Skip to main content
Premium Trial:

Request an Annual Quote

Sema4 Centrellis Health Intelligence Platform

Sema4 has launched several genomic testing services and digital tools as part of its Centrellis Health Intelligence Platform. According to the firm, the tools provide a comprehensive approach to track a patient's cancer, and are based on 250x tumor coverage and 100x normal coverage across all genes.

The research use only tools include: Patient Journey, which provides an interactive timeline visualization of the patient's health journey and offers services such as diagnoses, treatments, and molecular profiles; Cohort Builder, which offers the ability to define groups of patients according to specific parameters such has stage, histology, and treatments to understand treatment patterns, identify appropriate clinical trials, and allow data-driven decisions about patient care; and VONC, which is an automated variant curation platform using a wide array of databases to support curation of genetic information at scale with clinical evidence to recommend therapy decisions.

Using 100 million reads, the services provide clinical data about a wide range of genomic variants, gene fusion and alternative splicing, tumor mutational burden, and microsatellite instability, the firm said. Researchers can perform the services using fresh frozen, paraffin-embedded, bone marrow, blood, or saliva samples.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.