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Sage Bionetworks Agora Platform

Sage Bionetworks has launched the Agora platform, a web-based tool that allows researchers to explore curated genomic analyses of Alzheimer's disease. The analyses resulted from the Accelerating Medicines Partnership – Alzheimer's Disease (AMP-AD) Target Discovery and Preclinical Validation Project, a public-private partnership led by the National Institute on Aging and managed by the Foundation for the NIH (FNIH). Through the Agora portal, which will be frequently updated, the analyses are now available to researchers outside the AMP-AD consortium. The initial release includes differential expression and co-expression network meta-analyses across four human RNA sequence data sets. Future releases will include human proteomic and metabolomic analyses, comparative evaluations of disease signatures across species, and druggability and tractability information to guide the selection of targets for early drug discovery.

The Scan

Genes Linked to White-Tailed Jackrabbits' Winter Coat Color Change

Climate change, the researchers noted in Science, may lead to camouflage mismatch and increase predation of white-tailed jackrabbits.

Adenine Base Editor Targets SCID Mutation in New Study

Researchers from the University of California, Los Angeles, report in Cell that adenine base editing was able to produce functional T lymphocytes in a model of severe combined immune deficiency.

Researchers Find Gene Affecting Alkaline Sensitivity in Plants

Researchers from the Chinese Academy of Science have found a locus affecting alkaline-salinity sensitivity, which could aid in efforts to improve crop productivity, as they report in Science.

International Team Proposes Checklist for Returning Genomic Research Results

Researchers in the European Journal of Human Genetics present a checklist to guide the return of genomic research results to study participants.