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New England Biolabs: Monarch HMW DNA Extraction Kits

New England Biolabs has released two high molecular weight (HMW) DNA extraction kits. Both the Monarch HMW DNA Extraction Kit for Cells & Blood and the Monarch HMW DNA Extraction Kit for Tissue utilize a novel glass bead-based technology that allows for more efficient and cost-effective extraction. They can extract DNA up to several megabases in size from cells, blood, tissue, or bacteria, with workflows that range from 30 minutes to 90 minutes in duration. The extracted DNA can be used in downstream applications such as long-read sequencing, optical mapping, and linked-read genome assembly. The new kits complement the company's Monarch Genomics DNA Purification Kit and can be used alongside its NEBNext Companion Module for Oxford Nanopore Technologies Ligation Sequencing kit.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.