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Sygnis TruePrime RCA Kit

Sygnis has launched the TruePrime RCA kit for the direct amplification of circular DNA targets. Combining Sygnis' proprietary DNA primase TthPrimPol with its Phi29 polymerase, the TruePrime technology does not need synthetic random primers to start the reaction. The TruePrime RCA kit enables direct amplification of plasmids from purified DNA or bacteria, reducing time involved in this standard process from 18 hours to 1 hour. Additionally, the kit can be used to amplify large circular vectors such as BACs and cosmids needed for genetic manipulation, Sygnis said.

The Scan

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.

Fragile X Syndrome Mutations Found With Comprehensive Testing Method

Researchers in Clinical Chemistry found fragile X syndrome expansions and other FMR1 mutations with ties to the intellectual disability condition using a long-range PCR and long-read sequencing approach.

Team Presents Strategy for Speedy Species Detection in Metagenomic Sequence Data

A computational approach presented in PLOS Computational Biology produced fewer false-positive species identifications in simulated and authentic metagenomic sequences.

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.