Qlucore's Omics Explorer | GenomeWeb

Qlucore's Omics Explorer

Feb 11, 2015

Qlucore has released Omics Explorer 3.1, the latest version of its advanced data analysis software. This release includes a well-defined open interface to R that gives users access to a broader range of statistical tests and a more flexible colour scale.

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Mar 30, 2017

FlowJo SeqGeq

FlowJo has launched SeqGeq, a platform-agnostic desktop application for analysis of single-cell omics data. It offers tools to identify subpopulations of cells based on a variety of genes and synthetic parameters, to compare clusters and identify differentially-expressed genes or pathways of interest, and to generate publication-ready heatmaps and figures using a drag-and-drop layout editor. The application accepts a variety of data types, including scRNA-seq, RNA-Seq, andmicroarray data.

Mar 30, 2017

NanoString nCounter Enhancement Kits and Gene Expression Panels

NanoString has announced a new nCounter mRNA amplification kit, a universal cell capture kit, and two new nCounter assays. The nCounter Low RNA Input Kit employs multiplexed target enrichment to linearly amplify mRNA transcripts, enabling gene expression analysis with sample inputs between 1 to 10 nanograms. The kit is compatible with both pre-defined and custom panels. The Intracellular Compatible Universal Cell Capture Kit enables researchers to use the nCounter Vantage RNA:Protein Immune Cell Signaling Assay with as few as 20,000 cells. NanoString is also releasing two new assays. The RNA MAPK-PI3K Pathways panel provides a curated gene set to measure transcriptional activity of those pathways. The firm is also offering a gene expression panel for myeloid cell innate immune response in humans or mice, developed in partnership with Lisa Coussens of Oregon Health and Sciences University.

Mar 30, 2017

IncellDx OncoTect IO Lung Kit

IncellDx has launched the CE-IVD marked OncoTect iO Lung kit, a flow cytometry based assay. The kit incorporates a non-enzymatic single cell tissue homogenization process, using incellPREP, for unfixed tumor biopsy samples, labels cell suspensions with antibodies to CD45, CD8, CD3, PD-L1, stained with a Cell Cycle Dye, and then analyzes samples via flow cytometry. This allows researchers to enumerate the immune and tumor cell populations, quantify the percent of cells expressing PD-L1, and quantify PD-L1 receptor expression across each cell type. The assay also quantifies tumor infiltrating lymphocytes and quantification of PD-L1 expression at various stages of the tumor cell cycle.

Mar 30, 2017

Invitae Exome Test

Invitae has launched an exome sequencing and interpretation service, called the Boosted Exome. Invitae believes this testing will be particularly useful in diagnosing rare pediatric diseases or providing insights into complex cases where doctors suspect a genetic disease but it's unclear which gene or alteration is involved. According to the company, the test analyzes 3-5 mL whole blood (but can alternatively analyze saliva) and uses next-generation sequencing capture technology with boosted coverage of medically relevant genes. The exome test, with the capability to analyze up to 20,000 protein coding genes, also uses custom bioinformatics solutions for variant analysis, a phenotyping tool to prioritize relevant genes for analysis, and analytical solutions to identify other genes through inheritance patterns or functional impact. The data are interpreted by board-certified geneticists, and results are returned within six-to-eight weeks. Parents have access to genetic counseling and doctors can confer with clinical consultants. Proband only exome testing costs $2,500, while additional testing of one or both biological parents brings the cost up to $4,500.

Mar 29, 2017

Genomenon Mastermind Panel Design Service

Genomenon has launched its Mastermind Panel Design Service. The service provides researchers with genes and variants associated with a particular disease by using the company's Mastermind database to mine for disease-gene-variant relationships extracted from primary medical literature, the company said. Using that information, Genomenon researchers can help consumers curate a panel from candidate genes, exons, and variants supported by literature citation.

Mar 29, 2017

GeneNews BreastSentry

GeneNews has launched BreastSentry, a new risk stratification test for breast cancer. The company will offer the test in its Virginia-based clinical reference lab. The test measures the fasting plasma levels of two biomarkers in the blood, proneurotensin and proenkephalin, which are highly predictive of a woman's risk for developing breast cancer, the company said. It is intended for use in average risk women who have no family history of breast cancer, especially for women who have dense breast tissue, to better evaluate when patients may require further screening.

Mar 29, 2017

Empirical Bioscience Agarose Gel Extraction Kit

Empirical Bioscience has launched the Agarose Gel Extraction kit. The kit includes an extraction buffer, activation buffer, washing buffer, elution buffer, spin columns, and collection tubes. It allows efficient DNA purification from agarose gels and provides maximum recovery of DNA from 100bp to 10kb. It also removes primer-dimers, primers, nucleotides, proteins, salt, agarose, ethidium bromide, and other impurities, the company said.

Mar 29, 2017

Cellecta Driver-Map Human Genome-Wide Gene Expression Profiling Kit

Cellecta has launched its Driver-Map Human Genome-Wide Gene Expression Profiling kit. It is a multiplexed RT-PCR-based assay designed to easily provide a molecular "snapshot" of protein-coding genes from complex samples, starting from as little as 10 pg of total RNA. The assay includes a complete set of gene-specific and PCR-NGS primers, buggers, spike-in ERCC, positive control RNAs, and all other reagents required to profile 24 samples, the company said. The kit allows researchers to selectively amplify the 19,000 known annotated human transcripts, use experimentally validated GCA-rich primers for comprehensive view of the spectrum of gene regulation, and have exacting RNA quality control.

Mar 28, 2017

Personal Genome Diagnostics PlasmaSELECT 64

Personal Genome Diagnostics has launched the PlasmaSELECT 64, a targeted panel for pan-cancer tumor profiling that incorporates proprietary technologies and bioinformatics. It is the first liquid biopsy tumor profiling assay to test for microsatellite instability status, a biomarker for tumor mutational load that helps identify cancer patients who might benefit from checkpoint inhibitors and other immuno-oncology cancer therapies. The panel includes 15 unique biomarkers, 11 of which are associated with active clinical trials. The panel is enabled by the company's proprietary DNA extraction and sample preparation methods, which accommodate low-abundance cell-free DNA samples, as well as hybrid-capture processing in combination with high-coverage, next-generation sequencing. The company's proprietary VariantDx computational algorithms enable discrimination of sequencing artifacts and errors from bona-fide mutations.

Mar 28, 2017

SGI-DNA NGS Library Construction Kits

SGI-DNA has launched Next-Generation Sequencing Library Construction Kits for its BioXP 3200 system. The new kits allow scientists to prepare DNA samples for NGS applications on the BioXp 3200, which uses the Gibson assembly method, automating essential steps in reading and writing DNA on a single compact workstation.

Mar 28, 2017

Bruker Avance Neo NMR Research Platform

Bruker has launched its  Avance Neo NMR Research Platform. The next-generation NMR electronics console surpasses the firm's previous Avance III HD, offering even faster control, improved dynamic range, and enhanced flexibility and scalability, Bruker said. New transceiver architecture enables each channel of the Avance Neo to operate as a fully functional spectrometer. According to the company, the new system also allows NMR pulse programs developed on previous Avance platforms, as well as new multi-receive pulse sequencing and experimental design capabilities never before available in the field.

Mar 27, 2017

Bioline JetSeq DNA Quantification Kits

Bioline, a wholly-owned subsidiary of Meridian Bioscience, has launched the JetSeq Library Quantification Kit. The qPCR-based assay provides fast, accurate, and sensitive quantification of adaptor-ligated DNA fragments during the preparation of Illumina-compatible NGS libraries. The kit relies on SYBR Green for detection and contains all of the components required for library quantification, including dilution buffer, P5 and P7 adapter primers, and six pre-diluted DNA standards to minimize pipetting, reduce variability, and increase reproducibility. It has sufficient standards to quantify eighteen libraries on individual plates or up to seventy-six libraries when multiple libraries are quantified on the same plate.

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10X Genomics Chromium Single Cell V(D)J Solution

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Mar 24, 2017

Cepheid Xpert MTB/RIF Ultra

Cepheid, Rutgers New Jersey Medical School and FIND launched the Xpert MTB/RIF Ultra test for diagnosing tuberculosis and resistance to the antibiotic rifampicin. The test is the second generation of Cepheid's Xpert MTB/RIF test, which was launched in 2010. The Ultra was redesigned to increase analytical sensitivity more than tenfold and to improve the detection of mutations associated with rifampin resistance, FIND said.

The World Health Organization recommends the new test be used as an alternative to the older test in all settings, but a WHO expert group also noted that because of the increased sensitivity, use of the Ultra can result in higher numbers of false positives, compared to Expert MTB/RIF. As a result, the group said more discussion is needed on implementing the new test and balancing increased sensitivity with decreased specificity in different settings.

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Seraseq Inherited Cancer DNA Mix Reference Material

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