WaferGen ICell8 Single-Cell System

Oct 06, 2015

WaferGen Biosystems launched the ICell8 single-cell system. The SmartChip-based platform can isolate thousands of cells and process specific cells for analysis, including next-generation sequencing.

The system incorporates CellSelect automated imaging and software and the ability to run multiple samples or experiments on a single chip, by partitioning the chip in as many as eight sections.

Single cells from solid tumors, brains cells, pulmonary airway cells, multiple cell lines, and nuclei, ranging from 5 to 100 µm in size, can be isolated and dispensed into a single chip without pre-selection or filtering.

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Jul 24, 2017

Helix Genomics Marketplace

Personal genomics company Helix announced the opening of an online marketplace where customers can have their DNA sequence interpreted in a variety of contexts, including health, fitness, nutrition, recreation, family, and ancestry. The marketplace features mobile applications developed by partner companies: Admera, Azumio, DNAFit, DotOne, EverlyWell, Exploragen, Genome Medical, Insitome, Intelliseq, Lose It!, National Geographic, Sema4, Titanovo, and Vinome.

The initial exome sequencing through Helix is $80, in addition to the cost for each app. For example, Sema4's CarrierCheck app enabling screening for 67 conditions is available for $199. Instiome's app, for $29.99, allows customers to learn traits they may have inherited from Neanderthal ancestors, such as skin pigmentation, the ability to repair sun damage, learning capabilities, and torso shape. 

Additionally, customers can order an app from Admera for cardiac risk, inherited cholesterol and diabetes testing; learn about their genetic ancestry from National Geographic's app; learn about how their DNA might impact sleep patterns from Exploragen; order a variety of apps for weight management and fitness based on DNA information; and receive a DNA-based taste profile from Vinome. Nursing mothers can learn their levels of the Omega 3 fatty acid in breast milk via an app from EverlyWell. An app from DotOne will let individuals order a scarf with their own DNA information printed on it.

Before or after receiving any particular interpretation, customers can also get genetic counseling through Genome Medical's telemedicine network of genetic counselors.

Jul 21, 2017

CloudLIMS Lite

CloudLIMS has released a new version of its pay-as-you-go LIMS, CloudLIMS Lite, to help biobanks and clinical, research, and testing laboratories keep track of their biospecimens and testing workflows. The new version is more efficient in facilitating testing and reporting of multiple analytes, the company said. The software can create analyte groups for each test and configure one or more analytes under a group; specify range for every analyte and create flagging sets such as high, low, critical high, critical low, et cetera, to flag test results based on obtained values; and publish test reports containing multiple analytes, among other functionalities.

Jul 20, 2017

Thermo Fisher Scientific Applied Biosystems Precision ID GlobalFiler NGS STR Panel v2, Converge Software 2.0

Thermo Fisher Scientific has released the Applied Biosystems Precision ID GlobalFiler NGS STR Panel v2 and Converge Software 2.0 for forensic research. The products are designed to retrieve more information from mixed, degraded, or limited DNA samples. The new panel works with the Ion Chef system for library and template preparation and the Ion S5 and Ion S5 XL sequencing systems. It targets expanded core loci from the Combined DNA Index System (CODIS), with additional multi-allelic STR markers, including Penta D and Penta E, and sex determination markers. The new software module is required to generate profiles from the panel. It provides information on length-based STR allele calls, sequence-based repeat motifs, known SNPs in flanking regions, and isometric heterozygotes. 

Jul 20, 2017

Thermo Fisher Scientific Applied Biosystems Axiom Asia Precision Medicine Research Array

Thermo Fisher Scientific has launched the Applied Biosystems Axiom Asia Precision Medicine Research Array. The array contains more than 750,000 biomarkers associated with both common and rare diseases, including more than 100,000 variants shown to have pathogenic effects in East Asian and South Asian populations. In addition, 50,000 custom markers can be added. 

Jul 19, 2017

LabCorp ADAMTS13 Test

Laboratory Corporation of America began offering the ADAMTS13 test for a rare life-threatening blood-clotting disorder. The test distinguishes diseases characterized by acute thrombotic microangiopathy (TMA), a relatively rare syndrome in which small blood vessels develop blood clots. The test can provide faster and more accurate results, compared to other tests, to rule in or out the diagnosis of thrombotic thrombocytopenia purpura, a condition that can cuase TMA, and to support decisions whether to start patients on certain therapies, LabCorp said. The test is run on liquid chromatography-tandem mass spectrometry technology.

Jul 19, 2017

Quest Diagnostics QHerit Screening Service

Quest Diagnostic launched QHerit, a genetic screening service that tells individuals their risk of passing on heritable disorders to future generations. The QHerit Pan-Ethnic Expanded Carrier Screen provides information for 22 heritable diseases cited under new screening guidelines issued earlier this year by the American College of Gynecology. In addition to more well-known heritable disorders such as cystic fibrosis and sickle cell disease, QHerit also identifies lesser-known mutations associated with Joubert Syndrome 2 and fragile X syndrome. It also screens for spinal muscular atrophy and includes the evaluation of hemoglobinopathies.

Jul 18, 2017

Agilent Technologies SureSelectXT HS NGS Library Prep

Agilent Technologies has launched the Agilent SureSelectXT HS, its newest next-generation sequencing library prep product. SureSelectXT HS provides total workflow management for laboratories, from QC to target enrichment, analysis, and interpretation, the company said. It's optimized for labs with a requirement to sequence DNA from formalin-fixed paraffin-embedded samples, which may have degraded over time. SureSelectXT HS also incorporates molecular barcodes, improving overall precision and producing high complexity libraries on a broad range of tissue types and low- and high-quality FFPE samples. SureSelectXT HS libraries require as little as 10 ng of starting DNA, and use molecular barcodes to assist error correction. Additionally, faster and more efficient processing with master-mixed reagents that require less hands-on time, coupled with a 90-minute hybridization enables labs to now move from sample to sequencer in a single day.

Jul 18, 2017

Fluidigm Advanta Immuno-Oncology Gene Expression Assay

Fluidigm has launched the Advanta Immuno-Oncology Gene Expression Assay, a research-use-only qPCR assay that enables interrogation of tumor immunobiology using Fluidigm's microfluidic technology. Designed for use with the Biomark HD system, the assay detects 170 gene expression markers involved in checkpoint therapeutic response from FFPE and fresh frozen tumor samples. The assay can analyze biomarkers across defined T cell subsets, immune regulation, immune cell fate, cytokines, chemokines, and more, and can enable translational researchers to accelerate the development of checkpoint immunotherapies and to identify predictive biomarker signatures for therapeutic response.

Fluidigm said that the product is available as a two-panel set. The first panel includes 91 key markers of tumor immune response that were previously shown in a multicenter international clinical trial to inform tumor progression and checkpoint therapeutic response. The second panel includes 74 additional immuno-oncology markers and 17 open assay inlets for additional customization. Both panels contain the same five reference genes and can be purchased and used together or separately.

Jul 18, 2017

Empirical Bioscience 2X qPCR Probe Master Mix

Empirical Bioscience has released 2X qPCR Probe Master Mix for probe-based quantitative PCR applications. This new product is for real-time evaluation of DNA using fluorescent probe-based detection. It contains FlashTaq HotStart DNA polymerase, a chemically modified Taq DNA polymerase that remains inactive at room temperature but becomes activated after 2 minutes at 95° C. The master mix also contains dNTPs, MgCL2, and optimized buffer for fast, efficient qPCR. It has been optimized for use with hydrolysis-based probes such as TaqMan, but is also suitable with other probe-based detection systems. The mix is available in multiple versions for various applications including bulk and custom volumes for commercial and biotech.
Jul 18, 2017

Seraseq Circulating Tumor DNA v2 Reference Materials

SeraCare Life Sciences has launched a new set of ctDNA reference materials to aid development and validation of liquid biopsy assays. The new Seraseq Circulating Tumor DNA v2 reference materials were produced using a unique technology that produces a DNA fragment size-distribution which closely mimics native cfDNA, while decreasing DNA damage relative to ultrasonicated material, the company said.

The new product requires no special workflow considerations to generate informative data, and contains 40 somatic mutations, including important targets like BRAF V600E, KRAS G12D, and various EGFR alterations. Variants are present against a single well-characterized genomic background across a range of allele frequencies down to 0.125 percent, which ensures utility for assays with different limits of detection.

Jul 14, 2017

UCSF mNGS Test

The University of California, San Francisco's Center for Next-Gen Precision Diagnostics has launched a metagenomic next-generation sequencing test for neurological infections. Physicians can order the test for patients with idiopathic meningitis or encephalitis with unknown etiology. Testing is performed on cerebrospinal fluid. The testing process takes around 72 hours and results are reported back within one to two weeks. Charles Chiu, director of UCSF's Viral Diagnostics and Discovery Center, most recently described the test at a conference in February.

Jul 14, 2017

Biocept Progesterone Receptor Liquid Biopsy Test

Biocept has announced the commercial availability of its liquid biopsy test for progesterone receptor (PR), which can be used for the detection and monitoring of a key biomarker in the blood of patients with breast cancer. The company noted that the ability to detect PR expression in circulating tumor cells complements its existing ER and HER2 assays for biomarker analysis in breast cancer. Biocept's Target Selector PR expression test is performed on circulating tumor cells using fluorescently labeled antibodies. The company's liquid biopsy tests are performed in its CLIA-certified, CAP-accredited laboratory in San Diego.

Jul 12, 2017

Norgen Small RNA Library Prep Kit and Sequencing Services

Norgen Biotek, based in Ontario, has launched a Small RNA Library Prep Kit for Illumina sequencing instruments as well as sequencing services on Illumina instruments. The Small RNA Library Prep Kit needs between 0.5 nanograms and 1 nanogram of input RNA and can process samples from plasma, serum, blood, cerebral spinal fluid, urine, and exosomes, according to the company. Turnaround time is less than five hours. Norgen also offers complementary products, including NGS-compatible cel-miR-39 spike-in and an NGS library quantification kit. The services Norgen launched include isolation, library prep, sequencing, and bioinformatics. Sequencing can be performed on Illumina's MiSeq or NextSeq 500 instruments and includes small RNA-seq, RNA-seq, 16S metagenomics, targeted DNA or RNA sequencing, exome sequencing, and whole-genome sequencing.  

Jul 12, 2017

Exact Diagnostics Verification Panels

Exact Diagnostics launched its verification panels for IVD use. The panels include adenovirus; BKV; CMV; EBV; HBV; HCV; HHV-6A; HHV-6B; HIV-1; HSV-1; HSV-2; VZV; and Zika. They can be used to establish reference points to measure various analytes in molecular assays, the firm said. 

Jul 07, 2017

LGC High-Throughput Liquid Handling for PCR

LGC has launched the Meridian2 liquid dispensing system, a non-contact, on-the-fly dispenser suited to a wide range of dispensing applications, including reagents for genotyping and standard PCR. The Meridian2 features two plate positions for enhanced efficiency, integrated barcode reading, and automated assay mixing. It integrates into laboratories with existing SNPline automation or other Meridian instruments. The platform accurately dispenses 1-μL volumes into a 1,536-well plates in less than 45 seconds, with a CV of less than 5 percent, and the vacuum-based aspiration system allows multi-plate dispense for increased efficiency.

Technology Review reports that researchers in the US have used CRISPR to modify a number of human embryos.

By introducing genes from butterfly peas and Canterbury bells, researchers in Japan have developed a blue chrysanthemum, according to NPR.

Plant researchers plan to sequence some 10,000 samples that represent the major plant clades, ScienceInsider reports.

In Nature this week: a Danish reference genome, and more.