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Oxford Nanopore PromethIon 24, PromethIon 48

Oxford Nanopore Technologies said this week that its PromethIon 24 and PromethIon 48 sequencing platforms are now available for users to order. The instruments can run up to either 24 or 48 flow cells, respectively, and include a computer for real-time data analysis. The run time ranges from 1 minutes to 64 hours, and the best yield per run with 1D reads so far has been 7.6 terabytes, based on customer data, with a theoretical maximum of 15 Tb. There is no instrument cost, but users must pay for a $20,000 annual service contract. Flow cells range in price from $625 to $2,000, depending on order type and volume, and reagent costs per run are $99.

The Scan

Harvard Team Report One-Time Base Editing Treatment for Motor Neuron Disease in Mice

A base-editing approach restored SMN levels and improved motor function in a mouse model of spinal muscular atrophy, a new Science paper reports.

International Team Examines History of North American Horses

Genetic and other analyses presented in Science find that horses spread to the northern Rockies and Great Plains by the first half of the 17th century.

New Study Examines Genetic Dominance Within UK Biobank

Researchers analyze instances of genetic dominance within UK Biobank data, as they report in Science.

Cell Signaling Pathway Identified as Metastasis Suppressor

A new study in Nature homes in on the STING pathway as a suppressor of metastasis in a mouse model of lung cancer.