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Twist Bioscience Clonal-Ready Gene Fragments

Twist Bioscience has launched clonal-ready gene fragments. The synthetic DNA products are available with and without adapters and can be used to build constructs. Potential applications include cloning, gene and protein expression, pathway and enzyme engineering, and enzyme optimization.

Gene fragments begin as oligonucleotides, are annealed, and amplified to produce double-stranded DNA fragments. They are error-corrected in an enzymatic reaction. The error rate is 1 in 5,300 base pairs; for shorter oligonucleotides between 300 and 800 base pairs long, the error rate drops to 1 in 6,200.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.