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Synthego CRISPRevolution Gene Knockout Kit

Synthego has launched its new CRISPRevolution Gene Knockout Kit (GKO) for all CRISPR researchers, including those developing emerging therapeutic modalities with increasing genome engineering demands such as CAR-T immunotherapy and treatment of monogenic diseases. The CRISPRevolution GKO includes four top-scoring guides from Synthego's CRISPR Design Tool, provided as high efficiency chemically modified synthetic sgRNAs, SpCas9 protein, and control reagents to optimize transfection protocols. This kit has an easy-to-use experimental workflow, and comes with a money-back guarantee on 50 percent or better editing in any human cell type for research use.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.