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Meridian Bioscience Inhibitor Tolerant 1-Step RT-qPCR Mix

Meridian Bioscience launched its Inhibitor Tolerant 1-step RT-qPCR Mix, an enzyme master mix that eliminates the need for an RNA extraction kit before running a sample through a molecular assay. Meridian developed the master mix formulation because it said RNA isolation and purification is time consuming and expensive. The company also noted that RNA extraction kits have been in short supply during the COVID-19 pandemic. 

When combined with SARS-CoV-2 primers and probes, the proprietary master mix can be used by laboratories to eliminate RNA purification, reducing processing times by as much as 30 minutes and lowering test costs.  

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.