Synthego announced the availability of modified synthetic single guide RNA (sgRNA) libraries for arrayed whole human genome CRISPR screening. The arrayed libraries are delivered ready-to-screen and have comprehensive coverage of the human genome, with several guide RNAs selected per gene, using the latest algorithms to enhance knockout efficiency. This leads to superior screening capabilities over RNAi and CRISPR pooled libraries, enabling a better understanding of gene function and smarter identification of drug targets for complex diseases, the company said. The Synthego whole human genome library is available in gene families including the druggable genome, transcription factors, G-protein coupled receptors, kinases, and immunology and immuno-oncology targets, among others. This feature enables focused CRISPR screens, allowing hypothesis-driven gene targeting and running of simultaneous screens without overlap.
For a full list of the gene families visit: www.synthego.com/libraries