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PerkinElmer NEXTflex Unique Dual Index Barcodes

PerkinElmer has added NEXTflex unique dual index barcodes to its NEXTflex family of library prep products. These 192 barcoded adapters provide data security in sequencing applications for use on Illumina platforms. This system is designed to mitigate index hopping and signal spreading, a phenomenon associated with multiplexing. Instruments utilizing a patterned flow cell and exclusion amplification technology experience increased levels of sample misassignment as a result. These adapters address the important issue of sample misidentification, thereby enabling assurance of data integrity, the company said. By allowing researchers to pool multiple libraries in a single flow cell lane, multiplexing with the NEXTflex barcoded adapters also increases processing capacity, while reducing costs.

The Scan

Wolf Howl Responses Offer Look at Vocal Behavior-Related Selection in Dogs

In dozens of domestic dogs listening to wolf vocalizations, researchers in Communication Biology see responses varying with age, sex, reproductive status, and a breed's evolutionary distance from wolves.

Facial Imaging-Based Genetic Diagnoses Appears to Get Boost With Three-Dimensional Approach

With data for more than 1,900 individuals affected by a range of genetic conditions, researchers compared facial phenotype-based diagnoses informed by 2D or 3D images in the European Journal of Human Genetics.

Survey Suggests Multigene Cancer Panel VUS Reporting May Vary Across Genetic Counselors

Investigators surveyed dozens of genetic counselors working in clinical or laboratory settings, uncovering attitudes around VUS reporting after multigene cancer panel testing in the Journal of Genetic Counseling.

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.