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Sengenics ImmuKyne Protein Array

Sengenics has launched the ImmuKyne protein array. The array is based on the company's KREX technology for discovering autoantibody biomarker signatures for predicting drug response and severe immune-related adverse events. The new product enables simultaneous screening of more than 300 immunomodulatory autoantigens comprising clinically significant protein classes that may be implicated in acute respiratory distress syndrome (ARDS), such as cytokines, chemokines, and interleukins. All proteins on ImmuKyne are full-length, correctly folded, and functional with both conformational and non-conformational epitopes preserved, which is critical as 90 percent of antibody binding sites are conformational in nature, the company said. The new tool is designed to further COVID-19 research by helping users understand whether autoantibodies play a role in progression to severe disease in COVID-19 patients.

The Scan

Open Pediatric Brain Tumor Atlas Team Introduces Genomic Data Collection, Analytical Tools

A study in Cell Genomics outlines open-source methods being used to analyze and translate whole-genome, exome, and RNA sequence data from the Pediatric Brain Tumor Atlas.

Neurological Outcomes Linked to Innate Immune Features After Cardiac Arrest

Researchers reporting in Med dig into immune features found a few hours after cardiac arrest that correspond with neurological outcomes.

Mouse Study Finds Circadian Rhythm-Related Gene Expression Changes Linked to Sleep Apnea

A paper in PLOS Biology reveals tissue-specific circadian rhythm and gene expression patterns in an intermittent hypoxia-based mouse model of obstructive sleep apnea.

Polygenic Risk Score to Predict Preeclampsia, Gestational Hypertension in Pregnant Women

Researchers in Nature Medicine provide new mechanistic insights into the development of hypertensive disorders of pregnancy, which may help develop therapeutics.