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SeqWell PlexWell Single-Cell Rapid Kit

SeqWell has launched its PlexWell Single-Cell Rapid Kit for the preparation of next-generations sequencing libraries for single-cell RNA sequencing. The kit improves upon the Smart-seq2 method by combining cDNA synthesis and amplification, and reducing the QC and normalization burden by 75 percent to achieve a single-day library prep workflow. This simplified approach can produce sequencing-ready, full-length transcriptome libraries from hundreds to thousands of sorted cells at a time, the company said. Other features include iterative barcoding and auto-normalization to create balanced library pools without the need for further sample or library normalization. The method has been optimized for low cDNA inputs to maintain library complexity, improve detection of low-abundance targets, and preserve variant and isoform information, the company said.

The Scan

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.

Seagull Microbiome Altered by Microplastic Exposure

The overall diversity and the composition at gut microbiome sites appear to coincide with microplastic exposure and ingestion in two wild bird species, according to a new Nature Ecology and Evolution study.

Study Traces Bladder Cancer Risk Contributors in Organ Transplant Recipients

In eLife, genome and transcriptome sequencing reveal mutation signatures, recurrent somatic mutations, and risky virus sequences in bladder cancers occurring in transplant recipients.

Genes Linked to White-Tailed Jackrabbits' Winter Coat Color Change

Climate change, the researchers noted in Science, may lead to camouflage mismatch and increase predation of white-tailed jackrabbits.