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Qiagen QiaSeq Direct SARS-CoV-2 Kit

Qiagen has launched the QiaSeq Direct SARS-CoV-2 Kit, a viral genome enrichment and library preparation product that the company said significantly reduces library turnaround times and plastics use compared with ARTIC project protocols (primer-based approaches for next-generation sequencing that are considered the gold standard for SARS-CoV-2 genome sequencing). QiaSeq Direct SARS-CoV-2 supports sample multiplexing with up to 768 Dual Molecular Indices, unique markets tagged to molecules in a sample to eliminate downstream analysis errors. Starting from extracted viral RNA, the library prep workflow can be as little as four hours, Qiagen said. In addition, plastics usage can be reduced by as much as 50 percent. Qiagen said the new kit is supported by Qiagen's Digital Insights CoV-2 Insights Service, a cloud-based solution tailored to viral genome analysis, characterization, and reporting.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.