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TATAA Biocenter Alu Assays

TATAA Biocenter is now offering ultra-sensitive qPCR assays targeting human-specific Alu repeats, which comprise about 10 percent of the human genome. The assays are available for different target lengths, which makes it possible to characterize the integrity of gDNA. The ration measured with TATAA ALU-60, which amplifies 60-bp targets, to TATAA ALU-187, which amplifies 187-bp targets, assesses the level and fraction of cell-free DNA in liquid biopsy samples. The assays can detect even miniscule amounts of human genomic DNA contamination, and contaminated reagents can be cleaned with the Heat/Run gDNA removal kit. The ALU quality control panel was in part developed for the CANCER-ID consortium, TATAA said.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.