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New England Biolabs NEBNext Direct Genotyping Solution

New England Biolabs has launched the NEBNext Direct Genotyping Solution, a capture-based approach for high-throughput genotyping in ag-bio applications. The new kit, for use with next-generation sequencing, uses highly multiplexed, capture-based enrichment to deliver automatable genotyping in a single day. The product can be used with 100 to 5,000 markers, features pre-capture multiplexing of up to 96 samples, and allows for more than 3.8 million genotypes in a single Illumina sequencing run.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.