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New England Biolabs NEBNext Direct Genotyping Solution

New England Biolabs has launched the NEBNext Direct Genotyping Solution, a capture-based approach for high-throughput genotyping in ag-bio applications. The new kit, for use with next-generation sequencing, uses highly multiplexed, capture-based enrichment to deliver automatable genotyping in a single day. The product can be used with 100 to 5,000 markers, features pre-capture multiplexing of up to 96 samples, and allows for more than 3.8 million genotypes in a single Illumina sequencing run.

The Scan

Breast Cancer Risk Related to Pathogenic BRCA1 Mutation May Be Modified by Repeats

Several variable number tandem repeats appear to impact breast cancer risk and age at diagnosis in almost 350 individuals carrying a risky Ashkenazi Jewish BRCA1 founder mutation.

Study Explores Animated Digital Message Approach to Communicate Genetic Test Results to Family Members

In the Journal of Genetic Counseling, the approach showed promise in participants presented with a hypothetical scenario related to a familial hereditary breast and ovarian cancer syndrome diagnosis.

Computational Tool Predicts Mammalian Messenger RNA Degradation Rates

A tool called Saluki, trained with mouse and human messenger RNA data, appears to improve mRNA half-life predictions by taking RNA and genetic features into account, a Genome Biology paper reports.

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.