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Philip Morris International GladiaTox

Philip Morris International (PMI) has launched GladiaTox, an open-source informatics product for high-content screening data in biomedical research. According to PMI, GladiaTox allows "robust and efficient storage, processing, and reporting of HCS data, in line with the landmark 21st Century Toxicology program." The firm's platform is an evolution of the ToxCast Pipeline created for the US Environmental Protection Agency. The solution can analyze disparate types of HCS data in an integrated fashion and supports the "3S" approach to biological understanding – "systematic, systemic, and systems," which looks at organisms in their entirety rather than specific organs in isolation. PMI developed GladiaTox in collaboration with Filer Consulting.

The Scan

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.

Study Looks at Parent Uncertainties After Children's Severe Combined Immunodeficiency Diagnoses

A qualitative study in EJHG looks at personal, practical, scientific, and existential uncertainties in parents as their children go through SCID diagnoses, treatment, and post-treatment stages.

Antimicrobial Resistance Study Highlights Key Protein Domains

By screening diverse versions of an outer membrane porin protein in Vibrio cholerae, researchers in PLOS Genetics flagged protein domain regions influencing antimicrobial resistance.

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.