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Serimmune COVID Antibody Epitope Mapping Service

Serimmune has launched a COVID antibody epitope mapping discovery service, which leverages the company's serum epitope repertoire analysis (SERA) technology. The service requires 100 ul of serum or plasma per sample, which Serimmune analyzes for IgG and/or IgM antibodies using its proprietary, 10-billion-member, random, bacterial peptide display library. The service provides a composite score of the antibody epitopes identified in each sample to those observed in cohorts of individuals with mild, moderate, and severe COVID-19 disease. It also provides single amino acid-resolution epitope data across the entire SARS-CoV-2 proteome for each sample and shows how it compares to a large cohort of pre-pandemic controls and SARS-COV-2 positive samples, the company said.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.