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Xcell NGS System for Cell-Based Assays

Xcell Biosciences said this week that the company will unveil its Avatar system at the Molecular Medicine Tri-Conference next week in San Francisco. The new system enables a new generation of cell-based assays by allowing for complete control of key physiological conditions found in the microenvironments of cells, the company said. It also overcomes the limitation of traditional cell culture to generate results that exhibit the phenotypic, genomic, and proteomic characteristics of the native sample, the company said.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.