New England Biolabs has released the WarmStart Multi-Purpose LAMP/RT-LAMP 2X Master Mix and the WarmStart Fluorescent LAMP/RT-LAMP Kit. The products allow researchers to perform efficient, high-throughput detection of nucleic acids using a variety of amplification detection methods. The master mix has dUTP and UDG for carryover prevention, can be used with highly buffered and acidic samples, and supports multiple detection methods including turbidity detection and non-pH-based colorimetric detection. The kit is a fully buffered Multi-Purpose LAMP/RT-LAMP 2X Master Mix and a fluorescent dye in one package.
Kromatid has launched dGH Screen, a new service for mapping the human genome in single cells that builds on the company's proprietary directional Genomic Hybridization (dGH) technology for measuring genome structure and structural variation. The service lets researchers discover SVs de novo at a resolution of 5 kb.
Codex DNA has released a full-length synthetic genome for the SARS-CoV-2 Delta variant (B.1.617), constructed and manufactured using the firm's BioXp 3250 synthetic biology benchtop system. The genome can be used by researchers to develop therapies, vaccines, and diagnostics to slow the spread of the variant. Overall, Codex currently offers 13 different SARS-CoV-2 synthetic genomes.
Alithea Genomics has launched the Mercurius BRB-seq kit for high-throughput and cost-efficient RNA-seq library preparation from different types of RNA samples. The kit relies on early sample barcoding followed by pooling, so hundreds of RNA samples can be processed in the same tube after the initial reverse transcription reaction. It is compatible with purified RNA, cell lysates, and blood RNA samples.
BC Platforms and Sentieon have jointly introduced integrated next-generation sequencing analysis software called BC|Genome X-10. The new product, which runs on the Microsoft Azure cloud, is targeted at commercial laboratories offering clinical NGS testing according to American College of Medical Genetics and Genomics (ACMG) or American Society of Clinical Oncology (ASCO) guidelines. The firms have been collaborating since 2018.
DNAStar has released version 17.3 of its Lasergene software for DNA, RNA, and protein sequencing assembly and analysis. The latest release adds viral genome analysis workflow support for Pacific Biosciences and Oxford Nanopore long-read sequences, including data from PCR-amplified fragments generated according to Artic network protocols. The update is optimized for genomic analysis and variant identification to support COVID-19 research.
GetMyDNA has launched its PGx Test Home Collection Kit, designed to provide individuals with information about how they might react to certain specific medications. GetMyDNA currently checks for 88 different medicaitions, and will add more as guidance is received from the US Food and Drug Administration, the company said. Individuals in any of the 50 US states can order a mail-in home collection kit through the company’s website, with free overnight shipping provided both ways. Test kit users self-collect samples with a non-invasive cheek swab, which are sent to Gravity Diagnostics, a CAP-accredited, CLIA-certified laboratory.
New England Biolabs has launched the NEBNext Immune Sequencing Kits, designed for sequencing full-length immune gene repertoires of B and T cells. The kits enable somatic mutation profiling of these cells via the expression of complete antibody chains. They include modular primer sets for the complete V, D, and J segments; full isotype information analysis covering IgM, IgD, IgG, IgA, and IgE; and TCR chain characterization. They also include a bioinformatic workflow using the Galaxy platform, based on the open-source pRESTO toolkit. Users may convert PCR copies derived from individual molecules into consensus sequences via template-switching Unique Molecular Identifier-based mRNA barcoding.
Biotium has released its ExoBrite EV Membrane Staining Kits, designed for fluorescent staining of exosomes or extracellular vesicles with little to no background. The stains are validated for flow cytometry, but also have potential applications in super-resolution imaging or other exosome-detection platforms, the company said. The kits are available with two-color options for FITC or PE channels. More color options for blue and red channels are coming soon, the company noted. The standard kit will offer 500 labeling reactions while the trial-size kit will offer 100 labeling reactions.
Becton Dickinson has launched a new benchtop cell analyzer called the FACSymphony A1. The compact instrument features the firm's FACSymphony technology, FACSDiva software, as well as optional BD Small Particle Detector technology. It is compatible with BD Horizon dyes and supports workflows detecting up to 16 colors or 19 parameters simultaneously.