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Jun 26, 2019

Expedeon Lightning-Link Metal Labeling Kits

Expedeon announced this week that it has introduced Lightning-Link Metal Labeling Kits for multiple immunoassay-based applications to support single cell analysis. According to Expedeon, the new kits will allow users to enhance the phenotypic analysis of heterogeneous cell populations, providing increased multiplexing capability compared to fluophore labeling, improved sample throughput, and research output. The firm also noted that the labeling kits only require about 30 seconds of hands-on time. 

Jun 25, 2019

GenScript Enhanced GenBrick Gene Synthesis Service

GenScript has launched an upgrade to its GenBrick Gene Synthesis platform, which gives researchers access to DNA sequences up to 200 kilobases long with 100 percent accuracy. GenScript said it has optimized the genome assembly process and enhanced its technology to better handle difficult sequences. It has also developed new technology to quickly and accurately create long DNA sequences in one step that are free of any mutations or negative clones. 

The GenBrick service has been tested and used in synthetic biology projects such as the Synthetic 2.0 Yeast Genome (Sc2.0) project, where it synthesized the long arm of yeast chromosome VI. 

Jun 24, 2019

Phitonex NovaFluor Dyes

Phitonex has launched a new suite of NovaFluor dyes, which the firm said allows researchers to rapidly increase the number of scientific questions they can answer per cell on extant flow cytometry instrumentation. According to Phitonex, the platform helps engineer optical properties to provide high resolution single cell analysis with flow cytometry. 

Jun 20, 2019

Phase Genomics ProxiMeta Platform

Phase Genomics has launched its new ProxiMeta platform, which includes a 8-pack ProxiMeta kit with cloud-based ProxiMeta Analysis. According to the firm, the platform allows users to assemble hundreds of genomes and associated plasmids, phages, and antibiotic resistance, and interactions between genetic elements in microbial cells and communities. Phase said that the eight-reaction kit uses improved chemistry, includes reagents needed to prepare a sequencing-ready library from a microbiome sample, and does not require specialized equipment.

According to the firm, applications include antimicrobial resistance genes discovery, capturing phage and horizontal gene transfer, understanding the relationship between the microbiome and the resistome, and high-quality metagenome assembly from microbiome samples.

Jun 20, 2019

Fluidigm Maxpar Imaging Mass Cytometry Kits; CyTOF Software; Labeling Kits

Fluidigm is launching a number of mass cytometry products in the third quarter. Three Imaging Mass Cytometry Maxpar panel kits are designed for immune-oncology research. Developed using pathologist-verified antibodies, the panels can be mixed and matched to profile tumor-infiltrating lymphocytes, immune cell activation states, and tissue architecture. By combining them as a single 18-marker panel, researchers can broadly profile activated tumor-infiltrating lymphocytes for single-cell analysis of tumor architecture from a single tissue scan, Fluidigm said.

In addition, Fluidigm will introduce new CyTOF software, designed to be used with the Hyperion Imaging System for cellular biomarker identification. According to the firm, the software streamlines the selection and acquisition of multiple regions of interest (ROI) from each slide. Researchers can remotely annotate those ROIs using brightfield reference images to guide automated batch acquisition of highly multiplexed images at 1-micron resolution. During image acquisition, researchers can visualize multiplexed images in real time across all detection channels to ensure data quality, Fluidigm said.

Finally, the company will introduce seven new cadmium metal labeling kits for mass cytometry. The isotopes are the first of a new series in development and will allow researchers to design and customize larger panels to advance biomarker discovery and therapeutic development, Fluidigm said.

Jun 19, 2019

Cytek Biosciences Aurora Flow Cytometer

Cytek Biosciences is launching the latest version of its Cytek Aurora flow cytometry system featuring five lasers and the ability to detect more than 30 colors from a single sample without changing optical filters. The system can be used with any fluorochromes excited by the onboard lasers, and offers high resolution of dim and rare populations, Cytek said. The system simplifies workflows, saves costs, and allows access to a greater choice of dyes and specificities for applications that require deep profiling of cell populations in a single sample, the company added.

Jun 19, 2019

BGI 676 Quality Genome Standard

BGI has introduced the 676 Quality Genome, a new standard and cost-effective solution for high quality de novo genome assembly using MGI's DNBSEQ and stLFR technologies. BGI defined the standard as having a contig N50 greater than 106 bases (>1Mb), scaffold N50 greater than 107 bases (>10 Mb), and, for the human genome, total assembled size larger than 6 Gb. The firm expects the standard's cost to be $1,000, on the upcoming MGISEQ-T7 sequencing platform.

According to BGI, the 676 Quality Genome can detect all types of structural variants and is ideal for assembling regions of the genome not well represented by the reference genome. The firm said that the 676 Quality Genome provides more accurate and comprehensive genetic predictions, since it assembles each person's genome individually and does not depend on a reference genome.

Jun 18, 2019

Biocept NGS Breast Panel

Biocept has launched its second multi-gene liquid biopsy product, the Target Selector NGS Breast Panel, which is run on Thermo Fisher Scientific's Ion Torrent next generation sequencing platform and is designed to enable the detection and monitoring of actionable genomic biomarkers associated with breast cancer. The company said the test, which will be marketed to physicians and researchers, has shown over 99 percent sensitivity with at least 90 percent specificity in internal validations. 

Jun 17, 2019

Qiagen Microbial Insights AR

Qiagen has launched Microbial Insights AR (QMI-AR), an integrated genomic database that provides curated, single-point entry access to four of the world's largest knowledgebases on antimicrobial resistance. Specifically, it integrates the Comprehensive Antibiotic Resistance Database (CARD), ResFinder, a National Institutes of Health AMRFinder database of resistance genes, as well as the ARG-ANNOT database of peptide markers. According to Qiagen, the database complements ARESdb, a comprehensive, regularly updated genomic knowledgebase on clinically relevant antibiotic resistance strains that the firm has made available to the global research community through a partnership with Ares-Genetics, a Curetis subsidiary. Qiagen said that it will offer QMI-AR through the CLC Microbial Genomics Module, an extension to the CLC Genomics Workbench bioinformatics software.

Jun 17, 2019

GeneCast RUO Kits

Chinese liquid biopsy firm GeneCast has launched a set of research-use-only kits for BRAF, EGFR, and JAK2 mutation detection. The firm claims technical sensitivity for the BRAF assay as low as 0.0001 percent, and for the EGFR and JAK2 kits of 0.01 percent. The products use the company's ADPS quantitative PCR method, and the firm said it is working on gaining approval to offer the products for clinical use, filing a PMA submission with the US Food and Drug Administration, for the EGFR assay for example. GeneCast plans to launch additional RUO kits for KRAS, NRAS, PIK3CA, pTERT, IDH1, and IDH2 by the end of this year.

Jun 17, 2019

Twist Bioscience Mouse Core Exome Panel

Twist Bioscience has launched the Mouse Core Exome Panel for target enrichment in next-generation sequencing. The comprehensive panel for research use is built from the most current databases.

Jun 17, 2019

Paragon Genomics CleanPlex NGS Panels

Paragon Genomics has launched a series of CleanPlex products for MGI sequencers. The firm now offers its CleanPlex for MGI Ready-to-Use NGS panels, which can be used for both MGI's OncoZoom Cancer Hotspot Panel and MGI's BRCA1 and BRCA2 Panel. Paragon also offers its CleanPlex for MGI Custom NGS panels, which allow researchers to build customized assays to address specific needs. The firm noted that its support staff will take custom orders, developing and delivering panels that are completely compatible with MGISEQ sequencers. In addition, Paragon is offering validated automation protocols ensuring that CleanPlex for MGI assays can work with the MGISP-960 Automated Sample Preparation System to produce the same results performed if done manually. 

Jun 14, 2019

BGI Whole Exome Sequencing Service

BGI Genomics has launched a clinical research whole exome sequencing service called BGI-Xome, which incorporates clinical interpretation services from UK-based Congenica. BGI will perform WES at its service laboratories, while interpretation will be completed by clinical scientists using the Congenica clinical decision support platform. According to BGI, Congenica's Interpretation platform will allow its service to provide a "gold-standard" and effective solution that eliminates the risk of users missing or misidentifying disease-linked mutations. 

Jun 13, 2019

Oxford Gene Technology SureSeq NGS Library Prep Kit

Oxford Gene Technology has released a new SureSeq library preparation kit for hybridization-based target capture in next-generation sequencing. According to the firm, the kit offers a streamlined protocol with enrichment by hybridization with a ready-to-use hybridization and wash buffer. It also reduces manual handling steps to increase reliability and throughput. The firm also said that the kit lowers duplication rates, leading to more accurate calling and more even coverage.

Jun 12, 2019

Patients Choice Laboratories UTI+ Test

Patients Choice Laboratories has launched the UTI+ molecular test for urinary tract infections. The Indianapolis-based company said the new test is part of its goal to be a full-service lab. It added that its gene- and molecular-based technologies provides uropathogenic and antibiotic resistance testing results within six hours after specimen receipt compared to up to three days with urinalysis by culturing. 

Jun 11, 2019

Genestack Omics Data Manager

Genestack has introduced Omics Data Manager, a system for cataloguing, curating, indexing, searching, and sharing multi-omics data. Omics Data Manager can serve as centralized repository for enterprises looking to implement the FAIR (Findable, Accessible, Interoperable, and Reusable) principles for biomedical data management. Omics Data Manager can be integrated into laboratory information management systems and third-party, upstream data analysis platforms, according to Cambridge, UK-based Genestack. 

Jun 07, 2019

Thermo Fisher Scientific Orbitrap Exploris 480, Orbitrap Eclipse Tribrid Instruments and Mass Spectrometry Software

Thermo Fisher Scientific launched a number of mass spectrometry instruments and software this week.

The Thermo Scientific Orbitrap Exploris 480 mass spectrometer enables more rigorous high-throughput protein identification, quantitation, and structural characterization. It has a smaller footprint than previous instrument versions and maintains high resolution, mass accuracy, and spectral quality.

The Thermo Scientific Orbitrap Eclipse Tribrid mass spectrometer has improved sensitivity over previous generations and is better able to characterize and quantify complex biomolecules and biological systems.

Both new instruments can be combined with the Thermo Scientific FAIMS Pro interface, a differential ion mobility device that improves selectivity and increases productivity across a range of proteomics workflows.

The new Thermo Scientific TraceFinder Software 5.0 offers quicker and easier access to information from Thermo Scientific TSQ Quadrupole and Q Exactive Hybrid Quadrupole-Orbitrap mass spectrometry platforms. In addition, the Thermo Scientific Almanac web-based application enables users to remotely access instruments to monitor their run status and data acquisition.

Jun 06, 2019

Arbor Biosciences MyNGS Guides MitoDeplete Kits

Arbor Biosciences, a division of Chiral Technologies, has launched MyNGS Guides MitoDeplete Kits as part of its catalog of guide RNA pools for targeted sequencing applications. This new depletion system combines Arbor's massively parallel, high-fidelity oligo synthesis platform with Cas enzymes for efficiently targeting unwanted molecules from NGS libraries. In-stock MitoDeplete catalog kits have been designed and validated for human and mouse applications, and the company can design and synthesize kits for other custom species on demand.

MitoDeplete kits are designed for use on any NGS library containing a significant percentage of mitochondrial DNA molecules, such as ATAC-Seq libraries. CRISPR-based depletion with MitoDeplete delivers up to a 95 percent reduction in mtDNA-derived molecules in a single-step process. The human and mouse kits are available for immediate shipment in an eight-reaction kit size. Kits for custom species can be produced on request through collaboration with one of the product scientists at Arbor.

Jun 06, 2019

Sciex TripleTOF 6600+ LC-MS/MS System

Sciex has launched the TripleTOF 6600+ LC-MS/MS System with ScanningSwath Acquisition alongside high-performance data processing with OneOmics in Sciex Cloud. The latest entry in Sciex's TripleTOF portfolio, the new platform incorporates simplified low-flow source technology to deliver accessible, sensitive and robust quantification; while multiple software-enabled improvements increase robustness and maximize system uptime, Sciex said.

Other features include OptiFlow Turbo V Source for all low-flow applications, with flow rates of 100 nL/min to 200 L/min; up to 100 Hz MS/MS scan speeds; and Analyst TF Software 1.8, which features scheduled ionization and target TIC function to give users temporal control over the number of ions entering the systems.

Sciex also introduced ScanningSwath Acquisition to be hosted on the system. This feature immortalizes samples by creating a digital data record of all detectable analytes, capturing more detail about potential markers than its predecessor, Sciex said.

Jun 04, 2019

Illumina VeriSeq NIPT Solution v2

Illumina has launched the VeriSeq NIPT Solution v2, a CE-IVD, next-generation sequencing-based approach to noninvasive prenatal testing. The new version expands the range of chromosomal and sub-chromosomal conditions associated with birth defects that laboratories can screen for. The assay provides information about fetal chromosomal status as early as 10 weeks of gestation using a single maternal blood draw, and provides an option to screen for aneuploidy in all autosomes, chromosomes X & Y, and partial deletions and duplications greater than 7 Mb across the genome. It is available in Europe and South Africa; registration is pending in Australia, Israel, and New Zealand.

Jun 04, 2019

Synthego Gene Knockout Kit v2

Synthego has launched its Gene Knockout Kit v2. The kit is based on a multi-guide strategy that employs up to three modified single guide RNAs targeting the same gene. These sgRNAs are spatially coordinated to reliably induce a fragment deletion of 21 or more base pairs. This intentional edit occurs at high frequency, increasing the probability of gene knockout, the company said. Each kit includes one tube of chemically modified multi-guide sgRNA, designed to target any human protein-coding gene, and the purchase of a kit includes free access to Synthego's ICE CRISPR Analysis Tool.

Jun 04, 2019

Tempus Integrated Molecular Evaluation (TIME) Trial

During this week's American Society of Clinical Oncology meeting, Tempus introduced Tempus Integrated Molecular Evaluation (TIME) Trial. This service features a proprietary technology platform that analyzes molecular and clinical data on cancer patients in real time to match people to clinical trials. TIME Trial only sends patients to prequalified academic and community cancer centers so those who qualify can enroll right away. 

Jun 03, 2019

Day Zero Diagnostics epiXact WGS Sequencing Service

Day Zero Diagnostics (DZD) has commercially launched its epiXact whole genome sequencing and analysis service for hospital-acquired infection outbreak investigations. According to DZD, the service allows hospital infection control teams to determine the relationships between infections during a suspected outbreak. The firm said that the service can provide results in two to three days and can help hospital confidently and quickly decide how to perform interventions for patient safety. 

Jun 03, 2019

NRGene DeNovoMax

NRGene has launched DeNovoMax, a product for assembling reference-level genomes for use in breeding and agriculture. 

DeNovoMax is a version of NRGene's legacy DeNovoMagic platform that maximizes efficiency by using a leaner library setup. DeNovoMax is designed to meet the needs of professional breeders and will be offered for the most popular homozygote species including wheat, tobacco, tomato, pepper, cotton, corn, soybean, and sunflower.

May 31, 2019

Bruker TimsTOF FleX, IntelliSlides, SCiLS Lab 2020

Bruker announced several new mass spectrometry products and workflows to be launched at the American Society for Mass Spectrometry Conference, held June 2-6 in Atlanta.

First, the company introduced the TimsTOF FleX mass spectrometer, which includes a software-switchable MALDI source adapted to the ESI TimsTOF Pro platform. This new combined ESI/MALDI capability enables spatially resolved omics, which the company calls SpatialOMx, on a single instrument. TimsTOF FleX comes with Bruker's prorietary 10-kHz SmartBeam 3D laser with true pixel fidelity for rapid, label-free MALDI imaging at high spatial resolution while preserving the 4D proteomics and phenomics sensitivity of the TimsTOF Pro in ESI mode. The approach enables researchers to gain insights into spatial molecular distributions in tissues from MALDI imaging, and to guide 4D omics molecular expression studies, for example on proteins, low-level cancer antigen peptides, lipids, glycans, metabolites, or xenobiotics, which cannot be observed by traditional staining or labelling techniques, the company said.

Bruker also launched IntelliSlides specifically designed to automate TimsTOF FleX workflows. The IntelliSlides come pre-inscribed with software-readable 'teach marks' on the conductive surface to indicate where to place the tissue sample, a bar code and tracking number. The company also released SCiLS Lab 2020 MALDI imaging software, now integrated with MetaboScape5.0 to provide automated annotations of lipids and metabolites in tissue molecular images in SpatialOMx.

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Holden Thorp is to be the new editor-in-chief of Science and its related journals.

A genetic analysis of salmon scales collected over the course of a century points to a sharp decline in the number of fish returning each year to river in British Columbia, CBC reports.

Adelaide University has suspended the head of an ancient DNA lab as its investigation of workplace bullying continues, Australia's ABC News reports.

In PNAS this week: gene expression profiles of adipocyte subtypes, computational approach for improving plant expressome analysis, and more.