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Synthego High-Throughput Induced Pluripotent Stem Cell Genome Engineering

Synthego has launched a genome engineering service for induced pluripotent stem (iPS) cells. The new offering expands on Synthego's automated cell editing technology to achieve high editing efficiency of iPS cells at an industrial scale. Synthego said its cell-editing platform makes editing, cloning, and maintaining high pluripotency in clinically relevant iPS cells easier, with editing rates as high as 90 percent prior to cloning and 100 percent in clones. The new offering of iPS cells includes modifications by gene knockout, single-nucleotide variation, protein tagging, and other knock-ins.

The Scan

RNA Editing in Octopuses Seems to Help Acclimation to Shifts in Water Temperature

A paper in Cell reports that octopuses use RNA editing to help them adjust to different water temperatures.

Topical Compound to Block EGFR Inhibitors May Ease Skin Toxicities, Study Finds

A topical treatment described in Science Translational Medicine may limit skin toxicities seen with EGFR inhibitor therapy.

Dozen Genetic Loci Linked to Preeclampsia Risk in New GWAS

An analysis of genome-wide association study data in JAMA Cardiology finds genetic loci linked to preeclampsia that have ties to blood pressure.

Cancer Survival Linked to Mutational Burden in Pan-Cancer Analysis

A pan-cancer paper appearing in JCO Precision Oncology suggests tumor mutation patterns provide clues for predicting cancer survival that are independent of other prognostic factors.