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Paragon Genomics CleanPlex Target Enrichment Solution

Paragon Genomics has launched its CleanPlex target enrichment solution. The product uses the company's patented amplicon sequencing technology which effectively removes nonspecific PCR products generated during highly multiplexed PCR reactions. This 10-minute digestion step is crucial in achieving high-quality libraries before targeted sequencing, the company said. It removes DNA fragmentation, hybridization, and ligation processes associated with traditional hybrid capture-based methods.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.