Skip to main content
Premium Trial:

Request an Annual Quote

Takara Bio Cellartis Intestinal Epithelial Cells Kit

Takara Bio has launched the Cellartis Intestinal Epithelial Cells (from ChiPSC18) Kit. These small intestinal epithelial cells derived from human induced pluripotent stem cells express intestinal markers at levels comparable to that of adult small intestinal tissue. They also express drug metabolizing enzyme CYP3A4 and drug transporter PEPT1 at more physiologically relevant levels compared with Caco-2, the current gold standard of intestinal models, Takara said. Additionally, the monolayer of intestinal epithelial cells forms a functional barrier that can be used for predicting intestinal permeability. The cells provide an improved model for the study of absorption and metabolism of orally administered drugs, the company said.

The Scan

Booster Push

New data shows a decline in SARS-CoV-2 vaccine efficacy over time, which the New York Times says Pfizer is using to argue its case for a booster, even as the lower efficacy remains high.

With Help from Mr. Fluffington, PurrhD

Cats could make good study animals for genetic research, the University of Missouri's Leslie Lyons tells the Atlantic.

Man Charged With Threatening to Harm Fauci, Collins

The Hill reports that Thomas Patrick Connally, Jr., was charged with making threats against federal officials.

Nature Papers Present Approach to Find Natural Products, Method to ID Cancer Driver Mutations, More

In Nature this week: combination of cryogenic electron microscopy with genome mining helps uncover natural products, driver mutations in cancer, and more.