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New England BioLabs NEBNext Direct Custom Ready Panels

New England Biolabs has launched the NEBNext Direct Custom Ready Panels, which allow users to design customized panels from a library of pre-synthesized baits for about 850 genes associated with a number of human diseases. The panels use the NEBNext Direct target enrichment technology, which hybridizes genomic DNA with biotinylated probes and converts the captured molecules into sequence-ready libraries. A unique molecular identifier tag is added to each DNA molecule prior to the final PCR amplification step. New England Biolabs said it will periodically update the panels to add new genes to the list and will update content corresponding to changes in gene definition and coordinates.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.