NanoString nCounter Vantage Assays

Apr 14, 2016

Nanostring Technologies has launched its nCounter Vantage assay portfolio to power 3D biology experiments in cancer research. The portfolio includes two new RNA panels for the detection of fusion genes in lung cancer and leukemia samples, two new protein panels covering solid tumor biology and immune-cell signaling, and one new DNA panel for the detection of single nucleotide variations. The assays allow for multiplexed, digital analysis of DNA, RNA and protein simultaneously in a single experiment, the company said.

The new assays will be featured at the American Association for Cancer Research's annual meeting taking place in New Orleans, April 17-20.

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Sep 18, 2018

Roche Navify Clinical Trial Match, Navify Publication Search

Roche has launched two Navify clinical decision support apps, called Navify Clinical Trial Match and Navify Publication Search, to help oncologists access clinical trial information and publications. Both are available on the Navify Tumor Board platform.

The Navify Clinical Trial Match app identifies clinical trial options from 11 international registries, based on patient-specific attributes such as age, sex, biomarkers, and various tumor attributes. The registries include ClinicalTrials.gov, the German Clinical Trials Registry (DRKS), and the European Clinical Trials Registry (EUCTR).

The Navify Publication Search app mines several publication sources, including PubMed, the American Society of Clinical Oncology, and the American Association of Central Cancer Registries, for relevant literature. The content of both apps is provided by MolecularMatch, a clinical informatics company.

Roche plans to add more apps, including from partners and third parties, in the future.

Sep 18, 2018

Amsbio circulating tumor DNA reference standards

Amsbio has launched a new range of circulating tumor DNA reference standards: a set of highly characterized, quantitative multiplex quality controls to support the development of new assays. The standards are engineered to mimic the fragmentation profile of nucleosomal ctDNA (aproximately 166 bp) observed in real patient samples across a range of allele frequencies. Pre-validated by digital PCR, the kits include cancer-associated mutations in EGFR, PIK3CA, NRAS and KRAS, and are available as purified DNA or in a synthetica plasma.
 

Sep 13, 2018

Viracor Eurofins CMV Resistance:Letermovir

Viracor Eurofins has launched CMV Resistance:Letermovir, a cytomegalovirus gene sequencing assay for the detection of resistance to Prevymis (letermovir), an antiviral for use in adult hematopoietic stem cell transplant patients. The assay is available as a standalone test or as a complete panel with the other CMV drugs as CMV Resistance: Letermovir, Ganciclovir, Foscarnet, Cidofovir. Viracor Eurofins said that resistance to Prevymis has not been detected in treatment-naive patients, but noted that clinical trials have shown that resistance can develop in the UL56 gene after exposure for some HSCT patients. 

Sep 13, 2018

ABclonal Technology DNA, RNA Library Prep

ABclonal Technology has launched next-generation sequencing library prep kits for DNA and RNA sequencing, including its Rapid DNA Lib Prep Kit, StepWise DNA kit, and both stranded and non-stranded mRNA library prep kits. The kits are compatible with Illumina sequencing technology and have a 70 percent DNA conversion efficiency with 500 picograms of input, the company said. They range in price from $218 to $558.

Sep 12, 2018

Fluidic Analytics Fluidity One

Fluidic Analytics has announced the launch of its Fluidity One system, which offers researchers the ability to observe protein behavior by measuring the size and concentrations in their native state without the need for surfaces or matrices. Based on the firm's fluidic separation and detection technology, the system analyses protein in solution and in their natural state using microfluidic diffusional sizing. The tool uses as little as 50 nanograms and produces results in less than 10 minutes. 

Sep 11, 2018

Empirical Bioscience EB Pure Plasmid Mini-Prep Kit

Empirical Bioscience has launched its new EB Pure Plasmid Mini-Prep Kit, which combines the firm's High-Bind technology with alkaline-SDS lysis of bacterial cells. The kit's High-Bind technology reversibly binds DNA or RNA under optimized conditions, removing proteins and other contaminants. It requires one to five milliliters of bacterial culture and delivers results in less than 30 minutes. It also isolates high-quality plasma or cosmid DNA for extraction up to 10 kilobases and yields up to 20 micrograms per preparation, the firm said.

The kit features an integrated pH indicator within the lysis buffer, which changes color to bright yellow when the lysis buffer reaches the pH level needed for DNA binding. The kit also includes a neutralization buffer, Rnase A, activation buffer, washing buffer, elution buffer, spin columns, and collection tubes. The components create a flexible kit for downstream applications, including automated fluorescent DNA sequencing and restriction enzyme digestion, Empirical added.

Sep 07, 2018

Asuragen QuantideX NGS Data Hotspot 21 RUO Kit

Asuragen announced the CE marking and launch of its QuantideX NGS DNA Hotspot 21 Kit, a targeted next-generation sequencing panel to detect variants across a multitude of tumor types. By screening for the most commonly observed variants in a simplified workflow, the research-use-only kit addresses current clinical and laboratory challenges regarding NGS testing such as long time-to-result, high assay complexiity, and lengthy data interpretation.

The assay includes the firm's cGMP manufactured, end-to-end NGS-in-a-box design, providing the reagents needed to prepare sequencing-ready libraries in as little as 24 hours. The firm's bioinformatics software examines whether enough amplifiable DNA exists. 

Sep 04, 2018

Genoptix BCR-ABL MRDx TFR Monitoring Test

Genoptix has released its BCR-ABL MRDx TFR Monitoring Test for patients with chronic myeloid leukemia being treated with Tasigna. According to the firm, the assay is the only diagnostic  test authorized by the US Food and Drug Administration for managing patients on tyrosine kinase inhibitors. 

Aug 29, 2018

Xifin LIS 5

Xifin has launched the latest version of its lab information system, the Xifin LIS 5. The software-as-a-service-based platform includes multi-specialty workflows for molecular and next-generation sequencing. It also includes universal image management, a digital pathology consultation function, and a feature to facilitate multidisciplinary care team coordination.

Updates to the system's existing NGS module provide more specimen management, user-defined workflow steps, and the ability to support multiple lab processes. The platform's enhanced clinical trials support system now provides a project-oriented workflow. An enhanced anatomic pathology module improves the speed and functionality of new specialty workflows for gynecologic cytology, urology, and GI applications. The molecular diagnostic and genomics workflows now support FISH, gene microarray, and PCR, as well as NGS pharmacogenomics testing.

Aug 28, 2018

Empirical Bioscience EB Pure PCR Purification Kit

Empirical Bioscience has launched the EB Pure PCR Purification Kit to streamline DNA purification and recover high-quality DNA in 10 minutes. The kit uses silica-based technology, binding DNA in high-salt and eluting it in a low-salt buffer without requiring organic extractions or additional precipitation steps. The kit includes binding buffer, activation buffer, elution buffer, washing buffer, spin columns, and collection tubes. In addition, the firm said it provides maximum recovery of DNA bands from 100bp to 10kb that are free of oligonucleotides, nucleotides, and polymerase, with yields exceeding 80 percent from DNA amounts of up to 20 µg.

Aug 28, 2018

Swift Biosciences Amplicon HS Panels

Swift Biosciences has announced the early-access availability of its Swift Amplicon HS Panels, a high-sensitivity targeted amplicon library preparation kit for next-generation sequencing of liquid biopsy samples, including cell-free DNA. According to the firm, the panels allow detection and validation of mutations occurring at 0.25 percent to 3 percent frequency among a background of host samples.

The first kit being made available is Swift's EGFR Pathway Panel, which covers clinically relevant oncology hotspots including EGFR T790, KRAS G12/G13, NRAS Q61, and BRAF V600. The firm is also building custom panels and aims to release a Sample_ID panel for fetal/maternal tracing with the same sensitivity and specificity capability.

Aug 24, 2018

Cell Microsystems AIR System

Cell Microsystems has announced the commercial launch of its automated AIR System for imaging, sorting, and isolating of single cells and small colonies. The tool is based on the firm's CellRaft technology, which allows researchers to culture single cells in an array of thousands of microwells contained in the CytoSort Array consumable. After imaging each cell using the system's three-channel fluorescent and brightfield capabilities, researchers can choose cells for later isolation and downstream molecular analysis, the firm said. 

Aug 23, 2018

NuGen mRNA-Seq Library Preparation Kit

NuGen Technologies, acquired by Tecan earlier this month, has launched new mRNA-seq library preparation kits integrated with the NuQuant library quantification method. The library quantification method allows researchers to directly measure NGS library molar concentration, or the number of sequenceable molecules in seconds. Researchers can quantify NGS libraries using NuQuant's method on standard fluorometers. 

Aug 22, 2018

Sema4 NIPT and Expanded Carrier Screening Tests

Sema4 has launched a noninvasive prenatal test and an expanded carrier screening test, which it developed using its Sema4 Health Intelligence Platform. The NIPT is available in three options: a standard panel that tests for trisomies 21, 18, and 13; a standard plus panel that also includes trisomies 15, 16, and 22, as well as sex chromosome aneuploidies; and an expanded panel that includes all of the above plus some microdeletions.

The expanded carrier screen can test more than 280 genes, including 101 genes associated with Jewish founder mutations. Patients also have the option of analyzing a smaller subset of genes.

Aug 22, 2018

Seq2Know Familial Hypercholesterolemia Testing

Seq2Know has begun offering familial hypercholesterolemia testing. Its test includes the sequencing of four genes — LDLR, APOB, PCSK9, and LDLRAP1 — that cause FH. Like all of Seq2Know's tests, the FH test is ordered directly from the company and reviewed by PWNHealth, an independent physician network, for patient appropriateness. Genetic counseling is also available through PWNHealth. Seq2Know is a testing service of PreventionGenetics, a DNA testing lab offering genetic sequencing services.

The UK's Human Fertility and Embryology Authority calls for consumer genetic testing companies to warn customers that testing could uncover family secrets, according to the Guardian.

The New York Times reports that United Nations delegates have been discussing how to govern the genetic resources of the deep sea.

Researchers have transplanted edited cells into mice that appear to combat cocaine addiction, New Scientist reports.

In PNAS this week: analysis of proteolytic enzymes secreted by circulating tumor cells, phylogenetic study of Fv1 evolution, and more.

Sep
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Sponsored by
St. Jude Children's Research Hospital

This webinar will provide an overview of how St. Jude Cloud, a public repository of pediatric cancer genomics data and analysis tools, is impacting cancer research.

Oct
02
Sponsored by
Roche

In the last few years several molecular testing methodologies — such as immunohistochemistry, PCR, and sequencing — have been approved by the US Food and Drug Administration to aid in the management of patients with lung cancer.  

Oct
04
Sponsored by
Agilent

This webinar will discuss the use of new software tools to support the diagnosis of CTFR-related disorders using next-generation sequencing.

Oct
10
Sponsored by
Philips Genomics

This webinar will provide a first-hand look at how the Dana-Farber Cancer Center is adapting its oncology care strategy in light of the rapidly evolving molecular landscape.