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New England Biolabs NEBNext Ultra II FS DNA Library Prep Kit

New England Biolabs has launched the NEBNext Ultra II FS Library Prep Kit for enzyme-based DNA fragmentation and library preparation for next-generation sequencing. The kit combines fragmentation, end repair, and dA-tailing in a single tube. Input DNA amounts can range from 100 picograms to 0.5 micrograms and library preparation can be completed in 2.5 hours, with less than 15 minutes of hands-on time. The kit is also available with SPRISelect beads for size selection and cleanup steps.

The Scan

Breast Cancer Risk Related to Pathogenic BRCA1 Mutation May Be Modified by Repeats

Several variable number tandem repeats appear to impact breast cancer risk and age at diagnosis in almost 350 individuals carrying a risky Ashkenazi Jewish BRCA1 founder mutation.

Study Explores Animated Digital Message Approach to Communicate Genetic Test Results to Family Members

In the Journal of Genetic Counseling, the approach showed promise in participants presented with a hypothetical scenario related to a familial hereditary breast and ovarian cancer syndrome diagnosis.

Computational Tool Predicts Mammalian Messenger RNA Degradation Rates

A tool called Saluki, trained with mouse and human messenger RNA data, appears to improve mRNA half-life predictions by taking RNA and genetic features into account, a Genome Biology paper reports.

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.