Sciex QTRAP 6500+ LC-MS/MS System

Jun 09, 2016

Sciex has launched its QTrap 6500+ LC-MS/MS system. The new system delivers enhanced selectivity, without compromising MRM sensitivity. The QTRAP scan function of MS3 adds an additional level of mass filtering and the SelexION +ion mobility technology which has increased the ion transmission twofold in addition to eliminating isobaric background interferences in complex assays.

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Apr 25, 2018

HiberGene HG Pneumo/Meningo Combo

HiberGene has launched the HG Pneumo/Meningo Combo test for the rapid detection of meningococcal and pneumococccal meningitis. The loop-mediated isothermal amplification-based test covers up to 90 percent of cases of bacterial meningitis and provides results in less than one hour, compared to traditional microbiological methods which can take between 24 and 48 hours, the company said. Samples are incubated and read on HiberGene's HG Swift instrument. 

Apr 23, 2018

Swift Biosciences Accel-Amplicon Plus Cancer NGS Panels

Swift Biosciences has launched a suite of nine tumor-specific gene panels using its Accel-Amplicon technology. The Accel-Amplicon Plus Cancer NGS Panels enable detection of SNVs, copy number variants, and small indels. The company has launched four disease-focused panels for colorectal cancer, Lynch syndrome, lung cancer, and myeloid malignancies. In addition, it has also launched five gene panels, including one that focuses on comprehensive coverage of the TP53 gene, two BRCA-focused panels, an EGFR panel, and a pan-cancer panel. The panels are compatible with Illumina's sequencing instruments. Just 10 nanograms of sample input are required, and sample inputs can include DNA from formalin-fixed paraffin-embedded tissue and fine needle aspirates, as well as cell-free DNA. In addition, Swift has also launched its Swift Bioinformatics Resources, which include both open source and commercial bioinformatics tools to analyze NGS data.

Apr 23, 2018

Siemens Healthineers Fast Track Cycler, FastFinder Software

Fast Track Diagnostics, a Siemens Healthineers company, launched the Fast Track Cycler molecular testing platform and complementary FastFinder software at the European Congress of Clinical Microbiology and Infectious Diseases. 

The Fast Track cycler, for research use only, is a compact thermocycler weighing about 2 kg and measuring about 150mm3. It uses magnetic induction technology and does not require calibration. It also is equipped with Fast Track lyophilized PCR reagents, enabling users to simply add nucleic acid extracts to prepared tubes before placing them in the cycler. Up to 10 thermocyclers can be connected to one computer, and labs can use a range of one to 480 wells.

The FastFinder software, developed in collaboration with UgenTec, is a fully automated, CE IVD-marked real-time PCR interpretation platform compatible with all Fast Track multiplexed PCR kits. The software allows users to fully automate and standardize analysis of kits on the Thermo Fisher Scientific ABI 7500 and Roche LightCycler 480 PCR platforms. The software features statistical machine learning to accurately analyze all amplications curves, automatically recombining the results and processing them through an assay-specific decision tree to product a final result.

Apr 23, 2018

Cytena x.sight Single-Cell Printers

Cytena has launched three new single-cell printers, called c.sight, f.sight, and b.sight, that are part of its x.sight line of instruments. The c.sight instrument is designed for cell line development and single-cell genomics and can be operated outside a sterile bench. The f.sight device has two cameras, which can be controlled independently, to capture bright field and fluorescence signals simultaneously. In addition, it has an adjustable laser. The b.sight system enables the isolation of cells in the sub-micron range and printing single-cell bacteria. It has high-resolution optics and requires no staining or labeling of the cells. Cytena has also updated the software for all its single-cell printers, allowing them to be integrated into robotic platforms.

Apr 23, 2018

Qiagen QiaStat-Dx

Qiagen announced the European launch of the QiaStat-Dx platform during the European Congress of Clinical Microbiology and Infectious Diseases in Madrid. The company also launched the first test on the system, a 21-pathogen respiratory panel. QiaStat-Dx is a fully integrated and automated molecular testing system based on real-time PCR. It can detect up to 48 viral and bacterial targets simultaneously, enabled by microfluidic test casettes coupled with a six-wavelength optical sensor. There are also plans for the instrument to run immunoassays based on time-resolved fluorescence detection. The system, previously developed by StatDx as the DiagCore, received CE marking in January, prior to Qiagen's acquisition of StatDx.

Apr 19, 2018

Horizon Discovery Edit-R CRISPRa crRNA Libraries

Horizon Discovery announced the introduction of its Edit-R CRISPR arrayed crRNA (CRISPR RNA) libraries, which offer a tool for drug discovery, pathway analysis and disease progression studies. The libraries allow one-gene-per-well investigation by using high-content assays. The Edit-R CRISPRa portfolio also includes catalogue libraries for human and mouse gene families, including ubiquitin enzymes, transcription factors, and kinases, in addition to druggable gene targets and the whole human genome. The firm also noted that researchers will also be able to use bespoke collections to target a specialized gene target list.  

Apr 17, 2018

Bio-Techne RNAscope Assays

Bio-Techne announced the launch of its RNAscope VS Duplex kit, which delivers simultaneous in situ detection of two RNA species on an automated platform. The assay enables experiments including co-localization studies and gene expression profiling in specific cell types identifiable with known markers. The assay delivers improved specificity and sensitivity with clean signals, allowing researchers to pinpoint gene expression at single-molecule sensitivity.

In addition, Bio-Techne has launched the RNAScope VS Universal HRP and AP assays, which will integrate with Roche's mRNA universal software. The assays also have protocols that allow dual staining with immunohistochemistry or immunofluorescence.

Bio-Techne has also released the updated RNAscope 2.5 VS Reagent Kit-BROWN and -RED assays, which deliver permanent and intensified staining. The firm claims the assays are suitable for archiving and are ideal when anticipating low copy target gene expression.

Apr 17, 2018

Mission Bio Tapestri, Panels

Mission Bio has updated its Tapestri single-cell DNA analysis platform, which is now compatible with the Illumina HiSeq 2500 sequencer to allow for multiplexing and larger panels.

The company has also launched two new panels for myeloid disorders and for solid tumor profiling. The Tapestri Single-Cell DNA Myeloid Panel, designed to cover several myeloid disorders, targets single-nucleotide variants and indels in 47 genes. The Tapestri Single-Cell Tumor Hotspot Panel targets SNV and indel hotspot mutations across 50 genes involved in different solid tumor types and has been tested with breast, lung, prostate, and colorectal cancer nuclei from fresh-frozen tissue samples.

Apr 16, 2018

Thermo Fisher Scientific Oncomine Childhood Cancer Research Assay

Thermo Fisher Scientific has launched the Oncomine Childhood Cancer Research Assay, a next-generation sequencing panel developed in collaboration with Children's Hospital Los Angeles that specifically targets mutations associated with pediatric and young adult cancers. The assay combines specific mutations, gene amplifications, and fusions over 203 genes representing multiple gene classes, and 1,700 fusion transcripts in two DNA and two RNA pools. The assay is designed to integrate with the Ion Chef system for automated library preparation and amplification, as well as the Ion GeneStudio S5 system and Ion Reporter for bioinformatics and reporting.

Apr 16, 2018

True Health PlanTrue

True Health has launched the PlanTrue genetic carrier screening test. The next-generation sequencing test analyzes up to more than 80 genes associated with early-onset genetic conditions that are both prevalent and actionable. It comes in five versions that cover between three and 82 genetic conditions.

Apr 13, 2018

Fluidigm Maxpar Human Immune Monitoring Panel Kit

Fluidigm has launched the Maxpar Human Immune Monitoring Panel Kit for comprehensive immune cell profiling in cancer and immune-mediated diseases. Designed for use with the company's Helios CyTOF mass cytometry system, the new kit contains 29 metal-labeled antibodies and reagents designed and optimized for deep immune profiling of human peripheral blood mononuclear cells in a single tube. The panel biomarkers were selected in collaboration with pharmaceutical companies and academic institutions, and are optimized for routine high-parameter immune profiling, Fluidigm said. Multiple third-party data-analysis options are available to analyze results from the panel, including Cytobank and GemStone software. Verity Software House is providing free access to an enhanced version of GemStone software to customers who purchase the kit.

Apr 13, 2018

10x Genomics Chromium Single-Cell CNV Solution

10x Genomics has launched the Chromium Single-Cell CNV Solution, a scalable technology for rapid and parallel profiling of single-cell genomes. The solution is built on the firm's technology for generating cell beads and gel beads, and enables preparation of hundreds to thousands of single cells for CNV profiling within minutes on either the Chromium Controller or the Chromium Single-Cell Controller. It profiles the genomes of individual cells and can be used for applications such as revealing tumor heterogeneity, characterizing somatic mosaicism of neurons, and authenticating cell line identity and clonal purity. The product also further examines the clonal structure of cancer samples, including spatial distribution across tumor slices and longitudinal changes.

Apr 12, 2018

St. Jude Cloud

St. Jude Children's Research Hospital, in partnership with DNANexus and Microsoft, has introduced St. Jude Cloud, a public repository of genomics data on pediatric cancer. The St. Jude Cloud platform, which includes free analytics and visualization tools, contains more than 5,000 anonymized whole-genome sequences and 1,200 RNA sequences from young cancer patients. Researchers also are able to upload their own data for analysis and visualization on the cloud-based platform.

Apr 12, 2018

Qiagen AdnaTest ProstateCancerPanel AR-V7 and LungCancer Kits

Qiagen this week launched the AdnaTest ProstateCancerPanel AR-V7 and AdnaTest LungCancer kits at the American Association for Cancer Research annual meeting.

AdnaTest ProstateCancerPanel AR-V7 detects the androgen receptor splice variant 7 in circulating tumor cells (CTCs) of prostate tumor origin isolated from blood samples to investigate potential resistance to drugs for advanced prostate cancer. With an exclusive worldwide license from Johns Hopkins University for nucleic acid detection of the AR-V7 biomarker for diagnostic use, Qiagen is now launching the test for research use.

AdnaTest LungCancer provides insights into the molecular mechanisms of lung cancer through highly specific selection of CTCs, including stem cell-like cells implicated in cancer growth and epithelial-mesenchymal transition, an important marker of cancer therapy resistance. A proprietary set of antibodies provides sensitive detection of lung cancer-associated targets through reverse-transcriptase PCR, and the open system enables users to add targets of interest.

Apr 12, 2018

Fluidigm Advanta CFTR NGS Library Prep Assay

Fluidigm has launched the Advanta CFTR NGS Library Prep Assay, a next-generation sequencing library prep workflow for sequencing of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Developed for use with the company's Juno system, the assay automates target enrichment of CFTR variants from each of the gene's 27 exons and selected intronic regions using microfluidic technology. The assay can produce 48 to 1,500 or more NGS libraries each week from DNA derived from blood, saliva, or buccal swabs. Each integrated microfluidic circuit features open inlets to simplify the addition of new assay over time, the company said.

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