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Qlucore Omics Explorer V3.6

Qlucore has released version 3.6 of its Qlucore Omics Explorer (QOE) data analysis software. QOE provides fast, simple, visual analysis of measured data from a wide range of sources and instruments. It ships in a base module with an option to add a module with extensive functionality for next-generation sequencing data analysis. The program integrates well with workflows and through the Python-based template functionality it is possible to control the program through a script and to configure well-defined analysis steps. V3.6 has several new features including the direct import of single-cell data and improved survival calculations using hazard ratios; the addition of one more classifier method (gradient-boosted decision trees) in the machine learning module; and an expanded suite of standard templates, including templates for direct import of single-cell data from 10x Genomics and one for direct download from The Cancer Genome Atlas.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.