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Yourgene Sage 32 Plex

Yourgene Health has launched the Sage 32 plex test, a high-throughput noninvasive prenatal testing and analysis solution for clinical laboratories. It runs on Thermo Fisher Scientific's Ion Torrent sequencing platform and allows 32 samples to be processed in parallel. The test, which will be available internationally, has improved performance due to workflow enhancements and upgraded analysis methods. Yourgene plans to launch a CE-IVD-marked version of the library preparation kit for the Sage 32 plex workflow in the coming months. The Sage test differs from Yourgene's other NIPT, the Iona test, in that it screens for a wider range of conditions, including trisomies 21, 18, and 13; sex chromosome aneuploidies; and clinically relevant microdeletions. The analysis uses a cloud-based bioinformatics solution called Sage Link.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.