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Twist Bioscience Clonal-Ready Gene Fragments

Twist Bioscience has launched clonal-ready gene fragments. The synthetic DNA products are available with and without adapters and can be used to build constructs. Potential applications include cloning, gene and protein expression, pathway and enzyme engineering, and enzyme optimization.

Gene fragments begin as oligonucleotides, are annealed, and amplified to produce double-stranded DNA fragments. They are error-corrected in an enzymatic reaction. The error rate is 1 in 5,300 base pairs; for shorter oligonucleotides between 300 and 800 base pairs long, the error rate drops to 1 in 6,200.

The Scan

Renewed Gain-of-Function Worries

The New York Times writes that the pandemic is renewing concerns about gain-of-function research.

Who's Getting the Patents?

A trio of researchers has analyzed gender trends in biomedical patents issued between 1976 and 2010 in the US, New Scientist reports.

Other Uses

CBS Sunday Morning looks at how mRNA vaccine technology could be applied beyond SARS-CoV-2.

PLOS Papers Present Analysis of Cervicovaginal Microbiome, Glycosylation in Model Archaea, More

In PLOS this week: functional potential of the cervicovaginal microbiome, glycosylation patterns in model archaea, and more.