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Personalis Neoantigen Discovery Report

Personalis has launched the Neoantigen Discovery Report for the company's ACE ImmunoID service. The report predicts peptides which can be generated from each expressed somatic variant and then characterizes those by predicting MHC Class I and II binding affinities based on the patient's HLA alleles, and to both self and known antigens. It combines best-in-class and proprietary tools to aide in the rapid evaluation and prioritization of samples and peptides based on a client's needs, the company said.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.