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New England Biolabs NEBNext Ultra II RNA Library Prep Kits

New England Biolabs has launched an expansion of its NEBNext Ultra II NGS library preparation portfolio with the NEBNext Ultra II Directional RNA Library Prep kit and the non-directional NEBNext Ultra II RNA Library Prep kit. Both kits are designed for Illumina's next generation sequencing systems and are compatible with poly(A) mRNA isolation and ribosomal RNA depletion. Libraries can be constructed from a substantially broader input range (5 ng to 1 µg of total RNA) at high yields. They also use workflows that include new reagents, combined steps, and minimized cleanup steps.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.