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Promega LMR MSI Analysis System

Promega has launched its LMR MSI Analysis system, a PCR-based research tool with novel markers for detecting microsatellite instability. The panel consists of eight total markers: four gold-standard markers (BAT-25, BAT-26, MONO-27, and NR-21) and four novel long mononucleotide repeat markers (BAT-52, BAT-56, BAT-59, and BAT-60). According to the company combining these marker sets expands MSI detection ability in difficult samples while maintaining overlap with data gathered using traditional markers. Promega said that the assay has been optimized to enable strong and balanced amplification even from degraded samples such as formalin-fixed, paraffin-embedded tissue.

The Scan

Suicidal Ideation-Linked Loci Identified Using Million Veteran Program Data

Researchers in PLOS Genetics identify risk variants within and across ancestry groups with a genome-wide association study involving veterans with or without a history of suicidal ideation.

Algorithm Teases Out Genetic Ancestry in Individuals at Biobank Scale

Researchers develop an algorithm known as Rye to tease apart ancestry fractions in admixed individuals at a biobank-scale, applying it to 488,221 UK Biobank participants in Nucleic Acids Research.

Multi-Ancestry Analysis Highlights Comparable Common Variants at Complex Trait-Linked Loci

Researchers in Nature Genetics examine common variants implicated in more than three dozen conditions, estimating genetic effect similarities across ancestry tracts in admixed individuals.

Sick Newborns Selected for WGS With Automated Pipeline

Researchers successfully prioritized infants with potential Mendelian conditions for whole-genome sequencing or rapid whole-genome sequencing, as they report in Genome Medicine.