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Roche NimbleGen SeqCap EZ MedExome Target Enrichment Kit

Roche NimbleGen has globally launched the SeqCap EZ MedExome target enrichment kit, a comprehensive whole-exome sequencing solution designed to increase the discovery and detection of human genetic variants associated with disease while reducing sequencing costs. The design targets the genome assembly GRCh38/hg38 (coordinates for hg19 annotation are also available) with comprehensive sequencing coverage of medically relevant and protein-coding regions. The product has been extensively optimized in design, empirical rebalancing, and manufacturing to increase coverage in hard-to-sequence regions for a more uniform and complete exome, Roche NimbleGen noted. SeqCap EZ MedExome produces greater than 85 percent on-target rate, and demonstrates high uniformity across the targeted region with about 98 percent sensitivity for SNP detection and greater than 99 percent specificity for SNP allele classification, according to Roche.

The Scan

Support for Moderna Booster

An FDA advisory committee supports authorizing a booster for Moderna's SARS-CoV-2 vaccine, CNN reports.

Testing at UK Lab Suspended

SARS-CoV-2 testing at a UK lab has been suspended following a number of false negative results.

J&J CSO to Step Down

The Wall Street Journal reports that Paul Stoffels will be stepping down as chief scientific officer at Johnson & Johnson by the end of the year.

Science Papers Present Proteo-Genomic Map of Human Health, Brain Tumor Target, Tool to Infer CNVs

In Science this week: gene-protein-disease map, epigenomic and transcriptomic approach highlights potential therapeutic target for gliomas, and more