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New England Biolabs' NEBNext Direct Cancer HotSpot Panel

New England Biolabs, or NEB, has launched the NEBNext Direct Cancer HotSpot Panel. The new panel incorporates a novel targeted enrichment technology for next-generation sequencing, NEBNext Direct, that was developed in collaboration with Directed Genomics, the company said. The new technology leverages NEB's deep expertise in enzymology to maximize yields and minimize errors that can be introduced during sample preparation. The Cancer HotSpot panel combines the strength of both PCR amplicon and hybridization based approaches to employ a single tube, single day workflow that combines enrichment with library preparation. It enriches critical regions within 50 commonly studied genes known to be associated with cancer.

The Scan

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.

Seagull Microbiome Altered by Microplastic Exposure

The overall diversity and the composition at gut microbiome sites appear to coincide with microplastic exposure and ingestion in two wild bird species, according to a new Nature Ecology and Evolution study.

Study Traces Bladder Cancer Risk Contributors in Organ Transplant Recipients

In eLife, genome and transcriptome sequencing reveal mutation signatures, recurrent somatic mutations, and risky virus sequences in bladder cancers occurring in transplant recipients.

Genes Linked to White-Tailed Jackrabbits' Winter Coat Color Change

Climate change, the researchers noted in Science, may lead to camouflage mismatch and increase predation of white-tailed jackrabbits.