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SGI-DNA's Gibson Assembly Site-Directed Mutagenesis Kit

SGI-DNA has launched the Gibson Assembly Site-Directed Mutagenesis Kit which allows researchers to efficiently and accurately perform site-directed mutageneisis on DNA fragments. The Gibson Assembly method has become a mainstay in many synthetic biology laboratories and has attracted interest from both the academic and commercial life sciences community due to its ease of use, robustness, and flexibility, said SGI-DNA in a statement. Starting with a circular or a linear DNA template up to 25 kilobases in length, the kit enables researchers to introduce up to five site-directed mutations in a single round with efficiencies of 95 percent and 55 percent, respectively.

The Scan

Cancer Survival Linked to Mutational Burden in Pan-Cancer Analysis

A pan-cancer paper appearing in JCO Precision Oncology suggests tumor mutation patterns provide clues for predicting cancer survival that are independent of other prognostic factors.

Australian Survey Points to Public Support for Genetic Risk Disclosure in Relatives of At-Risk Individuals

A survey in the European Journal of Human Genetics suggests most adult Australians are in favor of finding out if a relative tests positive for a medically actionable genetic variant.

Study Links Evolution of Stony Coral Skeleton to Bicarbonate Transporter Gene

A PNAS paper focuses on a skeleton-related bicarbonate transporter gene introduced to stony coral ancestors by tandem duplication.

Hormone-Based Gene Therapy to Sterilize Domestic Cat

A new paper in Nature Communication suggests that gene therapy could be a safer alternative to spaying domestic cats.