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Samplix Xdrop Services

Danish company Samplix has launched a comprehensive service program granting laboratories access to its Xdrop technology for complex genomic research including gap closing, sequencing of repeat elements, viral insertion site detection, revealing unintended CRISPR edits, and more. Xdrop enriches genomic regions longer than 100 kb from as little as 1 ng of human genomic DNA and with single-molecule resolution. It requires knowledge of only a short sequence within or flanking the target region for efficient target selection. Following targeted selection, multiple displacement amplification is applied to single DNA molecules compartmentalized in droplets. This ensures unbiased amplification of large DNA fragments that are representative of the target variation in the original sample. The output is ready for any short-read or long-read sequencing platform, the company said.

The Scan

For Better Odds

Bloomberg reports that a child has been born following polygenic risk score screening as an embryo.

Booster Decision Expected

The New York Times reports the US Food and Drug Administration is expected to authorize a booster dose of the Pfizer-BioNTech SARS-CoV-2 vaccine this week for individuals over 65 or at high risk.

Snipping HIV Out

The Philadelphia Inquirer reports Temple University researchers are to test a gene-editing approach for treating HIV.

PLOS Papers on Cancer Risk Scores, Typhoid Fever in Colombia, Streptococcus Protection

In PLOS this week: application of cancer polygenic risk scores across ancestries, genetic diversity of typhoid fever-causing Salmonella, and more.