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Roche Cobas SARS-CoV-2 Variant Set 1 Test

Roche has launched its Cobas SARS-CoV-2 Variant Set 1 Test for research use only to detect mutations in virus variants associated with increased human-to-human transmission. It detects and differentiates three mutations found in the UK B.1.1.7, South Africa B.1.351, and Brazil P.1 variants. Mutations E484K, N501Y, and del 69-70 for these variants are found in the spike protein and may be linked to increased disease transmissibility. 

The RT-PCR test runs on the high-throughput Cobas 6800/8800 systems and contains the necessary primers and probes in the 384-test cassette. 

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.