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Sage Science SageHLS Platform

Sage Science has launched SageHLS, a platform designed to extract and purify extremely large DNA fragments directly from bacterial and tissue cultures, blood samples, or other cell sources. SageHLS can purify DNA into fragments ranging from 50 kilobases to 2 megabases, providing the long fragments needed for resolving haplotypes, structural variants, and other large or linkled genomic elements. For most samples, SageHLS can recover at least a microgram of DNA, a sufficient volume for common genome applications. Users can currently perform traditional library prep after purification on the platform, but later versions will directly incorporate this step for a more streamlined workflow, Sage Science said.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.