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UCSF mNGS Test

The University of California, San Francisco's Center for Next-Gen Precision Diagnostics has launched a metagenomic next-generation sequencing test for neurological infections. Physicians can order the test for patients with idiopathic meningitis or encephalitis with unknown etiology. Testing is performed on cerebrospinal fluid. The testing process takes around 72 hours and results are reported back within one to two weeks. Charles Chiu, director of UCSF's Viral Diagnostics and Discovery Center, most recently described the test at a conference in February.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.