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Ultivue UltiMapper Multiplex Immunofluorescence Kits

Ultivue has expanded its UltiMapper Multiplex Immunofluorescence Kit portfolio with a T-reg and MDSC kit. The UltiMapper I/O T-reg kit identifies regulatory T cells and cytotoxic T cells within the tumor context and allows for the phenotyping of activated double-positive T cells. The UltiMapper I/O MDSC kit enables the identification and characterization of myeloid-derived suppressor cells and allows researchers to differentiate M-MDSC from PMN-MDSC phenotypes. The new kits feature high-throughput whole-slide imaging using the same conventional IHC equipment and workflows as the previously released UltiMapper I/O PD-L1, UltiMapper I/O PD-1, UltiMapper I/O T-act, and UltiMapper I/O APC kits, the company said.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.