Skip to main content
Premium Trial:

Request an Annual Quote

Synthego Modified Synthetic sgRNA Libraries for Arrayed Whole Genome CRISPR Screening

Synthego announced the availability of modified synthetic single guide RNA (sgRNA) libraries for arrayed whole human genome CRISPR screening. The arrayed libraries are delivered ready-to-screen and have comprehensive coverage of the human genome, with several guide RNAs selected per gene, using the latest algorithms to enhance knockout efficiency. This leads to superior screening capabilities over RNAi and CRISPR pooled libraries, enabling a better understanding of gene function and smarter identification of drug targets for complex diseases, the company said. The Synthego whole human genome library is available in gene families including the druggable genome, transcription factors, G-protein coupled receptors, kinases, and immunology and immuno-oncology targets, among others. This feature enables focused CRISPR screens, allowing hypothesis-driven gene targeting and running of simultaneous screens without overlap.

For a full list of the gene families visit: www.synthego.com/libraries

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.