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Thermo Fisher Oncomine Focus Assay; TaqMan Assays

Thermo Fisher Scientific has launched the Oncomine Focus Assay, a multi-biomarker, next-generation sequencing panel that includes 52 solid tumor genes associated with current oncology drugs and published evidence. The Oncomine Focus Assay allows concurrent analysis of DNA and RNA, enabling sequencing of 35 hotspot genes, 19 genes associated with copy number gain and 23 fusion genes, all in a single workflow using the Ion PGM System. The assay also leverages Ion AmpliSeq technology's low DNA and RNA sample input requirements from FFPE tissue (10 ng of extracted nucleic acid per reaction for a total of 20 ng per sample) to enable accurate and reliable sequence analysis across a large range of tumor sample types, including small biopsies and fine-needle aspirates.

As a complement to this new assay, Thermo Fisher Scientific has also introduced a set of new TaqMan research assays designed to detect fusion transcripts using real-time PCR. These assays can be used as an orthogonal confirmation method during the implementation of this NGS workflow, the company said.

The Scan

Study Links Genetic Risk for ADHD With Alzheimer's Disease

A higher polygenic risk score for attention-deficit/hyperactivity disorder is also linked to cognitive decline and Alzheimer's disease, a new study in Molecular Psychiatry finds.

Study Offers Insights Into Role of Structural Variants in Cancer

A new study in Nature using cell lines shows that structural variants can enable oncogene activation.

Computer Model Uses Genetics, Health Data to Predict Mental Disorders

A new model in JAMA Psychiatry finds combining genetic and health record data can predict a mental disorder diagnosis before one is made clinically.

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.