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TwinStrand Biosciences Duplex Sequencing Technology

TwinStrand Biosciences this week launched TwinStrand Duplex Sequencing Technology kits at the Advances in Genome Biology and Technology meeting. Duplex Sequencing is a biochemistry- and software-based enhancement to existing next-generation sequencing platforms that improves accuracy by more than 10,000-fold, the company said. Optimized chemistry enables users to complete library preparation in one to two days, while cloud-based informatics provide the ability to fully process, analyze, interpret, and graphically present multi-terabyte raw sequencing data. The company will offer its technology initially for two research applications: detection of minimal residual disease in acute myeloid leukemia patients, and a multi-species genetic toxicology assay for rapid identification of carcinogenic chemicals in preclinical testing, as well as detection of patients who have been environmentally exposed.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.