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Pacific Biosciences Sequel Chemistry and Software Update

Pacific Biosciences has launched a new chemistry, V2, and new software, V4, for its Sequel sequencing system that will be available on Jan. 23. The release also includes a new version of the consumable SMRT cells. The updates improve the system's ability to support applications such as structural variant detection and targeted sequencing for tasks such as metagenomics, minor variant detection, and isoform sequencing. The mean read length is now 10 to 18 kilobases, with half the data in reads larger than 20 kilobases. Throughput is now 5 to 8 gigabases, depending on sample type and sample prep method used. The system is now also capable of loading 80-kilobase sequencing libraries. The new software includes updates to the base-calling algorithm that increase accuracy and new features to the system software to support clinical research applications.

The Scan

Study Reveals New Details About Genetics of Major Cause of Female Infertility

Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.

Circulating Tumor DNA Shows Potential as Biomarker in Rare Childhood Cancer

A study in the Journal of Clinical Oncology has found that circulating tumor DNA levels in rhabdomyosarcoma may serve as a biomarker for prognosis.

Study Recommends Cancer Screening for Dogs Beginning Age Seven, Depending on Breed

PetDx researchers report in PLOS One that annual cancer screening for dogs should begin by age seven.

White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds

A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans.