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Personalis ACE ImmunoID NGS Services

Personalis has launched an expansion of its services to immune-oncology research and clinical trials with its Accuracy and Content Enhanced ImmunoID product. This product addresses shortcomings in typical NGS cancer offerings, such as sequence biases and gaps in gene coverage, and features leading-edge informatics pipelines supporting both RNA and DNA analysis as well as tumor-normal analysis to aid in the detection of neoantigens, Personalis said. ACE fills in NGS sequencing gaps through Personalis' enhanced targeted enrichment which optimizes sample prep and targeted capture in difficult-to-sequence regions, such as regions of high-GC content. The ACE cancer exome and ACE cancer panel augment over 1,600 cancer and immune-oncology genes as well as key non-coding regions. High-coverage ACE sequencing data provides sensitive detection of small variants and CNVs at low allele frequencies. In addition, RNA data from the same sample, targeted to the same gene set, is used to quantify gene expression — critical for immune-oncology applications — in addition to detecting gene fusions and confirming allelic expression. 

The Scan

Hormone-Based Gene Therapy to Sterilize Domestic Cat

A new paper in Nature Communication suggests that gene therapy could be a safer alternative to spaying domestic cats.

Active Lifestyle Linked to Type 2 Diabetes Prevention in People at High Genetic Risk

A study in the British Journal of Sports Medicine shows that an active lifestyle goes a long way in type 2 diabetes prevention.

Beneficial, Harmful Effects of Introgression Between Wild and Domesticated European Grapes

A paper in PNAS shows that European wild grapevines were an important resource for improving the flavor of cultivated wine grapes.

Genetic Ancestry of South America's Indigenous Mapuche Traced

Researchers in Current Biology analyzed genome-wide data from more than five dozen Mapuche individuals to better understand their genetic history.