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Yourgene Elucigene DPYD

Sep 18, 2019

UK-based Yourgene has launched the Elucigene DPYD assay, a CE-marked chemotoxicity diagnostic test that uses genotyping to identify cancer patients with dihydropyrimidine dehydrogenase (DPD) deficiency. The deficiency causes several and sometimes lethal side effects in patients treated with 5-fluorouracil (5-FU), which is metabolized by the DPD enzyme, encoded by the DPYD gene. Elucigene DPYD, which tests for six common genetic variations, conforms with Clinical Pharmacogenetics Consortium guidelines, which recommend testing for four clinically relevant mutations.

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Feb 28, 2020

TwinStrand Biosciences Duplex Sequencing Technology

TwinStrand Biosciences this week launched TwinStrand Duplex Sequencing Technology kits at the Advances in Genome Biology and Technology meeting. Duplex Sequencing is a biochemistry- and software-based enhancement to existing next-generation sequencing platforms that improves accuracy by more than 10,000-fold, the company said. Optimized chemistry enables users to complete library preparation in one to two days, while cloud-based informatics provide the ability to fully process, analyze, interpret, and graphically present multi-terabyte raw sequencing data. The company will offer its technology initially for two research applications: detection of minimal residual disease in acute myeloid leukemia patients, and a multi-species genetic toxicology assay for rapid identification of carcinogenic chemicals in preclinical testing, as well as detection of patients who have been environmentally exposed.

Feb 27, 2020

RareCyte PD-L1 Assay

RareCyte has launched its PD-L1 liquid biopsy assay, which the firm said will allow users to evaluate PD-L1 expression on circulating tumor cells in a patient's bloodstream. Customers can use the PD-L1 assay and the AccuCyte-CyteFinder system to process blood to cells for CTC enumeration and PD-L1 biomarker expression analysis, or process blood to plasma for optional cell-free DNA analysis. 

Feb 26, 2020

Meridian Bioscience: Air-Dryable qPCR Mix

Meridian Bioscience announced its Air-Dryable qPCR mix, a specialized master mix with a magnesium-containing formulation allowing air or oven drying protocols for ambient temperature-stable real-time PCR assays. The mix allows dry down and test stability at ambient temperature, eliminating the need for cold chain storage, the company said. It shows high performance in multiplex reactions following rehydration, which Meridian said makes it suited for automated high-throughput platforms. 

Feb 25, 2020

Blueprint Genetics Mitochondrial Genome Analysis

Blueprint Genetics, a Quest Diagnostics company, has introduced full mitochondrial genome DNA (mtDNA) analysis to its diagnostic panels to increase diagnostic potential across medical specialties such as cardiology, metabolic disease, neurology, ophthalmology, and hearing loss. The analysis uses hybridization-based capture of mtDNA and next-generation sequencing to detect low heteroplasmy levels of mtDNA SNVs, indels, and deletions. It includes sequencing and copy number variant analysis of the entire mitochondrial genome (37 genes) which can be ordered alone or added to any panel. It has also been added to 30 existing panels where mitochondrial DNA testing is expected to have an impact on the diagnostic potential.

Feb 25, 2020

Seven Bridges Aria

Seven Bridges has introduced Aria, a bioinformatics platform for analyzing genotypic and phenotypic data to inform drug discovery. The cloud-based platform features: extract, transform, and load (ETL) processes for managing and building cohorts from phenotypic data; a variant data warehouse for querying whole-genome sequences; and an interpretation framework. Aria also supports in silico exploration of the impact of inactivating genes.

Feb 25, 2020

Dovetail Genomics Micro-C, HiChIP Kits

Dovetail Genomics has launched the Dovetail Micro-C and HiChIP Kits. The Micro-C Kit is the latest offering in the company's suite of Hi-C products, offering researchers resolution of chromatin contacts down to the mono-nucleosome level. The Dovetail HiChIP combines Micro-C and ChIP-seq into one simple workflow that enables researchers to assay protein-directed alterations to chromatin architecture and its resulting impact on gene expression, the company said. Both products are made for short-read next-generation sequencing platforms.

Feb 25, 2020

Twist Bioscience Comprehensive Exome Panel, Targeted Methylation Sequencing Solution

Twist Bioscience has launched its Twist Comprehensive Exome Panel, an optimal next-generation sequencing target enrichment solution that includes more than 99 percent of protein coding genes. The panel expands on the content of the Twist Human Core Exome to include coverage of protein-coding genes from all three key public genetic databases: CCDS, RefSeq and GENCODE, providing best-in-class coverage of the most up-to-date content, the company said. In addition, the panel can be customized quickly and affordably. Because of the updated and comprehensive coverage, the new panel allows for increased confidence in variant detection experiments, as well as maximum sequencing efficiency and best coverage uniformity.

Twist has also introduced the Twist Targeted Methylation Sequencing Solution to enable the study of methylation pattern changes in research fields including cancer, epigenetics, and non-invasive prenatal testing. The Targeted Methylation Solution offers a high-throughput, highly uniform target enrichment solution to explore methylation. This product is now available for early access customers, the company said. 

Feb 25, 2020

S2 Genomics Singulator 100 System

S2 Genomics this week launched the Singulator 100 System at the Advances in Genome Biology and Technology meeting. The Singulator 100 automates the processing of solid tissue samples into suspensions of single cells or nuclei with high yields and from small samples for a wide range of single-cell biology and genomic analyses. The company said that this enables researchers to reproducibly prepare suspensions of high-quality, highly viable cells or nuclei with minimal variability. The system will begin shipping in spring of this year with kits available for single-cell and nuclei isolation.

Feb 25, 2020

Lexogen: RiboCop rRNA Depletion Kits for Bacteria

Lexogen has developed a set of new RiboCop rRNA Depletion Kits for bacteria, which it said efficiently removes 23S, 16S, and 5S rRNA from mixed bacterial samples and monocultures. According to the firm, RiboCop is offered as a standalone kit with the option to choose from three optimized probe mixes for depletion of either rRNA from mixed bacterial samples, or Gram-negative or Gram-positive bacteria grown in monoculture.

The technology uses a set of affinity probes designed for specific depletion of rRNA sequences, and, according to Lexogen, the probe design minimizes off-target effects that can distort NGS data quality. The kits work with total RNA input amounts as low as 1 ng and up to 1 μg, depending on sample composition and the chosen depletion probe mix. RiboCop does not include any enzymatic reactions or mechanical shearing steps and can process intact as well as degraded material, including FFPE, resulting in intact, full-length transcripts. Resulting rRNA-free samples are then suitable for a variety of downstream RNA analysis methods including RNA-seq library preparation approaches.

The protocol is also automation-friendly, the firm added.

Feb 25, 2020

Promega Corporation: Wizard HMW DNA Extraction Kit

Promega Corporation has launched its Wizard HMW DNA Extraction Kit, a tool for researchers working with large fragments of genomic DNA. According to the company, the new HMW DNA product, which joins the firm's existing portfolio of both manual and automated kits to extract a variety of nucleic acids from a broad range of sample types, allows researchers, in a 90-minute manual protocol, to obtain DNA that can provide strong performance in long-read sequencing applications. Data on this performance was demonstrated in a poster presented at this week's 2020 Advances in Genome Biology and Technology (AGBT) meeting, Promega said. When run through a long-read sequencing protocol, the DNA from the Promega kit produced very long maximum reads and high N50 values, indicating a higher proportion of large fragments in the sample. 

Compared to available alternatives, Promega claimed that the Wizard kit purifies a "significantly higher" proportion of fragments over 125kb. The kit supports purification from a variety sample types including whole blood, bacterial cultures, cultured mammalian cells, and plant leaf tissue.

Feb 21, 2020

Bio-Rad Laboratories: EDX RP Positive Run Control

Bio-Rad Laboratories said that Exact Diagnostics has launched the EDX RP Positive Run Control, an unassayed external quality control for monitoring the performance of clinical respiratory assays. Bio-Rad acquired Exact Dx in the third quarter of 2019. Routine use of the EDX RP Positive Run Control allows labs to meet their individualized quality control goals, such as the evaluation of reagent lot changes and new shipments, Bio-Rad said. The control also monitors multiple identical devices and provides an evaluation of different personnel and locations. It contains 22 respiratory analytes that are internally value-assigned using Bio-Rads Digital Droplet PCR technology and is designed to test the entire process of a molecular assay, including extraction, detection, and amplification. 

Feb 19, 2020

Covaris Viral RNA Extraction Kits

Covaris has launched two new kits for viral RNA extraction from nasal or throat swab sample collection devices. The truXTRAC Viral RNA Extraction kit uses Puritan swabs and contains all components for the firm's adaptive focused acoustics-based extraction as well as magnetic bead-based purification of high-quality RNA from synthetic swabs. The truXTRAC-PCR Direct Viral RNA Extraction kit can be used directly in real time RT-PCR assays without prior purification, provided an internal control is included.

Feb 19, 2020

Integrated DNA Technologies xGen Prism DNA Library Prep Kit

Integrated DNA Technologies (IDT), a Danaher company, has launched the xGen Prism DNA Library Prep Kit, which is designed for challenging and low-quality samples. The kit can convert cell-free DNA and DNA from formalin-fixed paraffin-embedded tissue into high-quality next-gen sequencing libraries. It greatly reduces adapter dimers and uses unique molecular identifiers (UMIs) for enhanced error correction.

Feb 18, 2020

Thermo Fisher Scientific Applied Biosystems PowerTrack SYBR Green PCR Master Mix

Thermo Fisher Scientific has released the Applied Biosystems PowerTrack SYBR Green PCR Master Mix. It is designed for real-time PCR workflows and is compatible with all qPCR instruments. It contains a two-color tracking dye system to help researchers keep track of where they have pipetted. The mix uses an antibody-mediated hot-start mechanism to control activation of the Taq enzyme. It also includes UNG and dUTP enzymes to prevents previously amplified PCR products from contaminating subsequent qPCR reactions. The mix provides results ranging from 0.1 pg to 100 ng of complementary DNA per reaction and can be used in standard or fast cycling mode.

Feb 18, 2020

Nebula Genomics: 30X Whole-Genome Sequencing Service

Nebula Genomics has launched a new, direct-to-consumer whole-genome sequencing service. Performed with MGI DNBSEQ T-Series instruments in BGI's global network of sequencing centers, Nebula's service offers 30X coverage for $299.

Individuals who sequence their genome through Nebula will retain full control of their genomic data, the firm added in a statement.

According to NPR, an antibody-based test could identify people who were exposed to SARS-CoV-2 and either didn't develop symptoms or were misdiagnosed.

A sequencing analysis of New York City rats indicates they have adapted to the urban environment there, according to a recent preprint.

Ars Technica reports that a multicellular eukaryotic parasite has lost its mitochondria.

In Science this week: perspective piece says AI can accelerate drug discovery by using genomic and chemical data, and more.

Mar
31
Sponsored by
Isoplexis

This webinar will discuss the application of single-cell proteomics and immune-imaging in adoptive cell therapy (ACT) for cancer.