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Dec 10, 2019

Fluidigm Maxpar Antibodies

Fluidigm has released more than 100 pathologist-verified Maxpar antibodies for use with imaging mass cytometry on the Hyperion Imaging System. The company's portfolio now includes antibodies verified for use with both formalin-fixed, paraffin-embedded and frozen tissues. Imaging mass cytometry provides visualization of complex cellular phenotypes and their relationships in the context of cancer, immuno-oncology, and immune-mediated diseases. Using the dual capability of the Hyperion Imaging System, researchers can deeply profile a wide range of samples from blood to tissues using both mass cytometry and imaging mass cytometry, Fluidigm said.

Dec 10, 2019

Bionano Genomics: Prep SP Bone Marrow Aspirate Kit

Bionano Genomics has launched a new kit for DNA isolation from bone marrow aspirates.

The Bionano Prep SP Bone Marrow Aspirate Kit allows for the consistent isolation of ultra high molecular weight DNA in four hours. Bone marrow aspirates, the primary sample type collected from leukemia patients, are traditionally considered a more complex sample type, due to cell clumps and other insoluble impurities.

Dec 10, 2019

GenScript Precision Mutant Library Services

GenScript has launched Precision Mutant Library Services for the drug development, industrial chemical, and synthetic biology markets. The new service utilizes GenScript's proprietary semiconductor oligo synthesis technology to deliver precise control over each synthesized variant. The result is a more diverse and fully covered mutant library with unbiased distribution.

The Precision Mutant Library Services include site-saturation mutagenesis, saturation scanning mutagenesis, or combinatorial mutagenesis libraries. Saturation mutagenesis libraries provide the ability to screen mutations located at several sites within a protein sequence or across the total sequence space. Each position is mutated to all 19 non-wild-type amino acids. Combinatorial mutagenesis libraries involve mutating multiple positions simultaneously across specific target regions of a protein and exploring all possible combinations of mutations.

Dec 10, 2019

Horizon Discovery Predesigned Synthetic sgRNAs

Horizon Discovery is now offering predesigned synthetic single guide RNA (sgRNA). The sgRNAs are available individually or as library collections, and are being offered as an expansion to the company's Edit-R gene engineering platform. Using synthetic sgRNAs enables researchers to achieve reliable gene knockouts, even in complex, difficult-to-edit cell types and experimental models, Horizon said. The synthetic sgRNAs have been designed to maximize the likelihood of functionally knocking out the gene or genes of interest while minimizing off-target effects.

When paired with Cas9 mRNA or Cas9 protein, the sgRNAs also allow researchers to perform DNA-free gene editing in a new one-part format, streamlining their gene editing workflows without the potential for nuclease or guide integration into the cell's genome. They can also be paired with expressed formats such as Cas9 integrated cell lines.

Dec 05, 2019

InterVenn Biosciences OpenPIP Mass Spectrometry Analysis Software

InterVenn Biosciences has made its proprietary mass spectrometry analysis software available for public use. Powered by artificial intelligence and machine learning, OpenPIP reduces the time and cost of integrating and quantifying mass spec data while increasing the quality of output by eliminating observer-based bias. The software is accessed via the Google Cloud Platform and has demonstrated greater than 99 percent concordance with human peak selection, the company said. A publication detailing the specific neural network architecture is currently undergoing peer review. 

Dec 05, 2019

Dante Labs: Whole GenomeH

Dante Labs has launched Whole GenomeH, a next-generation sequencing-based testing service featuring genome assembly with both long and short read technologies.

The test, which costs $1,999, uses both Illumina NovaSeq and Oxford Nanopore Technologies PromethIon sequencing systems.

Dec 04, 2019

Macrogen: Northeast Asia Reference Database

Macrogen of Korea has released the Northeast Asian Reference Database (NARD). It includes whole-genome sequencing and genetic variant data for a panel of 1,779 individuals, including 850 Koreans, 384 Mongolians, 396 Japanese, 91 Chinese, and 58 Hong Kong residents, making it the largest reference panel representing those countries, according to the company. Macrogen expects the database will help improve the accuracy of imputation in genome-wide association studies and predict disease based on polygenic risk scores. Early next year, the company plans to release a second reference panel, from 10,000 individuals.

Dec 04, 2019

Quadrant Biosciences Clarifi ASD

Quadrant Biosciences has launched Clarifi ASD, an epigenetic test designed to aid in the diagnosis of autism spectrum disorder in children 18 months through six year of age. Quadrant said the test is based on regulatory RNAs and microbes in the saliva, and is the result of seven years of research in collaboration with SUNY Upstate Medical University and Penn State College of Medicine. Clarifi is a prescription-only, laboratory-developed test that is intended to be used as an additional tool to standard practices and only for children with a clinical suspicion of ASD, the company said. It is available in all states except New York.

Dec 03, 2019

SiO2 Materials Synergy Tube

SiO2 Materials Science has launched its Synergy Tube, a blood collection tube designed to optimize nucleic acid recovery and cancer tumor cells (CTCs) after blood draw. The firm said that researchers can extract cfDNA/cfRNA and cellular gDNA/RNA from the same tube, allowing users to pair results from the same sample. 

Nov 27, 2019

Devyser HBOC Kit for Hereditary Breast, Ovarian Cancer Testing

Swedish genetic test developer Devyser has launched the HBOC kit for hereditary breast and ovarian cancer testing. The kit is based on Devyser's proprietary next-generation sequencing library prep technology, and provides targeted sequencing of 12 genes in which mutations are associated with an increased risk of developing breast and ovarian cancer. The company said that the workflow takes less than 45 minutes. The HBOC kit is part of Devyser's NGS Oncology suite, complementing the company's BRCA kit that enables simultaneous screening of mutations in the BRCA1 and BRCA2 genes. The new kit is available in the EU and through Devyser distributors in several countries in the Middle East, Southeast Asia, China, South America, and Africa. Customers in countries in which Devyser does not have distributors currently (e.g. the US and Canada) can self-import the assay, a company spokesperson said.

Nov 26, 2019

10x Genomics: Visium Spatial Gene Expression Solution

10x Genomics has launched its Visium Spatial Gene Expression solution. The assay provides researchers the ability to map where gene activity is occurring in a tissue specimen, with whole-transcriptome analysis of up to hundreds of thousands of cells on a tissue section.

Visium builds on earlier products from Spatial Transcriptomics, which 10x acquired in 2018, offering five times more spots within a capture area while reducing the time it takes from three days to one day.

Visium also includes turn-key software and requires access to an optical microscope.

Nov 22, 2019

Biocept TRK Assay

Biocept said it has launched a new assay for detection of TRK proteins in circulating tumor cells, intended to help inform physicians of patients' NTRK fusion status, an actionable biomarker that can be used to qualify patients for treatment with TRK inhibitor therapies.

The launch brings the company's CLIA lab test menu to 20 assays, including a variety of other single-gene tests analyzed in either circulating cell-free DNA or CTCs, and a next-gen sequencing panel test for lung cancer biomarkers.

Nov 20, 2019

Thermo Fisher Scientific Applied Biosystems SeqStudio Genetic Analyzer for Human Identification

Thermo Fisher Scientific has launched the Applied Biosystems SeqStudio Genetic Analyzer for Human Identification, a capillary electrophoresis platform. The system is designed for small- to medium-sized forensic DNA and paternity laboratories. It has been validated according to Scientific Working Group on DNA Analysis Methods (SWGDAM) guidelines on several Applied Biosystems STR amplification kits. The instrument uses an integrated cartridge that combines a capillary array, polymer reservoir, and anode buffer.

Nov 19, 2019

HTG Molecular Diagnostics EdgeSeq Reveal V 2.0

HTG Molecular Diagnostics has released its HTG EdgeSeq Reveal data analysis software, version 2.0. The Tucson, Arizona-based firm said that the new software contains enhanced functionality, allowing rapid data analysis from the HTG EdgeSeq Autoimmune Panel.

Nov 15, 2019

MedGenome South Asian Research Genotyping Array (SARGAM)

MedGenome has introduced the South Asian Research Genotyping Array, which leverages MedGenome's proprietary database of 2.5 million variants unique to the South Asian population and not available in any publicly available genetic database. MedGenome will use sequence data generated in its facility in Bengaluru, India to continue to identify unique content for SARGAM, which is based on Thermo Fisher Scientific's Applied Biosystems Axiom genotyping arrays. MedGenome said that SARGAM is intended to enable discovery research involving South Asian population cohorts, and will be ideal for consumer genomics solutions like ancestry and pharmacogenomics for the South Asian population.

Nov 15, 2019

Takara Bio Cellartis Intestinal Epithelial Cells Kit

Takara Bio has launched the Cellartis Intestinal Epithelial Cells (from ChiPSC18) Kit. These small intestinal epithelial cells derived from human induced pluripotent stem cells express intestinal markers at levels comparable to that of adult small intestinal tissue. They also express drug metabolizing enzyme CYP3A4 and drug transporter PEPT1 at more physiologically relevant levels compared with Caco-2, the current gold standard of intestinal models, Takara said. Additionally, the monolayer of intestinal epithelial cells forms a functional barrier that can be used for predicting intestinal permeability. The cells provide an improved model for the study of absorption and metabolism of orally administered drugs, the company said.

Nov 15, 2019

CBR ReadyGen Pediatric Genetic Screening Service

CBR, a Los Angeles-based company specializing in newborn stem cell banking, has launched a new genetic service developed in collaboration with Sema4. ReadyGen is a genetic screening test that analyzes a child's DNA for more than 200 conditions that can affect children before the age of 10. These conditions are currently addressable through medication, dietary modification, newborn stem cell transplant, or other therapies, especially when detected early in a child's life, the company said. Parents can order ReadyGen online and all orders will be reviewed and approved by a physician to ensure they are medically appropriate for the child.

Nov 15, 2019

NuProbe VarTrace Sanger Assays

NuProbe Global has launched VarTrace Sanger assays for ultrasensitive detection and quantification of cancer mutations with variant allele frequencies down to 0.1 percent. The company specifically launched three assays covering EGFR mutations for non-small-cell lung cancer; BRAF mutations for melanoma and thyroid cancer; and FLT3, DNMT3A, IDH1, IDH2, KIT, NPM1 mutations for acute myeloid leukemia. The assays are based on the firm's proprietary blocker displacement amplification (BDA) technology, and are compatible with both cell-free DNA from blood plasma and tissue samples including formalin-fixed paraffin-embedded tissue, NuProbe said.

Nov 14, 2019

Loop Genomics Long-Read PCR Amplicon Sequencing Kit, Service

Loop Genomics has launched a new amplicon library prep kit and service for generating synthetic long sequence reads from long PCR amplicons on Illumina sequencers. The kit can be used for PCR fragments up to 3 kb in size and the service can process orders for PCR fragments up to 6 kb long.

Nov 14, 2019

Grifols AlphaID

Grifols has lunched the AlphaID, a cheek swab for use by doctors to screen patients with chronic obstructive pulmonary disease for alpha-1 antitrypsin deficiency, a rare, life-threatening genetic condition. Grifols said the swab is completely free, "from ordering to results," and leverages a US Food and Drug Administration-approved genotyping assay to screen for the 14 most prevalently reported genetic mutations associated with the condition, including the S,Z,F, and I alleles, as well as rare and null alleles. 

Nov 13, 2019

Personalis Whole-Genome Sequencing Service

Personalis has launched a new whole-genome sequencing service, extending its existing portfolio of comprehensive cancer omics tests, including targeted gene panels, exome, and transcriptome products. The company said that the new offering reflects its experience analyzing cancer samples across numerous biopharma oncology clinical trials, and takes advantage of "large-scale laboratory and data systems" developed as part of its WGS effort for the US Department of Veterans Affairs' Million Veteran Program.

Nov 08, 2019

Bio-Rad QX One Droplet Digital PCR System

Bio-Rad this week launched the QX One Droplet Digital PCR system at the Association for Molecular Pathology meeting. The QX One is a single instrument that automates each step of the droplet digital PCR workflow including droplet generation, amplification, and droplet reading. The instrument has the capacity to run five 96-well plates simultaneously, providing the ability to analyze up to 480 samples per day. The system can detect four colors simultaneously for eight-plex CNV detection, five-plex mutation detection, and four-plex gene expression detection. It is compatible with current ddPCR supermixes, assays, and kits.

Nov 08, 2019

Akoya Biosciences Motif PD-1/PD-L1 Panels

Akoya Biosciences has launched two multiplex immunofluorescence kits for profiling immuno-oncology biomarkers in the tumor microenvironment. The Motif PD-1/PD-L1 panels focus on PD-1 immune checkpoint blockade in lung cancer and melanoma. Each kit includes six immunofluorescence markers, plus nuclear counterstain, to capture the cellular interactions associated with PD-1/PD-L1 immune suppression. The kits are optimized for high-throughput staining on commonly used autostainers and rapid scanning on the Vectra Polaris multiplexed imaging system.

Nov 07, 2019

Ceres Nanosciences Nanotrap Virus Capture Kit

Ceres Nanosciences has launched the Nanotrap Virus Capture Kit, which concentrates whole virus particles from complex biological matrices resulting in high-quality input material for a range of downstream analytical methods such as multiplex nucleic acid, protein, and infectivity assays. The company said that it has data demonstrating the kit's compatibility with multiple commercial nucleic acid kits for influenza virus samples, as well as an application note demonstrating use of the technology to improve the detection of Zika virus in urine samples.

Nov 07, 2019

Ultivue UltiMapper Multiplex Immunofluorescence Kits

Ultivue has expanded its UltiMapper Multiplex Immunofluorescence Kit portfolio with a T-reg and MDSC kit. The UltiMapper I/O T-reg kit identifies regulatory T cells and cytotoxic T cells within the tumor context and allows for the phenotyping of activated double-positive T cells. The UltiMapper I/O MDSC kit enables the identification and characterization of myeloid-derived suppressor cells and allows researchers to differentiate M-MDSC from PMN-MDSC phenotypes. The new kits feature high-throughput whole-slide imaging using the same conventional IHC equipment and workflows as the previously released UltiMapper I/O PD-L1, UltiMapper I/O PD-1, UltiMapper I/O T-act, and UltiMapper I/O APC kits, the company said.

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The Los Angeles Times reports that a case of the novel coronavirus making people ill in China has been reported in the US. 

A bipartisan group of senators has introduced a bill seeking increased funding for certain fields, including synthetic biology, ScienceInsider reports. 

Discover magazine writes that paleoproteomics is increasing being used in archaeology, paleoanthropology, and paleontology, including a recent study of a 6,000-year-old ring. 

In Nucleic Acids Research this week: mutagenic effects of ultraviolet "A" light, post-transcription effects of synonymous mutations, and more.