Meridian Bioscience Inhibitor-Resistant qPCR Chemistries

Meridian Bioscience launched two novel inhibitor-resistant qPCR chemistries for the detection of DNA and RNA molecules directly from liquid biopsy samples without needing nucleic acid extraction. The mixes can be used to develop cancer diagnostic tests and workflows requiring fast turnaround times while ensuring high specificity. 

The mixes can tolerate high levels of inhibitors in blood, allowing for improvements in limit of detection by adding more sample in the reaction, Meridian said. Studies have shown superior sensitivity compared to other mixes, even in samples with difficult conditions, such as 20 percent blood, the company added. 

Establishing molecular tests to detect circulating cancer biomarkers can be difficult due to sample variability and inhibitory properties of the specimen, issues Meridian says its two new mixes can help fix.