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Qiagen QiaSymphony PowerFecal Pro DNA Kit

Jan 09, 2020

Qiagen has launched the QiaSymphony PowerFecal Pro DNA Kit for the isolation of microbial genomic DNA from stool and soil using the QiaSymphony automation platform. The new kit enables automated, time-saving, standardized extraction of inhibitor-free DNA from stool and soil samples for metagenomic analysis, and is designed for 192 samples with continuous loading of 24-sample batches. Qiagen said that its new PowerBead Pro tubes are included in the kit for homogenization. The beads and optimized chemistry enable more efficient lysis of bacteria and fungi.

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Feb 25, 2021

Twist Bioscience NGS Methylation Detection System

Twist Bioscience has launched the Twist NGS Sequencing Methylation Detection system, a sample preparation and target enrichment solution for identifying methylated regions in the human genome.

The system uses EM-seq from New England Biolabs, an enzyme-based alternative to traditional bisulfite sequencing methods that enables preparation of enzymatically converted libraries. The system also includes Twist methylation enhancer, universal blocker and FastHyb, and custom methylation panels that include DNA probes to capture all four potential sequences at a given site: methylated, unmethylated, sense and antisense.

The products can be used in liquid biopsy cancer analysis and epigenetic studies.

Feb 25, 2021

New England Biolabs Artic Products for SARS-CoV-2 Sequencing

New England Biolabs has launched three kits based on the Artic Network protocols for multiplexed amplicon-based sequencing of viral RNA: NEBNext Artic SARS-CoV-2 Library Prep Kit and NEBNext ARTIC SARS-CoV-2 FS Library Prep Kit, both for Illumina sequencing; and NEBNext Artic SARS-CoV-2 Companion Kit for Oxford Nanopore Technologies sequencing.

The Artic network is an international research consortium that has developed protocols for the epidemiological monitoring of viral genomes to provide insights into virus evolution and transmission. All three NEBNext Artic SARS-CoV-2 kits yield uniform, ample amplicons from gRNA across a wide copy number range, and use the same RT step for all inputs, NEB said. The two kits for Illumina sequencers provide options for library insert size and downstream sequencing parameters.

Feb 24, 2021

Promega LMR MSI Analysis System

Promega has launched its LMR MSI Analysis system, a PCR-based research tool with novel markers for detecting microsatellite instability. The panel consists of eight total markers: four gold-standard markers (BAT-25, BAT-26, MONO-27, and NR-21) and four novel long mononucleotide repeat markers (BAT-52, BAT-56, BAT-59, and BAT-60). According to the company combining these marker sets expands MSI detection ability in difficult samples while maintaining overlap with data gathered using traditional markers. Promega said that the assay has been optimized to enable strong and balanced amplification even from degraded samples such as formalin-fixed, paraffin-embedded tissue.

Feb 22, 2021

NanoString Technologies Whole Transcriptome Atlas

NanoString Technologies has announced the commercial availability of its Whole Transcriptome Atlas (WTA) for research using human tissue on the GeoMx digital spatial profiler.

The WTA provides an unbiased, spatial view of all protein-coding genes and is designed for next-generation sequencing readout on Illumina sequencers. It works with formalin-fixed paraffin-embedded or fresh frozen samples.

The company also announced that it is launching the WTA for mouse tissue through its GeoMx technology access program.

Feb 19, 2021

Guardant Health Guardant Reveal

Guardant Health has launched Guardant Reveal, a blood-based liquid biopsy test for the detection of residual and recurrent disease in cancer patients. Intended initially for the early-stage colorectal cancer space, the assay detects circulating tumor DNA in patients' blood to identify those with residual disease who may benefit most from adjuvant therapy and/or detect the first signs of a recurrence. Results are returned in as little as seven days without the need for a tissue biopsy.

Feb 18, 2021

Parse Biosciences Single-Cell Whole Transcriptome Kit

Parse Biosciences, formerly known as Split Biosciences, has launched its Single-Cell Whole Transcriptome kit in North America.

The kit, which requires only basic lab equipment, enables single-cell transcriptomics for up to 100,000 cells or nuclei across 48 samples. Samples can be fixed for up to six months prior to barcoding and sequencing. The method is based on the split-pool ligation-based transcriptome sequencing (SPLiT-seq) method. Customers purchasing the kit will receive access to the Parse computational pipeline, an out-of-the box software tool that can be run locally.

Feb 17, 2021

Menarini Silicon Biosystems CellMag Product Line

Menarini Silicon Biosystems has launched its CellMag product line. The line includes the CTC Epithelial Cell kit for ferrofluid-based EpCAM-positive circulating tumor cell enrichment, a magnetic tool, and consumables. The firm believes the product line will help researchers conduct specific, established, and standardized immunomagnetic enrichment and staining of CTCs in peripheral blood. After positive selection of enriched cells, performed by capturing cells through ferrofluids labeled with antibodies targeting specific antigens, the staining procedure delivers cells that are ready for enumeration, isolation, and downstream analysis. Menarini said the CellMag line provides researchers with a manual system using the same ferrofluid technology offered by its CellSearch system.

Feb 17, 2021

CellPort Software Cell Culture Suite

CellPort Software has launched the CellPort Cell Culture Suite, a cloud-based software-as-a-service product for cell culture and cell banking. The product is a secure, compliant application suite designed to manage all lab workflows, activities, equipment, materials, personnel, data/calculations, locations, and projects for cell culture and cell banking.

Feb 16, 2021

Verogen ForenSeq Kintelligence Kit

Forensic genomics firm Verogen has launched the ForenSeq Kintelligence Kit for genetic genealogy. The next-generation sequencing-based workflow runs on the Illumina MiSeq FGx system and targets 10,230 SNPs curated for forensics while minimizing medically informative markers. It is also integrated with GEDmatch PRO genealogy database.

Feb 12, 2021

Active Motif Hi-C Epigenetic Service

Active Motif has launched an end-to-end Hi-C service built on Arima Genomics' Hi-C kits. Hi-C is used by the research community and multiple large consortia such as ENCODE and 4D Nucleome to investigate how genome folding and misfolding impacts gene accessibility, regulation, and expression, and its impact on disease states. Under an agreement with Arima, Active is launching its Active Motif Epigenetic Service to serve academic, pharma, and clinical researchers.

Feb 12, 2021

SeqWell PlexWell Single-Cell Rapid Kit

SeqWell has launched its PlexWell Single-Cell Rapid Kit for the preparation of next-generations sequencing libraries for single-cell RNA sequencing. The kit improves upon the Smart-seq2 method by combining cDNA synthesis and amplification, and reducing the QC and normalization burden by 75 percent to achieve a single-day library prep workflow. This simplified approach can produce sequencing-ready, full-length transcriptome libraries from hundreds to thousands of sorted cells at a time, the company said. Other features include iterative barcoding and auto-normalization to create balanced library pools without the need for further sample or library normalization. The method has been optimized for low cDNA inputs to maintain library complexity, improve detection of low-abundance targets, and preserve variant and isoform information, the company said.

Feb 12, 2021

Genomind GenMed Pro Smarter Precision Gene-Drug Interaction Software

Genomind has launched its GenMed Pro Smarter Precision Gene-Drug Interaction Software, medication management software designed to work in tandem with the company's Genomind Professional PGx Express pharmacogenetic test. GenMed Pro covers the most commonly prescribed medications for the top healthcare conditions. These medications are assesses with key genes that can impact a patient's metabolism, absorption, and sensitivity. The software will be available at no additional cost to healthcare providers who register for Genomind's Clinician Portal.

Feb 11, 2021

Zymo Research COVID-19 Variant Sequencing Service

Zymo Research has launched its COVID-19 Variant Sequencing Service. The workflow consists of sample collection from testing centers, automated RNA extraction using KingFisher Flex robotics, sequencing with Illumina's COVIDSeq NGS workflow including analysis with the Dragen COVIDSeq analysis pipeline, and reporting. The final report includes COVID-19 strain identification, genome sequencing coverage, confirmed mutations, consensus genome, and raw sequence files. Zymo uses its DNA/RNA Shield preservative to inactivate the SARS-CoV-2 virus and stabilize its RNA.

Feb 09, 2021

Tempus xG

Tempus has launched a new germline sequencing assay, xG, a 52-gene panel that specifically identifies genetic variants associated with hereditary cancer syndromes and inherited risk of cancer. The test is performed by BioReference Laboratories' subsidiary GeneDx and joins Tempus' existing suite of oncology-focused testing offerings, including tumor and liquid biopsy tests, HRD, and TO (tumor of unknown origin) assays.

Feb 03, 2021

Swift Biosciences Normalase Amplicon SARS-CoV-2 S Gene Panel

Swift Biosciences has released the Normalase Amplicon SARS-CoV-2 S Gene Panel (SNAP), a targeted gene panel that covers 100 percent of the SARS-CoV-2 S gene even with limited viral titers. The new panel eliminates the need to perform qPCR for library normalization for downstream sequencing, Swift said.

Politico reports that the NYPD DNA database has grown since it announced it would be removing profiles from it.

Forbes reports that a structural biology lab at Oxford University studying the coronavirus was hacked.

Science reports that a Dutch research funding agency is combating a ransomware attack.

In Science this week: set of 64 haplotype assemblies from 32 individuals, and more.