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Qlucore's Omics Explorer

Feb 11, 2015

Qlucore has released Omics Explorer 3.1, the latest version of its advanced data analysis software. This release includes a well-defined open interface to R that gives users access to a broader range of statistical tests and a more flexible colour scale.

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May 29, 2020

Bruker MALDI-2 Source for TimsTOF Flex; 4D Proteomics Workflows

Bruker has launched the MALDI-2 post-ionization source as an option on its TimsTOF Flex ESI/MALDI mass spectrometer. The new technology can offer one or two orders of magnitude higher sensitivity for many small molecules and lipids, increasing the range of applications of MALDI mass spectrometry and imaging. MALDI-2 requires a second laser (266 nm) fired orthogonally into the expanding MALDI plume that is generated by Bruker's proprietary primary SmartBeam 3D (355 nm) laser. An optimized FlexMatrix formulation is recommended for MALDI-2, the company said.

Bruker has also launched TIMS/PASEF-enabled 4D proteomics methods that leverage the large-scale, real-time availability of accurate collision cross sections for tens of thousands of measured peptides per 4D nanoLC-CCS-MS/MS run. These new methods and software include prm-PASEF, short-gradient dia-PASEF, MOMA, and "run and done" proteomics using a novel GPU-based real-time search engine. The new innovations enable enhanced peptide, protein, and PTM identification; sustained, ultra-high sensitivity LFQ performance; and truly high-throughput methods for 4D proteomics, 4D lipidomics, and 4D metabolomics on the TimsTOF Pro platform, Bruker said.

May 29, 2020

Qiagen QCI Interpret One Software; QiaSeq Pan-Cancer Multimodal Panel; and QiaSeq Targeted Methyl Panel

Qiagen launched multiple new products for genomic variation analysis in connection with the virtual 2020 American Society of Clinical Oncology annual meeting.

Qiagen's new QCI Interpret One software joins the company's Qiagen Clinical Insights portfolio, and provides variant- and disease-specific evidence for every variant in any somatic panel, backing each classification with the latest peer-reviewed publications, oncologist-reviewed interpretation summaries, and "expert second opinions," the company said. The new product combines the former N-f-One interpretation summaries with Qiagen's QCI Interpret structured variant interpretation database, the company noted.

Meanwhile, the new QiaSeq Pan-cancer Multimodal panel enables the consolidation of two separate next-generation sequencing-based DNA and RNA variant profiling workflows into one. It also enables scalable and parallel integration of up to thousands of targets in one enrichment step in a single tube, Qiagen said. Ideal for comprehensive genomic profiling and biomarker discovery, this 1.44-Mb panel consists of more than 600 target genes and fusions involved in the onset, progression, and treatment response across different cancer types, as well as microsatellite instability markers. Qiagen said the panel has a one-day turnaround time.

Finally, the new QiaSeq Targeted Methyl panels provide NGS-based targeted methylation analysis with a one-day turnaround time using the company's proprietary single primer extension technology. Qiagen offers predesigned panels for breast and colorectal cancer, as well as rapid, online custom design capabilities to create tailored panels for customer-specific applications. The company expects to launch immuno-oncology and T-cell infiltration applications later in 2020.

May 29, 2020

Mission Bio Tapestri Designer Extended Applications

Mission Bio has released extended capabilities for its Tapestri Designer automated, cloud-based tool for designing targeted single-cell DNA custom panels. The tool now includes applications for mouse genomes and CRISPR editing, reducing design time for custom panels from weeks to just minutes to help accelerate cell and gene therapy, the company said. 

With the new CRISPR applications, researchers can measure zygosity, co-occurrence of multiple edits including on- and off-target events, and rare cell populations, providing the information necessary to optimize editing systems and use them safely. As part of the mouse genome compatibility feature, mouse single-cell custom DNA panels are now available. Mission Bio also said its design experts are on hand to support customers with unique and novel custom panel needs for single-cell DNA or multi-omics panels. 

May 28, 2020

Analytik Jena Biometra TRobot II and qTOWER³ Auto Thermal Cyclers

Jena, Germany-based life science firm Analytik Jena has introduced two new thermal cyclers. The Biometra TRobot II is a small footprint PCR module that can be used to save space in a robotic setup, while the qTOWER³ Auto is a qPCR thermal cycler useful for fully automated qPCR applications.

May 28, 2020

Swift Biosciences Normalase Amplicon Panel SARS-CoV-2 Kit

Swift Biosciences has released a new sample preparation kit for low viral titer SARS-CoV-2 specimens.

The Swift Normalase Amplicon Panel SARS-CoV-2 kit targets the full coronavirus genome in a single-tube reaction. The two-round PCR workflow takes as little as two hours and produces multiplexed, sequencing-ready libraries. The kit is intended for use in research or pathogen surveillance.

May 27, 2020

Thermo Fisher Scientific Orbitrap Exploris Mass Spectrometers, Proteome Discoverer 2.5 Software, Xcalibur 4.4 Software

Thermo Fisher Scientific has released the Thermo Scientific Orbitrap Exploris 240 and 120 mass spectrometers. The Exploris 240 is designed for researchers working in proteomics, metabolomics, biopharmaceutical characterization, and small-molecule analysis. It promises discovery and identification with increased accuracy and offers operational simplicity and streamlined time-to-result. The system delivers mass accuracy, sensitivity, and resolving power across a wide dynamic range. It offers positive/negative-mode switching for comprehensive sample coverage and fast scan speeds.

The Exploris 120 offers internal calibration for consistent data quality and decision making. It features fast scanning modes and rapid polarity switching for comprehensive sample coverage and increased productivity.

In addition, the company launched the Thermo Scientific Proteome Discoverer 2.5 software for higher-confidence peptide identification, more accurate quantification, and higher-throughput data analysis of proteomics data. It uses deep learning to more accurately predict fragmentation mass spectra, facilitated by a Prosit-derived neural network licensed from bioinformatics firm and collaborator MSAID. It also provides more confident results in applications that require large search spaces, such as human leukocyte antigen (HLA) or metaproteomic analyses. In addition, the new release includes an enrichment service that helps provide biological meaning for differential analyses and support of targeted workflows. It also has tools to help deploy Thermo Scientific SureQuant Targeted Mass Spectrometry Assay Kits and custom SureQuant IS-triggered acquisition assays in new proteomics labs.

The company also launched the Thermo Scientific Xcalibur 4.4 software, which brings the AcquireX intelligent data acquisition workflow to Thermo Scientific Orbitrap Exploris mass spec platform users. It enables the fully automated collection of high-quality MS/MS data on components of interest in a sample and reduces manual input and the need for repeat runs.

May 22, 2020

Genedata Imagence 2.0

Genedata has released Genedata Imagence 2.0, the latest version of its enterprise software high-content screening image analysis. The new version offers full end-to-end automation, reducing the time spent on image analysis by an order of magnitude. It enables the analysis of complex phenotypic assay formats without extensive expert input, and the transfer of gained knowledge to new experimental setups. It has also been further optimized for use of distributed computing resources. In particular, the parallelization of image analysis steps results in massive time and cost savings, the company said. Similar to other components of the Genedata Biopharma Platform, the new software can be deployed using on-demand cloud computing service providers like Amazon Web Services.

May 20, 2020

10x Genomics Targeted Gene Expression Solution

10x Genomics has launched its Targeted Gene Expression Solution for single-cell sequencing.

The firm is offering kits for predesigned gene panels relevant to cancer, immunology, neuroscience, and drug targeting applications, with the option for customization.

May 19, 2020

Aalto Bio Reagents Recombinant SARS-CoV-2 Spike Proteins

Dublin-based Aalto Bio Reagents has released a range of recombinant SARS-CoV-2 spike (S) proteins for diagnostic test manufacturers, vaccine developers, and researchers globally. The S protein is the main antigenic component that is responsible for inducing host immune responses and neutralizing antibodies, making it the principal focus of therapeutic and vaccine design for COVID-19. When used solely or in combination with Aalto's new insect-derived nucleocapsid protein (N), the company's S1-S2 chimeric glycoprotein has demonstrated excellent reactivity in ELISA for the detection of IgA, IgG and IgM antibodies against SARS-CoV-2, the company said.

May 19, 2020

Thermo Fisher Scientific Invitrogen RiboMinus Bacteria 2.0 Transcriptome Isolation Kit

Thermo Fisher Scientific has released the Invitrogen RiboMinus Bacteria 2.0 Transcriptome Isolation Kit for the probe-based depletion of ribosomal RNA from bacteria. The kit, which can be automated on Thermo Fisher KingFisher instruments, uses a novel magnetic bead-based purification technology to selectively deplete rRNA transcripts from total RNA. It now includes 5S targets and more than 100 probe designs to yield improved rRNA depletion and can be utilized with RNA from a wide variety of species.

May 19, 2020

Oxford Immunotec T-Spot Discovery SARS-CoV-2 RUO Kit

Oxford Immunotec Global has launched the T-Spot Discovery SARS-CoV-2 test kit for research use only. The kit builds on its experience with tuberculosis diagnosis and the assessment of the immune response to cytomegalovirus infections in transplant patients. Using the company's established T-Spot technology, the kit interrogates the immune system's T-cell response and will enable research into the measurement of the strength of that response to SARS-CoV-2, Oxford Immunotec said.

May 14, 2020

EnGenome eVai Variant Interpretation/Genomenon Mastermind Genomic Search Engine

Genomenon's Mastermind Genomic Search Engine has been integrated into the eVai Variant Interpretation platform from EnGenome, Genomenon said. eVai users can now preview the number of published articles related to their search and easily link out to view the evidence in Mastermind. By combining artificial intelligence with ACMG-AMP guidelines, eVai classifies and prioritizes every genomic variant for pathogenicity, suggesting all possible related genetic diagnoses. Mastermind has indexed more than 7.5 million full-text articles and 1.5 million supplemental data sets, and covers more than 6.1 million variants found in the medical literature.

May 14, 2020

Biocept Target Selector BRAF RUO Kits

Biocept has launched a Target Selector research-use-only molecular assay for the detection of BRAF mutations in both formalin-fixed, paraffin-embedded samples and blood samples. The kits use the company's Switch-Blocker technology to enrich the specimen for mutations of interest, resulting in ultra-high assay sensitivity and specificity. Biocept said that in general, its Target Selector kits can detect mutations of interest in circulating tumor DNA at a level of one mutant copy in 10,000 wildtype molecules. The assays can be used with a variety of analytical platforms including qPCR, Sanger sequencing, next generation sequencing, microarrays, and mass spectrometry. The new BRAF kit complements the company's previously launched EGFR mutation-detection assay.

May 13, 2020

ZeptoMetrix NATSARS(CoV-2) Quality Controls

ZeptoMetrix has launched its ready-to-use NATSARS(CoV-2) molecular quality controls, including its NATtrol SARS-CoV-2 Positive Control and NATtrol SARS-CoV-2 Negative Control. The firm said the tools are formulated with purified intact viral particles chemically modified to render them non-infectious and refrigerator stable. ZeptoMetrix said the products will provide laboratories external run controls to help establish the reliability of COVID-19 testing.

May 12, 2020

Beckman Coulter Life Sciences RNAdvance Viral XP

Beckman Coulter Life Sciences announced the launch of its new RNA extraction kit, RNAdvance Viral XP. The kit is validated for use in infectious disease and real-time PCR virus research and is intended for use in high-throughput settings to extract viral RNA from swab samples, the firm said. After it has been extracted, the RNA is used in qRT-PCR kits to determine whether the virus is present. Danaher subsidiary Beckman Coulter worked with next-generation sequencing company iRepertoire to develop the kit's method, which iRepertoire then independently validated. 

President Donald Trump announced the US would be leaving the World Health Organization, NBC News reports.

A study of Great Danes homes in on a genomic region linked to fearfulness.

CDC head says a new analysis indicates earlier testing wouldn't have caught viral spread, NPR reports.

In PLOS this week: gene expression and epigenetics of Indonesian populations, hookworm parasite secretome, and more.