and can be performed on disease-causing variants of all inheritance types, including recessive, dominant, and X-linked genetic mutations.

Progenity also announced improvements to its Innatal prenatal screen, a NIPT for chromosomal aneuploidies that now provides greater specificity and sensitivity in evaluating aneuploidy across all chromosomes. Specifically, the sequencing-based test has been enhanced in terms of detecting aneuploidies in chromosomes 21, 18, 13, X, and Y, the company said.

Pages

New US Department of Commerce rules will affect supercomputing in China, according to the Wall Street Journal.

A new analysis finds that it will be more than a century until female computer scientists publish at the same rate as their male counterparts, ScienceInsider reports.

Broad Institute researchers describe an approach they've dubbed "DNA microscopy."

In PLOS this week: epigenetic changes following hepatitis C virus treatment, metagenomic analysis of Ugandan children with febrile illness, and more.